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Compounds affecting glycemic index

A technology of blood sugar index and compounds, applied in the field of flavonoids and flavonoid derivatives, can solve problems such as increased symptoms

Inactive Publication Date: 2012-05-16
SACRON INNOVATIONS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Postprandial hyperglycemia is thought to be a major risk factor associated with diabetes, but is now thought to also contribute to an increased risk of atherosclerosis and other conditions in non-diabetic populations

Method used

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  • Compounds affecting glycemic index
  • Compounds affecting glycemic index
  • Compounds affecting glycemic index

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Experimental program
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Effect test

Embodiment Construction

[0078] The present invention arose from the discovery of flavonoid derivatives which exhibit surprisingly high levels of potency as inhibitors of alpha-amylase and / or alpha-glucosidase. These compounds are suitable for use as glycemic index lowering agents to provide control of blood sugar levels.

[0079] In a first aspect, although not necessarily the only form, or indeed the broadest form, the invention resides in a compound of formula I as described above, and / or a salt thereof, for use as a glycemic index lowering agent and / or as a As alpha-amylase and / or alpha-glucosidase inhibitors:

[0080]

[0081] Formula I

[0082] in,

[0083] R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and R 12 independently selected from hydrogen, alkyl, alkenyl, arylalkyl, hydroxyalkyl, hydroxyl, aldehyde, alkanone, carboxyl, carboxamide, alkanoyl, alkoxycarbonyl, aryloxycarbonyl, carbonate, O- Alkyl, O-aryl, O-alkenyl, O-alkanoyl, O-alkenoyl or sugar units;

[...

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Abstract

Compounds of formula I are disclosed which are useful as glycemic index lowering agents and / or, as a-amylase and / or a-glucosidase inhibitors. Also disclosed are nutritional and / or pharmaceutical compositions and supplements comprising one or more of these compounds. The compounds will be beneficial to patients who require stabilization of their postprandial glucose levels.

Description

field of invention [0001] The present invention relates to compounds useful for modulating the glycemic index of carbohydrate-containing foods. More specifically, the present invention relates to flavonoids and flavonoid derivatives isolated from sugar cane for use as glycemic index lowering agents. Background of the invention [0002] The glycemic index (GI) is a measure of the effect of dietary carbohydrates on blood sugar levels. Carbohydrates that break down rapidly during digestion release glucose quickly into the bloodstream and thus have a high GI, whereas carbohydrates that break down slowly release glucose into the bloodstream gradually and have a low GI. [0003] To determine the GI value of a food, a measured proportion of food containing 10-50 grams of carbohydrates was administered to 10 healthy individuals who had fasted overnight. Finger blood samples were taken at 15-30 minute intervals over the next two hours. Glycemic response curves over a two-hour peri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30A61K36/899A61P3/04A61P3/10A61K31/352C07D311/40
CPCC07D311/30A61K31/352A61P3/04A61P3/06A61P43/00A61P3/10A61K36/899
Inventor 迪奥纳·纳丁·佩恩大卫·诺曼·利奇蜜尔娜·A·蒂斯欧卡罗尔·安·莫里斯
Owner SACRON INNOVATIONS