Gip receptor-active glucagon compounds

A peptide and composition technology, applied in the field of glucagon peptide analogs, can solve troublesome and dangerous problems
CN102459325BInactive Publication Date: 2015-03-25INDIANA UNIV RES & TECH CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INDIANA UNIV RES & TECH CORP
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

Glucagon peptides with increased GIP activity are provided, optionally with GLP-I and / or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid sequence substantially similar to native glucagon are provided herein.
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Description

technical field

[0001] The present invention provides a glucagon peptide analog that exhibits agonist activity on the gastric inhibin receptor (GIP). Methods of using the analogs are also presented herein. Background technique

[0002] Pre-proglucagon is a 158-amino acid precursor polypeptide that is processed in different tissues to form many different proglucagon-derived peptides, including: pancreas Glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and tomodulin (OXM; oxyntomodulin), which participate in various physiological functions, including Glucose homeostasis, insulin secretion, gastric emptying, and intestinal growth, and regulation of food intake. Glucagon (Glucagon) is a peptide containing 29 amino acids, which is composed of amino acids 33 to 61 corresponding to the preproglucagon, and glucagon-like peptide-1 (GLP-1) is produced as the corresponding It is a 37-amino acid peptide consisting of amino acids 72 to 108 in the preproglucag...

Claims

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