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Preparation method for molecular imprinting film

A technology of molecularly imprinted membrane and preparation steps, which is applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc.

Inactive Publication Date: 2012-06-13
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The current commercial membranes such as ultrafiltration, microfiltration and reverse osmosis membranes cannot achieve the selective separation of individual substances. Molecularly imprinted membranes are an emerging technology that combines the advantages of molecular imprinting technology and membrane separation technology. One of the research hotspots in the field of imprinting technology, molecularly imprinted membranes provide an effective way for specific target molecules to be separated from mixtures of their structural analogs

Method used

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  • Preparation method for molecular imprinting film

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Example 1 Preparation of L-tryptophan molecularly imprinted membrane

[0022] Take the following technical measures in turn:

[0023] A. Before use, the nylon membrane is soaked in an aqueous solution of N,N,N',N'-tetramethylethylenediamine with a volume ratio of 10:1 for 40 minutes, and then taken out and placed in a vacuum oven at 35°C for 2 hours to dry.

[0024] B. Dissolve 0.1mmol of L-tryptophan in 20mL of acetone. After the template molecule is completely dissolved, add 0.4mmol of polymerized monomer acrylamide, and place it at 4°C for 6 hours, so that the template molecule can fully interact with the functional monomer. Then add 2mmol of cross-linking agent ethylene glycol dimethacrylate, ultrasonic degassing for 5min, and then high-purity nitrogen for 5min, after adding 15mg of initiator azobisisobutyronitrile, place the nylon membrane in the above reaction mixture solution , take it out after soaking for 1min, put it between two pieces of glass, squeeze it ha...

Embodiment 2

[0025] Embodiment 2 The preparation of sulfamethoxazole molecularly imprinted membrane

[0026] Take the following technical measures in turn:

[0027] A. The nylon membrane is soaked in an aqueous solution of N,N,N',N'-tetramethylethylenediamine with a volume ratio of 5:1 for 60 minutes before use, and then taken out and placed in a vacuum oven at 30°C for 6 hours to dry.

[0028] B. Dissolve 0.4mmol of template molecule sulfamethoxazole in 20mL of acetone. After the template is completely dissolved, add 1.6mmol of functional monomer acrylamide and place it at 4°C for 12 hours to allow the template molecule to fully interact with the functional monomer. Then 8 mmol of crosslinker ethylene glycol dimethacrylate was added. Ultrasonic degassing for 5 minutes, and then argon for 10 minutes, immediately put the nylon membrane in the above reaction mixture solution, soak for 1 minute and take it out. Place it between two pieces of clean and dry glass, squeeze it hard to remove ai...

Embodiment 3

[0029] Example 3 Preparation of Adrenaline Molecularly Imprinted Membrane

[0030] Take the following technical measures in turn:

[0031] A. The nylon membrane is soaked in an aqueous solution of N,N,N',N'-tetramethylethylenediamine with a volume ratio of 8:1 for 30 minutes before use, and then taken out and placed in a vacuum oven at 40°C for 6 hours to dry.

[0032] B. Dissolve 0.4mmol of the template molecule adrenaline in 20mL of glacial acetic acid. After the template is completely dissolved, add 1.6mmol of the functional monomer acrylamide and place it at 4°C for 8 hours to allow the template to fully interact with the functional monomer. Then 8 mmol of crosslinker ethylene glycol dimethacrylate was added. Ultrasonic degassing for 5 minutes, and then high-purity nitrogen for 5 minutes, immediately put the nylon membrane in the above reaction mixture solution, soak for 1 minute and take it out. Place it between two pieces of glass, squeeze it hard to remove air bubbles...

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Abstract

The invention discloses a preparation method for a molecular imprinting film, and specifically relates to an in situ polymerization method on a thin film substrate. According to the preparation method, acrylamide or acrylic acid and the like is adopted as a polymeric monomer, ethylene glycol dimethacrylate or methylene bisacrylamide and the like is adopted as a cross-linking agent, an in situ polymerization treatment is performed on the thin film substrate in presence of template molecules, the template molecules are removed to obtain the target molecular imprinting film. The prepared molecular imprinting film of the present invention has advantages of high selectivity, large adsorption capacity, good stability, and the like, can be used for chemiluminescence sensors, and has good application potential.

Description

technical field [0001] The invention relates to a preparation method of a molecular imprinted membrane, which belongs to the field of molecular imprinted technology. Background technique [0002] Molecular imprinting technology is an experimental preparation technology for obtaining polymers that completely match specific molecules (usually called template molecules) in terms of spatial structure and binding sites. more and more widely. The current commercial membranes such as ultrafiltration, microfiltration and reverse osmosis membranes cannot achieve the selective separation of individual substances. Molecularly imprinted membranes are an emerging technology that combines the advantages of molecular imprinting technology and membrane separation technology. One of the hotspots in the field of imprinting technology, molecularly imprinted membranes provide an effective way to separate specific target molecules from the mixture of their structural analogs. The preparation o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/10B01D67/00G01N21/76
Inventor 罗川南邱化敏孙敏
Owner UNIV OF JINAN
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