Preparation method of artificial bone scaffold with controllable porosity
A technology of artificial bone and porosity, which is applied in the direction of bone implants, etc., can solve the problems that it is difficult to meet the bone needs of different parts of patients with individual differences, and cannot control the porosity, so as to achieve accurate, effective and controllable porosity and reduce contamination. Chance, controlling the effect of postprocessing time
Active Publication Date: 2015-09-23
西安博恩生物科技有限公司
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Problems solved by technology
[0007] In order to overcome the shortcomings of the prior art artificial bone scaffolds that cannot control the porosity, it is difficult to meet the individual differences of patients and the needs of different parts of the bone
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[0021] Specific implementation examples
[0022] In this embodiment, the preparation method of bioceramic microsphere artificial bone scaffold with controllable porosity specifically includes the following steps: a preparation method of bioceramic microsphere artificial bone scaffold with controllable porosity specifically includes the following steps:
[0023] Step 1. Use PFC3D particle flow software for modeling and simulation. Take the diameter D of the large ball as 0.6mm and the diameter d of the small ball as 0.3mm. When the porosity of the artificial bone is 0.59, the ratio N of the number of large and small balls is 1 : 6.
[0024] Step 2, the computer processes the three-dimensional CAD model of the artificial bone scaffold, and sequentially divides it into five two-dimensional cross-sectional graphics with a spacing of 0.6mm from bottom to top, wherein the size of 0.6mm is the diameter of the bioceramic microsphere;
[0025] Step 3. Import the five two-dimensional c...
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The invention discloses a preparation method of an artificial bone support with controllable porosity, which comprises the following steps of: establishing a CAD (Computer-Aided Design) model according to the individual characteristics of patients; introducing the model into a three-dimensional printer; analyzing a particle flow software number value computing result according to a disperse number value; and mixing biological ceramic small balls and biological instantly-dissolved small balls according to a certain proportion; and spraying biological adhesive through the three-dimensional printer to adhere the mixed balls so as to prepare the artificial bone support. In order to overcome the defect that in the prior art, during the preparation process, sintering can cause pollution, in the invention, the porosity is obtained by instantly dissolving the instantly-dissolved small balls into the biological dissolved solution, so that the pollution of the sintering and chemical reaction during the preparation process on the artificial bone support can be avoided, and in addition, by controlling the number and the radius of the instantly-dissolved small balls, the biological ceramic artificial bone support with a certain mechanical property and porosity can be obtained.
Description
[0001] Field: [0002] The invention relates to a method for preparing an artificial bone scaffold based on porous bioceramic microspheres. It involves using discrete numerical simulation and particle flow numerical simulation as calculation theories to obtain active bioceramic microsphere artificial bone scaffolds with different porosity by controlling the number and radius of instant biospheres. Background technique: [0003] Human bones have a certain ability to regenerate and self-repair, but for large bone defects caused by trauma, infection, tumors and developmental deformities, relying solely on the self-repair function of bone organs cannot heal, and bone transplantation is required. The transplant materials mainly include autologous bone, allogeneic bone and artificial bone replacement. The effect of autologous bone tissue transplantation is very good, and there is no immune rejection reaction, but the source is limited, secondary surgery is required, and there are of...
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IPC IPC(8): A61F2/28
Inventor 汪焰恩魏庆华秦琰磊李鹏林杨明明潘飞龙郭叶叶东东龙水军毛海龙韩琴王月波周金华魏生民
Owner 西安博恩生物科技有限公司