Preparation method of surface-grafted type anion chromatographic filling material
An anion chromatography and surface grafting technology, applied in anion exchange, chromatographic anion exchanger, ion exchange, etc., can solve the problems of small capacity of anion chromatography column, uneven filler ball diameter, complicated preparation process, etc., and achieve low cost , Narrow particle size distribution, good chemical stability
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Embodiment 1
[0025] Embodiment 1: the making process of surface grafted polystyrene-divinylbenzene filler is as follows, and its steps are:
[0026] 1. Synthesize monodisperse polystyrene seeds with a particle size of 1 to 3 μm by emulsion dispersion polymerization, the concentration of monomeric styrene is 5 to 30% (m / m) of the total amount, and the amount of stabilizer polyvinylpyrrolidone is the reaction medium 0.5-4% (m / v), the amount of initiator azobisisobutyronitrile is 1-5% (m / m) of the amount of monomer, the reaction medium is aqueous ethanol, and the concentration is 75-100% (v / v), the reaction temperature is 40-85°C, the stirring speed is 100-400 rpm, and the reaction time is 8-24 hours;
[0027]2. Then prepare monodisperse polystyrene-divinylbenzene microspheres with a crosslinking degree of 10-75% by a seed swelling method. The concentration of monomer styrene is 10-20% (m / m) of the total organic phase, and the range of cross-linking degree of the composite microspheres is 1...
Embodiment 2
[0031] Embodiment 2: with reference to the method and steps of embodiment 1
[0032] 1. Synthesize monodisperse polystyrene seeds with a particle size of 1.6 μm by emulsion dispersion polymerization, the concentration of monomeric styrene is 25% (m / m) of the total amount, and the amount of stabilizer polyvinylpyrrolidone is 1.6% of the reaction medium (m / v), initiator azobisisobutyronitrile consumption is 2.2% (m / m) of monomer consumption, reaction medium is 90% ethanol aqueous solution, 80 ℃ of reaction temperature, stirring speed, at 300 rev / mins, reaction Time 24 hours;
[0033] 2. Then prepare monodisperse polystyrene-divinylbenzene microspheres with a crosslinking degree of 50% by seed swelling method. Monomer styrene concentration is 14% (m / m), emulsifier sodium lauryl sulfate consumption is 2.5% (m / m), stabilizer polyvinyl alcohol consumption is 1.5% (m / m), initiator over The amount of benzoyl oxide is 0.8% (m / m), the amount of porogen toluene is 50% (m / m), the swelli...
Embodiment 3
[0038] 1. Synthesize monodisperse polystyrene seeds with a particle size of 1.6 μm by emulsion dispersion polymerization, the concentration of monomeric styrene is 25% (m / m) of the total amount, and the amount of stabilizer polyvinylpyrrolidone is 1.6% of the reaction medium (m / v), initiator azobisisobutyronitrile consumption is 2.2% (m / m) of monomer consumption, reaction medium is 90% ethanol aqueous solution, 80 ℃ of reaction temperature, stirring speed, at 300 rev / mins, reaction Time 24 hours;
[0039] 2. Then prepare monodisperse polystyrene-divinylbenzene microspheres with a degree of crosslinking of 50% by the seed swelling method, the monomer styrene concentration is 14% (m / m), and the emulsifier lauryl sulfate Sodium consumption is 2.5% (m / m), stabilizer polyvinyl alcohol consumption is 1.5% (m / m), initiator benzoyl peroxide consumption is 0.8% (m / m), porogen toluene consumption is 50% % (m / m), the swelling ratio is 55 times, the emulsification temperature is 20°C, th...
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