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Multiple sensitive hydrogel material and preparation method thereof

A multi-sensitive, hydrogel technology, applied in the field of polymer chemistry, can solve the problems of unsatisfactory, few reports of reversible hydrogel systems, and single factor

Inactive Publication Date: 2012-06-27
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, one of the main shortcomings of sol-gel reversible physical hydrogels is that the corresponding factors are relatively single, such as reversible hydrogel systems that are sensitive to oxidants and electricity, and there are relatively few reports.
(T. Ohkubo, et al. J Am Chem Soc2004, 126, 12282-12283; Y. Takeoka, et al. Adv Mater 2007, 19, 2807-2812; Y.J. Zhang, et al. Macromolecules 2011, 44, 2245-2252 .) Especially in medical applications, it is often required that the gel system can respond to various changes in the body and release drugs, but most of the current multi-response sol-gel reversible hydrogels only have dual functions of pH and temperature. Responsiveness, unable to meet the needs of practical applications

Method used

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  • Multiple sensitive hydrogel material and preparation method thereof
  • Multiple sensitive hydrogel material and preparation method thereof
  • Multiple sensitive hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 30 mg of carboxymethyl konjac glucomannan grafted β-cyclodextrin (CKGM-g-β-CD, grafting rate 15.6%) to prepare a 3% solution, add a corresponding amount of polyether P65 two The molecular product of ferrocenecarboxylic acid (P65-Fc, conversion rate 82.3%) was terminated so that its concentration was 22%. The mixture of CKGM-g-β-CD and P65-Fc (β-CD:Fc=1:1) was stirred and dispersed at room temperature for 12 hours to obtain a multi-sensitive hydrogel system. This system can undergo a reversible transition of sol-gel-sol (sol-gel-sol) with temperature change. Among them, it is in the gel state between 22-85°C. In addition, when the system is in the state of gel, 0.1 mL of sodium hypochlorite is added, and it can be found that the system responds to this stimulus after 5 hours and changes to the state of sol.

Embodiment 2

[0024] Weigh 20mg of polyacrylic acid-polymethacrylic acid copolymer grafted β-cyclodextrin (PAA-co-PMAA-g-β-CD, grafting rate 13.6%) to prepare 8% solution, add corresponding amount The ferrocenecarboxylic acid molecular product (P65-Fc, with a conversion rate of 73.5%) was connected to both ends of the polyether P65, so that the concentration was 16%. Mix PAA-co-PMAA-g-β-CD and F610-Fc (β-CD:Fc=2:1) ​​and stir and disperse at 10°C for 24 hours to obtain a multi-sensitive hydrogel system. This system can undergo a reversible transition of sol-gel-sol (sol-gel-sol) with temperature change. Among them, it is in the gel state between 25-73°C. In addition, when the system is in the state of gel, 0.05 mL of hydrogen peroxide is added, and it can be found that the system changes to the state of sol in response to this stimulus after 3 hours. If PAA-co-PMAA-g-β-CD / F65-Fc in the gel state is inserted into the electrode and a direct current of 6.0v is applied, the system can be obse...

Embodiment 3

[0026] Weigh 50 mg of sodium alginate grafted β-cyclodextrin (Alg-g-β-CD, grafting rate 20.1%) to prepare a 5% solution, add a corresponding amount of polyether F127 terminally connected ferrocene The acetic acid molecular product (F127-Fc, conversion 50.5%) was made to a concentration of 20%. Mix Alg-g-β-CD and F127-Fc solution, and 10mg / mL glucose oxidase GOD (β-CD:Fc=1:3), stir and disperse at 4°C for 24h, then multiple sensitive Hydrogel system. This system can undergo a reversible transition of sol-gel-sol (sol-gel-sol) with temperature change. Among them, it is in the gel state between 20-95°C. Add 0.05mL peroxide ((NH 4 )Ce(NO 3 ) 6 ), it can be found that the system changes to the sol state in response to this stimulus after 10 h. In addition, when the system was in gel state, 0.1 mL of saturated glucose solution was added, and it was found that the system transformed into sol state in response to this stimulus after 3 days.

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Abstract

The invention belongs to the technical field of high-molecular chemistry and relates to a multiple sensitive hydrogel material and a preparation method thereof. The hydrogel material comprises a polymer with cyclodextrin (subject) and polyether pluronic modified by ferrocene (object) group. A gel formation method comprises steps of: simultaneously dissolving the polymer with cyclodextrin and the polyether pluronic with ferrocene group in water; and stirring and dispersing thoroughly under certain solution condition, so as to form a large amount of crosslinking netted organizations based on subject and object identification in the solution. The gel material can response to environment temperature change, oxidizing agent, existence of electric field or change of glucose concentration to generate gel-sol conversion. The invention has advantages of simple preparation method, environment-friendliness and thrift, and has huge application value in biomedicine.

Description

technical field [0001] The invention belongs to the technical field of polymer chemistry, and relates to a multi-sensitive hydrogel material and a preparation method thereof. Background technique [0002] Hydrogel is a multi-component system formed by water and a three-dimensional polymer network. The so-called sensitive hydrogel refers to the ability to respond to external environmental stimuli (such as pH, light, temperature, electricity, etc.) and trigger its own structural properties (such as swelling, shrinkage, or sol-gel (sol-gel) changes) Altered hydrogel systems. This responsiveness to external stimuli makes sensitive hydrogels have broad application prospects in many fields such as molecular devices, separation of active substances, controlled drug release, and bionics. [0003] According to the different types of cross-linking, polymer hydrogels can be divided into chemical cross-linking hydrogels and physical hydrogels. In chemical hydrogels, the three-dimensi...

Claims

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Application Information

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IPC IPC(8): C08L71/00C08L5/04C08L5/02C08L33/02C08L77/02C08L67/04C08L5/08C08J3/24C08J3/075A61K47/40A61K47/34G01N25/00G01N27/00
Inventor 李帮经谭淋张晟哈伟彭树林丁立生
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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