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Chinese actinidia root extract and preparation method thereof

A root extract and extract technology are applied in the field of vine pear root extract and its preparation, can solve the problems of poor adsorption, unsatisfactory flavonoid components of vine pear root, etc., achieve anti-tumor effect, cheap elution and easy operation Effect

Inactive Publication Date: 2012-07-04
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Purification of polyamides shows poor adsorption of flavonoids from vine root
Therefore, the above two methods are not ideal for the purification of flavonoids in vine root, and macroporous resins are widely used in the purification of traditional Chinese medicine extracts, and have been used to purify flavonoids and other traditional Chinese medicine ingredients.

Method used

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  • Chinese actinidia root extract and preparation method thereof
  • Chinese actinidia root extract and preparation method thereof
  • Chinese actinidia root extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: get the decoction pieces of vine pear root, add 10 times the amount of 40% ethanol, reflux extraction, each 1.5h, extract 3 times, filter, merge the filtrate, concentrate, the macroporous resin column on the concentrated solution, first use 3 times column volume of water, and then 3 times column volume of 50% ethanol, the eluate recovered ethanol and concentrated, and dried under reduced pressure to obtain the extract for later use; then the above extract was used containing 10% The 80% ethanol liquid of low-substituted hydroxypropyl cellulose (L-HPC) is used as a binder, and the ratio of dry powder: bifidosaccharide: starch is 10:3:2 and placed in a granulator to stir to make granules, namely have to.

Embodiment 2

[0031] Example 2: Take the decoction pieces of vine pear root, add 8 times the amount of 80% ethanol, reflux extraction, 1 hour each time, extract 3 times, filter, combine the filtrate, concentrate, and put the concentrated solution on the macroporous resin column, first use 1 times The column volume was eluted with water, and then eluted with 70% ethanol of 5 times the column volume, the eluent was concentrated under reduced pressure, and spray-dried to obtain the extract, which was set aside; then the above extract was added to 15% CMS-Na, Use 5% PVP ethanol solution as a binder, and press it into a tablet.

Embodiment 3

[0032]Example 3: Take the decoction pieces of vine pear root, add 12 times the amount of 60% ethanol, reflux extraction, 1 hour each time, extract 3 times, filter, combine the filtrate, concentrate, and put the concentrated solution on the macroporous resin column, first use 2 times The water elution of column volume, then elution with 60% ethanol of 4 times of column volume, eluate is concentrated under reduced pressure, spray-dried to become extract, for subsequent use; The above-mentioned standby material is mixed with maltodextrin, microcrystalline fiber (MCC ), calcium stearate and mix well, put it into the plastic shell, and get it.

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Abstract

The invention relates to a Chinese actinidia root extract and a preparation method thereof. Details of the specific preparation method are shown in the specification. The Chinese actinidia root extract has the advantages that: the general flavone content of the extract is over 50 percent, the extract has a good antitumor effect, and dosage forms such as particles, tablets, hard capsules, soft capsules, dripping pills, oral liquids and the like are prepared according to the conventional process.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to an extract of vine pear root and a preparation method thereof. Background technique [0002] Tengli root contains flavonoids, triterpenoids, phenols, anthraquinones, steroids and sugars and other compounds. Tengli root is also known as round jujube, vine pear and foreign peach vine. It has the functions of strengthening the stomach, clearing away heat and promoting dampness It is commonly used in the treatment of esophageal cancer, gastric cancer, colorectal cancer and breast cancer among the people, and has achieved certain curative effect. And clinically, vine pear root has applications in anti-tumor, anti-inflammation and anti-virus, anti-oxidation and liver protection, immune regulation and other aspects. Many studies believe that these effects of vine root are closely related to its flavonoids. Due to the complex composition of the vine root extract, the preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K125/00
Inventor 白吉庆王小平
Owner SHAANXI UNIV OF CHINESE MEDICINE
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