Compound traditional Chinese medicinal dripping pills for treating hyperosteogeny and preparation method thereof

A technology for bone hyperplasia and compounding, which is applied to pharmaceutical formulas, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Low cost and less side effects

Inactive Publication Date: 2014-01-01
BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above dosage forms have slow dissolution rate and poor absorption, and have their own shortcomings and deficiencies in clinical application.

Method used

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  • Compound traditional Chinese medicinal dripping pills for treating hyperosteogeny and preparation method thereof
  • Compound traditional Chinese medicinal dripping pills for treating hyperosteogeny and preparation method thereof
  • Compound traditional Chinese medicinal dripping pills for treating hyperosteogeny and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) compound extraction:

[0040] Proportion of Chinese medicinal materials: Aconite (made) 14.8g, Aconitum (made) 7.4g, cinnamon 3.7g, Codonopsis 11.1g, Angelica 11.1g, Paeoniae Alba 11.1g, Epimedium 11.1g, frankincense 7.4g Weigh each medicinal material , crushed into 20 mesh powder. Put the traditional Chinese medicine in an extraction tank, add water 9 times the total amount of medicinal materials, heat and boil for 1.5 hours, and filter while it is hot. Repeat the above steps, add 7 times of water to the filter residue, boil for 50min and filter while hot. Continue to repeat the above steps, add 5 times of water to the filter residue, boil for 30min and then filter. Combine the three filtrates, put them in a large-capacity centrifuge, centrifuge at 4000r / min for 30min, and discard the precipitate.

[0041] (2) Alcohol precipitation: the supernatant was precipitated with 80vt% ethanol.

[0042] (3) Purification of extract: the precipitate is adsorbed by macropor...

Embodiment 2

[0046] (1) compound extraction:

[0047]Proportion of Chinese medicinal materials: Aconite (made) 14.8g, Aconitum (made) 7.4g, cinnamon 3.7g, Codonopsis 11.1g, Angelica 11.1g, Paeoniae Alba 11.1g, Epimedium 11.1g, frankincense 7.4g Weigh each medicinal material , crush 20 mesh powder. Put the traditional Chinese medicine in an extraction tank, add water 6 times the total amount of medicinal materials, heat and boil for 1.5 hours, and filter while hot. Repeat the above steps, add 7 times of water to the filter residue, boil for 50 minutes and then filter while hot. Continue to repeat the above steps, add 5 times of water to the filter residue, boil for 30 minutes and then filter. Combine the three filtrates, put them in a large-capacity centrifuge, centrifuge at 3500r / min for 30min, and discard the precipitate.

[0048] (2) Alcohol precipitation: the supernatant was precipitated with 75vt% ethanol.

[0049] (3) Purification of extract: Adsorbed by macroporous adsorption res...

Embodiment 3

[0053] (1) compound extraction:

[0054] Proportion of Chinese medicinal materials: Aconite (made) 14.8g, Aconitum (made) 7.4g, cinnamon 3.7g, Codonopsis 11.1g, Angelica 11.1g, Paeoniae Alba 11.1g, Epimedium 11.1g, frankincense 7.4g Weigh each medicinal material , crush 20 mesh powder. Put the traditional Chinese medicine in an extraction tank, add water 10 times the total amount of medicinal materials, heat and boil for 1.5 hours, and filter while it is hot. Repeat the above steps, add 10 times of water to the filter residue, boil for 1 hour, and then filter while hot. Continue to repeat the above steps, add 6 times of water to the filter residue, boil for 30 minutes and then filter. Combine the three filtrates, put them in a large-capacity centrifuge, centrifuge at 4600r / min for 30min, and discard the precipitate.

[0055] (2) Alcohol precipitation: the supernatant was precipitated with 80vt% ethanol.

[0056] (3) Purification of extract: Adsorbed by macroporous adsorpti...

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Abstract

The invention relates to compound traditional Chinese medicinal dripping pills for treating hyperosteogeny, which are prepared by the following steps: proportionally weighing medicinal materials Radix Aconite (processed), aconite roots (processed), Chinese cinnamon, Radix codonopsitis, Angelica sinensis, white peony roots (parched), Herba Epimedii and olibanum (processed), extracting with water for three times, merging supernatants, centrifuging, precipitating with alcohol, and purifying with macroporous adsorption resin to obtain an extract; mixing the extract with a matrix which is a mixture of PEG (polyethylene glycol) 4000 and PEG6000, and dripping with dimethyl silicon oil as a coolant under a certain dripping temperature, dripping aperture, dripping speed and dripping distance to obtain the compound dripping pills. The invention also discloses a preparation method of the compound dripping pills. The traditional Chinese medicinal dripping pills for treating hyperosteogeny, disclosed by the invention, have simple and feasible preparation method and no contamination; and the prepared dripping pills are convenient for administration, have good safety, low adverse side effects and low cost, and are suitable for large-scale production. The dripping pills of the invention have the effects of warming yang, dispelling cold, supplementing qi, activating blood circulation and relieving swelling and pain, and can be used for treating hypertrophic arthritis in cervical vertebrae and knee joints due to insufficiency of yang and cold dampness.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and specifically relates to a Chinese medicine compound dripping pill for treating hyperosteogeny and a preparation method thereof. Background technique [0002] The traditional Chinese medicine compound for the treatment of bone hyperplasia (the original prescription with Guigutong compound) consists of 13-16 parts of aconite (made), 5-8 parts of Chuanwu (made), 2-4 parts of cinnamon, 9-11 parts of Codonopsis pilosula, 9-10 parts of angelica. 12 parts, white peony root (stir-fried) 9-11 parts, epimedium 9-11 parts, and frankincense (made) 5-8 parts are composed of 8 traditional Chinese medicines. In the treatment of yang-deficiency cold-dampness type neck cone and knee joint hypertrophic arthritis, the clinical effective rate is over 90%. play a major role in hypertrophic arthritis. The currently clinically used dosage forms are mainly: Fuguigutong Granules, Fuguigutong Cap...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61P19/08A61K47/34A61K36/714A61K9/20
Inventor葛喜珍赵双龙林强田平芳孟婷婷
OwnerBIOCHEM ENG COLLEGE OF BEIJING UNION UNIV