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Metal ion decoration meso pore silicon oxide and preparation method thereof

A technology of mesoporous silica and metal ions, applied in the field of biomedical materials, can solve the problems of small drug loading capacity and lack of biological activity of mesoporous silica, and achieve the effect of enhancing deposition ability

Inactive Publication Date: 2012-07-11
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to solve the problems of lack of biological activity and small drug loading capacity of mesoporous silica, and propose a metal ion-modified mesoporous silica and its preparation method

Method used

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  • Metal ion decoration meso pore silicon oxide and preparation method thereof
  • Metal ion decoration meso pore silicon oxide and preparation method thereof
  • Metal ion decoration meso pore silicon oxide and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 0.5595g of Ca(NO 3 ) 2 4H 2 O was added to 10 mL of deionized water, and after it was completely dissolved, 0.7 g of mesoporous silica was added. After fully dispersed, the solvent was evaporated at 25 °C to obtain a white solid, which was dried at 80 °C to constant weight. The dried white solid was heated to 550°C at a heating rate of 1°C / min in an air atmosphere, and calcined at 550°C for 2 hours to obtain calcium ion-modified mesoporous silica with a calcium / silicon molar ratio of 0.02.

Embodiment 2

[0023] 0.2442g of Zn(NO 3 ) 2 ·6H 2 O was added to 20 mL of demethanol, and after it was completely dissolved, 0.7 g of mesoporous silica was added. After fully dispersed, the solvent was evaporated at 30°C to obtain a white solid, which was dried at 50°C to constant weight. The dried white solid was heated up to 600°C at a heating rate of 5°C / min in an air atmosphere, and calcined at 600°C for 5 hours to obtain zinc ion-modified mesoporous silica with a zinc / silicon molar ratio of 0.07.

Embodiment 3

[0025] 0.7623g of Mg(NO 3 ) 2 ·6H 2 O was added to 20 mL of deionized water, and after it was completely dissolved, 2.0 g of mesoporous silica was added. After fully dispersed, the solvent was evaporated at 25°C to obtain a white solid, which was dried at 50°C to constant weight. The dried white solid was heated to 700° C. at a heating rate of 10° C. / min in an air atmosphere, and calcined at 700° C. for 3 hours to obtain magnesium ion-modified mesoporous silica with a magnesium-silicon molar ratio of 0.09.

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Abstract

The invention discloses metal ion decoration meso pore silicon oxide with biological functions and a preparation method thereof. A high bioactivity meso pore silicon oxide material is obtained, and the bioactivity, surface structure, medicine load ratio and the like can be adjusted by adjusting content and type of metal ions. The metal ion decoration meso pore silicon oxide resolves the problem that a meso pore silicon oxide material has no bioactivity, and can improve the load ratio of medicine in a meso pore and widen application in the field of orthopedics.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to metal ion-modified mesoporous silica applied to orthopedic repair materials and drug carriers and a preparation method thereof. Background technique [0002] In recent years, with the increase of patients with bone defects, especially osteoporosis and osteomyelitis and other orthopedic diseases, a large amount of bone repair materials are required for bone implant surgery. Currently commercialized orthopedic repair materials such as metal and calcium phosphate have many problems during the implantation process, such as slow repair rate and complications. For this reason, when implanting bone repair materials, it is necessary to load biological growth factors and slow-release drugs to promote tissue healing and enhance the therapeutic effect. Drugs for bone repair are different from general drug therapy. On the one hand, the loaded drugs need to promote bone repair o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61K47/02A61K47/04
Inventor 李延报徐虹相昊天陆春华李东旭许仲梓
Owner NANJING TECH UNIV