Method for synthesizing multi-hydroxy flavone compound under assistance of microwaves

Abstract

The invention discloses a preparation method of multi-hydroxy flavone shown as a formula. R can be hydrogen, hydroxyl and the like. Multi-hydroxy flavone has the pharmacological actions of virus resistance, bacterium resistance, tumor resistance, oxidation resistance, cardiovascular and cerebrovascular disease resistance and the like, and the synthesis of the multi-hydroxy flavone has a great practical value. The method comprises the following steps of: reacting 3,4-dimethoxy-5-substituted benzoyl chloride and 2-hydroxyl-4-methoxyacetophenone serving as raw materials to obtain a substituted benzoic acid aryl ester compound; rearranging to obtain a 1,3-disubstituted propanedione compound; generating a 7,3',4'-trimethoxy-5'-substituted flavone compound under the actions of a catalyst and microwaves; and hydrolyzing to obtain a 7,3',4'-trihydroxy-5'-substituted flavone compound. The method has the advantages of simple process, short reaction time, high yield, high product purity, large-scale production and wide application prospect.

Description

technical field The invention discloses a method for synthesizing polyhydroxy flavonoids assisted by microwaves, which belongs to the technical field of organic synthesis. Background technique Flavonoids are an important class of natural organic compounds, which have a good scavenging effect on superoxide anion free radicals and hydroxyl free radicals related to most diseases of the human body, so they have antiviral, antibacterial, antitumor, antioxidative, Wide range of pharmacological effects such as anti-cardiovascular and cerebrovascular diseases. Although natural flavonoids exist in nature in large quantities, due to complex structure, poor solubility, many action sites, low content, and difficulty in extraction, separation and purification, these factors have greatly limited their wide application. Therefore, it is currently a widely used method to prepare new flavonoids with high efficiency and low toxicity through semi-synthetic and total-synthetic methods or carry...

AI Technical Summary

Problems solved by technology

Although natural flavonoids exist in nature in large quantities, due to their complex structure, poor solubility, many action sites, low content, and difficulties in extraction, separation and purification, these factors have greatly limited their wide application.