Preparation method for folic acid

A technology of folic acid and sodium metabisulfite, applied in organic chemistry and other directions, can solve the problems of increasing labor intensity of workers, production costs, large dosage, and complicated operations, and achieve the effects of enhancing market competitiveness, reducing dosage and reducing production costs.

Inactive Publication Date: 2012-07-11
JIHENG PHARMA HENGSHUI CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium acetate is used to adjust the pH value and keep the reaction at a pH value of about 3.0. The operation is more complicated, and sodium ac...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Weigh each raw material according to the following weight:

[0017] N-para-aminobenzoyl glutamic acid: 26Kg

[0018] Sodium metabisulfite: 13Kg

[0019] 6-Hydroxy-2,4,5-triaminopyrimidine sulfate: 39Kg

[0020] Trichloroacetone 26Kg;

[0021] (2) Carry out cyclization reaction to obtain folic acid crude product:

[0022] After adding about 3000L of water into the reaction kettle, start stirring, the stirring speed is about 75-80 rpm, put in the prepared N-p-aminobenzoyl glutamic acid and sodium metabisulfite, open the steam valve, and make the material temperature Keep at 38-45°C, stir for 25-35 minutes, put in 6-hydroxy-2,4,5-triaminopyrimidine sulfate, stir for another 15-20 minutes, half open the valve of the trichloroacetone high level tank, drop Trichloroacetone with a total chlorine content of 8% should be dripped in about half an hour; react for 6 hours after dripping trichloroacetone, and adjust the pH with 10% sodium hydroxide solution to keep it at 3.0...

Embodiment 2

[0024] (1) Weigh each raw material according to the following weight:

[0025] N-para-aminobenzoyl glutamic acid: 26Kg

[0026] Sodium metabisulfite: 26Kg

[0027] 6-Hydroxy-2,4,5-triaminopyrimidine sulfate: 34Kg

[0028] Trichloroacetone 39Kg;

[0029] (2) Carry out cyclization reaction to obtain folic acid crude product:

[0030] After adding about 3500L of water into the reaction kettle, start stirring, the stirring speed is about 75-80 rpm, put in the prepared N-p-aminobenzoyl glutamic acid and sodium metabisulfite, open the steam valve, and make the material temperature Keep at 25-38°C, stir for 25-35 minutes, put in 6-hydroxy-2,4,5-triaminopyrimidine sulfate, stir for another 15-20 minutes, half open the valve of the trichloroacetone high level tank, drop Trichloroacetone with a total chlorine content of 9% should be dripped in about half an hour; react for 4 hours after dripping trichloroacetone, and adjust the pH with 8% sodium hydroxide solution to keep it at 3.5-...

Embodiment 3

[0032] (1) Weigh each raw material according to the following weight:

[0033] N-para-aminobenzoyl glutamic acid: 26Kg

[0034] Sodium metabisulfite: 21Kg

[0035] 6-Hydroxy-2,4,5-triaminopyrimidine sulfate: 26Kg

[0036] Trichloroacetone 52Kg;

[0037] (2) Carry out cyclization reaction to obtain folic acid crude product:

[0038] After adding about 4000L of water into the reaction kettle, start stirring, the stirring speed is about 75-80 rpm, put in the prepared N-p-aminobenzoyl glutamic acid and sodium metabisulfite, open the steam valve, and make the material temperature Keep at 45-55°C, stir for 25-35 minutes, put in 6-hydroxy-2,4,5-triaminopyrimidine sulfate, stir for another 15-20 minutes, half open the valve of the trichloroacetone high level tank, drop Trichloroacetone with a total chlorine content of 10% should be dripped in about half an hour; react for 9 hours after dripping trichloroacetone, and adjust the pH with 5% sodium hydroxide solution to keep it at 2.0...

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PUM

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Abstract

The present invention relates to a preparation method for folic acid. The method comprises the following process steps: (1) weighing various raw materials according to a weight part ratio; (2) adopting a liquid alkali to adjust the pH value of the raw materials at the temperature of 25-55 DEG C to maintain the pH value of 2.0-5.0, and carrying out a cyclization reaction for 4-9 hours to obtain the folic acid crude product. With the method of the present invention, the folic acid production cost is reduced; the price of the liquid alkali (the sodium hydroxide aqueous solution) is significantly less than the price of sodium acetate, and the use amount is reduced, such that the production cost is substantially reduced, and the market competition ability of the folic acid is enhanced; the sodium acetate is the solid, and can be used before dissolving in the water and adjusting the pH value, and the liquid alkali is the liquid, such that the dissolution operation is eliminated, and the labor intensity of the worker is reduced.

Description

technical field [0001] The invention relates to a preparation method of folic acid. Background technique [0002] In the existing folic acid preparation method, sodium acetate is used to adjust the pH value. After reaching the required value, the crude folic acid is obtained by cooling and pressure filtration, and then the finished product of folic acid is obtained through acid dissolution, water analysis, refining, decolorization, re-refining, centrifugation, and drying. . Because this reaction process produces hydrochloric acid, the acidity is too strong, and the reaction cannot be carried out under too strong acidic environment. Sodium acetate is used to adjust the pH value and keep the reaction at about pH 3.0. The operation is more complicated, and sodium acetate is a strong base and weak salt, and the dosage is relatively large, which virtually increases the labor intensity and production cost of workers. Contents of the invention [0003] The technical problem to ...

Claims

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Application Information

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IPC IPC(8): C07D475/04
Inventor 蔡颂公马朝华刘晓莲马胜义徐亚威辛秀彪
Owner JIHENG PHARMA HENGSHUI CITY
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