Diffuse optical tomography system based on electron multiplication CCD (charge-coupled device) and tomography method

Abstract

The invention belongs to the technical field of physiological parameter measurement, and relates to a diffuse optical tomography system based on an electron multiplication CCD (charge-coupled device), which comprises a steady-state laser source, a translation stage, a coupling lens, a lens, the electron multiplication CCD and a computer. Steady-state laser emitted by the steady-state laser source irradiates a phantom or an object to be measured through incident optical fibers, the translation stage drives an optical fiber head to move so that the laser irradiates various imaging points of the phantom, afterwards, the lens receives transmission light emitted from the phantom to form an image in the electron multiplication CCD, imaging results are transmitted to the computer, and the computer reconstructs the image. The invention further provides a tomography method implemented by using the system. The imaging quality of the reconstructed image can be improved, underdetermined ill-posed nature of imaging algorithm is eliminated at the utmost, and image reconstruction efficiency and precision are improved.

Description

field of invention [0001] The invention belongs to the technical field of physiological parameter measurement, in particular to the application of diffusion optical tomography technology, Background technique [0002] Diffuse Optical Tomography (DOT) technology uses near-infrared light to irradiate the tissue body, detects the diffuse light emitted through the tissue body, and obtains the distribution image of the optical parameters of the human tissue, and infers the tissue density from these optical parameters. Physiological conditions and lesion information, and then realize the diagnosis of diseases. Diffusion optical tomography has the characteristics of non-invasive, safe, non-ionizing radiation and high specificity, and is useful in the early diagnosis of breast tumors. [1-3] , functional brain imaging [4，5] and small animal imaging [6，7] It has great potential for practical application. [0003] However, compared with other mature imaging methods (such as CT, MRI...

AI Technical Summary

Problems solved by technology

[0005] Although various research groups at home and abroad are committed to improving the imaging quality and computational efficiency of DOT, the main problem of DOT technology is still the lack of spatial resolution due to the high scattering of near-infrared light by the tissue.

Moreover, there are more and more clinical requirements for dynamic imaging, how to quickly and effectively process a large amount of measurement data, there is no particularly ideal method at present

For the non-contact measurement method, the influence of the diffusion angle of light propagating in space on the reconstruction is not involved

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