Detection integrated chip and detection method

An integrated chip and detection method technology, applied in the field of analysis and detection, can solve the problems of long detection cycle, complicated operation, expensive price, etc., and achieve the effect of short detection cycle, small size and simple operation

Active Publication Date: 2012-07-18
TIANJIN MNCHIP TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing automatic biochemical analyzer is bulky, expensive, complicated to operate, and needs to be equipped with professional equipment for sample pretreatment, so it needs to be installed in the central laboratory of a large hospital and operated by trained professionals
In addition, in order to improve the detection efficiency and re

Method used

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  • Detection integrated chip and detection method
  • Detection integrated chip and detection method
  • Detection integrated chip and detection method

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0056] Example 1: Blood biochemical analysis

[0057] Such as figure 1 , 2 As shown in and 3, the detection integrated chip of the present invention is made by using transparent plastic as a raw material by injection molding. This chip includes upper layer 4, middle layer 5 and lower layer 6, in which:

[0058] The lower surface of the upper layer 4 is provided with a flow channel 41 connecting the transition groove and the reaction detection groove.

[0059] The middle layer 5 is provided with through holes 51, 52 and the other two groups of through holes 53, 54. The through hole 51 is used to add samples, the through hole 52 is used to add diluent, and the two sets of through holes 53 and 54 respectively react with the lower layer. The detection slot 64 corresponds to the transition slot 618.

[0060] The lower layer 6 is provided with a sample tank 61, a diluent tank 62, a liquid storage tank 63, a reaction detection tank 64, a self-check tank 65, an overflow tank 66, a diluent qu...

Example Embodiment

[0073] Example 2: Water quality testing

[0074] Using transparent plastic as raw material, the chip is made by mold injection, and the first reagent tank 6191 and the second reagent tank 6192 (required by the dual reagent method) are pre-installed for detecting organics (such as phenol) and heavy metal ions (such as Lead, copper, iron), pesticide residues (such as organophosphorus) reagents. Take 1 ml of water sample and add it to the sample tank 61. If dilution is needed, the dilution liquid is injected into the dilution tank 62. Fix the chip on the motor and start the motor to start rotating. The steps of sample transportation, separation, and reaction detection are similar to those in the first embodiment.

Example Embodiment

[0075] Example 3: Food hygiene inspection

[0076] Using transparent plastic as raw material, the chip is made by mold injection, and is pre-installed in the first reagent tank 6191 and the second reagent tank 6192 (required for the dual-reagent method) for detecting microorganisms (such as E. coli) and additives ( Such as saccharification enzyme preparations), pesticide residues (such as organic phosphorus, carbamate pesticides), pollutants (such as inorganic arsenic, formaldehyde, cyanide, nitrite), protein and other reagents. For liquid samples, samples can be directly added to the chip. The solid sample needs to be crushed, then liquid is added to dissolve, and then added to the chip. In particular, various extraction techniques can be used to extract the substance to be tested from the food and then add it to the chip for detection. The detection method is the same as in Example 1.

[0077] Of course, the liquid reaction reagent sealed by the film can also be mechanically p...

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Abstract

The invention discloses a detection integrated chip and a detection method. The chip is divided into an upper layer, a middle layer and a lower layer, wherein the upper layer of the chip is connected with the middle layer of the chip, the middle layer of the chip is connected with the lower layer of the chip; the upper layer or middle layer of the chip is provided with a group of through holes used for loading samples; the lower layer of the chip is provided with a group of grooves; and each layer of the chip is provided with micro-channels used for connecting the grooves. By adopting the chip, the pretreatment, quantitative delivery and reaction of the sample solution can be automatically completed once and the contents of the components of the solution can be detected, thus the detection of the multi-index single-reagent method can be satisfied and the chip can be used in the detection of the multi-index two-reagent method and the multi-reagent method. The chip disclosed by the invention can be used in the analysis and detection fields such as biological analysis, medical detection, environmental pollutant detection, and food and drug safety.

Description

technical field [0001] The invention belongs to the field of analysis and detection, and in particular relates to a detection integrated chip and a detection method integrating sample pretreatment, quantitative delivery, reaction and detection. Background technique [0002] Facing many challenges in the fields of biomedical analysis, disease diagnosis, environmental monitoring, food and drug safety, etc. in the 21st century, the requirements for on-site sampling analysis, rapid detection, and patient self-testing have put forward more requirements for inspection and quarantine analysis methods and equipment. high demands. To meet these new demands, it is necessary to develop miniaturized, integrated and portable inspection and quarantine equipment. [0003] The origin of automated analysis equipment currently used in inspection and quarantine can be traced back to the 1950s. After half a century of development, integration and automation have been realized. For example, th...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N35/00
Inventor 王战会陈坦
Owner TIANJIN MNCHIP TECH CO LTD
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