Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Detection integrated chip and detection method

An integrated chip and detection method technology, applied in the field of analysis and detection, can solve the problems of long detection cycle, complicated operation, expensive price, etc., and achieve the effect of short detection cycle, small size and simple operation

Active Publication Date: 2012-07-18
TIANJIN MNCHIP TECH CO LTD +1
View PDF3 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing automatic biochemical analyzer is bulky, expensive, complicated to operate, and needs to be equipped with professional equipment for sample pretreatment, so it needs to be installed in the central laboratory of a large hospital and operated by trained professionals
In addition, in order to improve the detection efficiency and reduce the detection cost, it is often necessary to collect a large number of samples for unified analysis and detection, so the detection cycle is longer
The characteristics of large-scale automated biochemical analyzers currently used in hospitals are difficult to meet the needs of on-site sampling analysis, rapid detection, and patient self-testing.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Detection integrated chip and detection method
  • Detection integrated chip and detection method
  • Detection integrated chip and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Blood Biochemical Analysis

[0057] Such as figure 1 , 2 As shown in and 3, the detection integrated chip of the present invention is made of transparent plastic as a raw material by injection molding. The chip includes an upper layer 4, a middle layer 5 and a lower layer 6, wherein:

[0058] The lower surface of the upper layer 4 is provided with a flow channel 41 connecting the transition tank and the reaction detection tank.

[0059] The middle layer 5 is provided with through holes 51, 52 and another two groups of through holes 53, 54. The through hole 51 is used to add the sample, the through hole 52 is used to add the diluent, and the two groups of through holes 53 and 54 are respectively connected with the reaction on the lower layer. The detection groove 64 corresponds to the transition groove 618 .

[0060] The lower layer 6 is provided with a sample tank 61, a diluent tank 62, a liquid storage tank 63, a reaction detection tank 64, a self-test t...

Embodiment 2

[0073] Embodiment two: water quality detection

[0074] Using transparent plastic as raw material, the chip is made by injection molding, and pre-installed in the first reagent tank 6191 and the second reagent tank 6192 (needed by the double reagent method) for detecting organic matter (such as phenol) and heavy metal ions (such as lead, copper, iron), pesticide residues (such as organophosphorus) reagents. Take 1 ml of water sample and add it into the sample tank 61 . If dilution is required, the dilution liquid is injected into the dilution tank 62 . Fix the chip on the motor, start the motor and start to rotate. The steps of sample delivery, separation, and reaction detection are similar to those in Example 1.

Embodiment 3

[0075] Example 3: Food Hygiene Testing

[0076] Using transparent plastic as raw material, the chip is made by mold injection, and pre-installed in the first reagent tank 6191 and the second reagent tank 6192 (needed by the double reagent method) to detect microorganisms (such as E. coli), additives ( Reagents such as glucoamylase preparations), pesticide residues (such as organophosphorus, carbamate pesticides), pollutants (such as inorganic arsenic, formaldehyde, cyanide, nitrite), proteins, etc. Liquid samples can be directly sampled and added to the chip. Solid samples need to be crushed, dissolved in liquid, and added to the chip. In particular, various extraction techniques can be used to extract the substance to be tested from the food, and then added to the chip for detection. The detection method is the same as in Example 1.

[0077] Of course, before the liquid reaction reagent sealed by the film flows out of the reagent tank, small holes can also be punched in th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Depthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a detection integrated chip and a detection method. The chip is divided into an upper layer, a middle layer and a lower layer, wherein the upper layer of the chip is connected with the middle layer of the chip, the middle layer of the chip is connected with the lower layer of the chip; the upper layer or middle layer of the chip is provided with a group of through holes used for loading samples; the lower layer of the chip is provided with a group of grooves; and each layer of the chip is provided with micro-channels used for connecting the grooves. By adopting the chip, the pretreatment, quantitative delivery and reaction of the sample solution can be automatically completed once and the contents of the components of the solution can be detected, thus the detection of the multi-index single-reagent method can be satisfied and the chip can be used in the detection of the multi-index two-reagent method and the multi-reagent method. The chip disclosed by the invention can be used in the analysis and detection fields such as biological analysis, medical detection, environmental pollutant detection, and food and drug safety.

Description

technical field [0001] The invention belongs to the field of analysis and detection, and in particular relates to a detection integrated chip and a detection method integrating sample pretreatment, quantitative delivery, reaction and detection. Background technique [0002] Facing many challenges in the fields of biomedical analysis, disease diagnosis, environmental monitoring, food and drug safety, etc. in the 21st century, the requirements for on-site sampling analysis, rapid detection, and patient self-testing have put forward more requirements for inspection and quarantine analysis methods and equipment. high demands. To meet these new demands, it is necessary to develop miniaturized, integrated and portable inspection and quarantine equipment. [0003] The origin of automated analysis equipment currently used in inspection and quarantine can be traced back to the 1950s. After half a century of development, integration and automation have been realized. For example, th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01L3/00G01N35/00
Inventor 王战会陈坦
Owner TIANJIN MNCHIP TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com