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Method for detecting drug morphine through surface enhanced Raman spectroscopy

A surface-enhanced Raman and spectral detection technology, which is applied in Raman scattering, measuring devices, and material analysis through optical means, can solve the problems of complex operation, slow analysis speed, and low sensitivity, and achieve improved sensitivity and easy operation , the effect of lowering the detection limit

Inactive Publication Date: 2012-07-18
CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW
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Problems solved by technology

[0006] The purpose of the present invention is to propose a method for detecting the drug morphine by surface-enhanced Raman spectroscopy in order to solve the problems of complicated operation, slow analysis speed and low sensitivity in the prior art

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  • Method for detecting drug morphine through surface enhanced Raman spectroscopy
  • Method for detecting drug morphine through surface enhanced Raman spectroscopy
  • Method for detecting drug morphine through surface enhanced Raman spectroscopy

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Embodiment 1

[0026] Ordinary Raman spectrum of pure morphine powder, such as figure 1 shown. It can be seen from the figure that the characteristic Raman peaks of morphine appear in the ranges of 440-465cm-1, 520-540cm-1, 600-650cm-1, 1030-1070cm-1 and 1600-17000cm-1 respectively.

[0027] A method for detecting drug morphine using surface-enhanced Raman spectroscopy of the present invention, the specific steps are as follows:

[0028] Step 1, morphine is dissolved in acetonitrile to form a morphine test sample solution, and the Raman spectrum is as follows figure 2 shown.

[0029] Step 2, prepare gold sol, prepare nano-gold into a solution with ultrapure water, and sonicate for 20 minutes to suspend nano-gold in ultra-pure water to obtain nano-gold sol, and place it for later use;

[0030] Step 3, take the test sample solution obtained in step 1 and the gold sol obtained in step 2 and evenly mix it into a sample to be tested, and leave the sample to be tested for 1 minute for use;

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Abstract

The invention belongs to the technical field of drug detection, and particularly relates to a method for detecting drug morphine through surface enhanced Raman spectroscopy, which particularly includes the following steps: step I, pretreating a to-be-detected sample, so as to form sample solution; step II, preparing gold sol or silver sol; step III, uniformly mixing the test sample solution obtained through the step I and the gold sol obtained through the step II, so as to form the to-be-detected sample that is on standing; step IV, enabling the mixed to-be-detected sample obtained through the step III to be dripped on a slide and naturally evaporated for Raman spectrometry, thereby obtaining the SERS spectrogram of the gold sol and the to-be-detected sample; and step V, comparing the SERS spectrogram of the to-be-detected sample with the standard SERS spectrogram of the morphine, so as to determine whether the sample contains the morphine. The method for detecting drug morphine adopts the gold sol made of nano gold as the enhancing agent, so as to effectively improve the sensitivity of Raman spectroscopy, reduce the detection limit, and can increase the Raman spectrogram of the sample.

Description

technical field [0001] The invention relates to a method for detecting drug morphine by using surface-enhanced Raman spectroscopy, and belongs to the technical field of drug detection. Background technique [0002] Morphine (Morphin, Mo) is a kind of isoquinoline alkaloid extracted from opium. It is the most important and most abundant active ingredient in opium, with an average content of 10%. Morphine is widely used in clinical treatment because of its strong analgesic effect. However, the highly addictive nature of morphine makes long-term smokers have serious dependence on morphine both physically and psychologically, resulting in serious drug addiction. Morphine is mixed with a variety of chemical agents, and after further processing, it becomes more toxic heroin. The abuse of morphine drugs has brought great harm to people's life and property. Therefore, in the work of forensic science, it is of great significance to realize the trace, sensitive, accurate, rapid and...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 郝红霞周红陈新明张中连园园刘晓培常靖常林张保生
Owner CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW
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