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Application of cordyceps militaris link extract to preparation of health-care product or medicament for prompting leucocyte proliferation of breast cancer patient

A technology of extract and grass seeds, applied in the field of fruit body extract of Cordyceps militaris, can solve the problems of insufficient coordinated utilization, undiscovered, single active ingredients, etc., and achieve the effect of promoting leukocyte proliferation function, maintaining a long time and good effect

Inactive Publication Date: 2012-08-01
珠海市先康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active ingredient used in it is single, but the cordycepin, cordycepic acid, polysaccharide, ergosterol, etc. in Cordyceps militaris have not been fully coordinated and utilized
No application or product related to the promotion of white blood cell proliferation by Cordyceps militaris extract in tumor patients has been found in relevant literature records

Method used

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  • Application of cordyceps militaris link extract to preparation of health-care product or medicament for prompting leucocyte proliferation of breast cancer patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] From the wild Cordyceps militaris in Changbai Mountain, Jilin, after strict screening, breeding and rejuvenation, the strains with good anti-bacteria pollution, strong growth ability, short growth cycle and good genetic stability were obtained, and the solid medium was prepared and the fruiting body was 60 days old. Cultivate, harvest and dry to obtain the fruiting body of Cordyceps militaris. The resultant Cordyceps militaris fruiting bodies contain more than 3.80 mg / g of cordycepin, more than 45.00 mg / g of cordycepic acid, more than 5.50% of cordyceps polysaccharide, more than 1.60 mg / g of adenosine, more than 3.10 mg / g of ergosterol and more than 3.10 mg / g of total amino acids Greater than 9.00%, the similarity value of the fingerprints of fruiting bodies of Cordyceps militaris in multiple batches is greater than 0.950.

[0034] 300kg of dried fruiting bodies of Cordyceps militaris were pulverized, passed through a 60-mesh sieve, and extracted with 25 times pure wate...

Embodiment 2

[0039] Example 2 The breeding of the Cordyceps militaris strain and the fruiting body cultivation process are the same as in Example 1. Crush 200kg of dried fruiting body of Cordyceps militaris, pass through a 20-mesh sieve, extract with 15 times (V / W) 85% (V / V) ethanol solution for 2 hours, and then use 10 times (V / W) 85% (V / V) Ethanol solution extraction for 2 hours. The extract was centrifuged and filtered to obtain a clarified extract. The extract was concentrated under reduced pressure and vacuum. After recovering ethanol, the concentration temperature was controlled not to exceed 60°C. The concentrated extract was vacuum-dried under reduced pressure and crushed to obtain 44kg of ethanol extract of Cordyceps militaris.

[0040] According to the conventional capsule filling method, it is prepared into capsules of fruiting bodies of Cordyceps militaris or extract capsules, each 200 mg.

Embodiment 3

[0041] Example 3 Functional experiment of water extract of Cordyceps militaris fruiting body

[0042] The effect of the fruiting body extract of Cordyceps militaris on increasing the number of white blood cells in cancer chemotherapy patients was investigated by crowd clinical trials.

[0043]The experiment adopted a 2×2 crossover design. Using the random number table, 71 breast cancer patients were randomly divided into two groups according to the ratio of 1:1: YN (the fruiting body extract of Cordyceps militaris in Example 1) group and NY (not taking the fruiting body extract of Cordyceps militaris) group . All patients underwent chemotherapy twice after diagnosis of breast cancer. YN group took Cordyceps militaris fruiting body extract capsules at the same time of the first chemotherapy, and did not take it at the second chemotherapy. NY group took Cordyceps militaris fruiting body extract capsules at the same time of the second chemotherapy, and the first chemotherapy D...

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Abstract

The invention discloses an application of a cordyceps militaris link extract to preparation of a health-care product or a medicament for prompting leucocyte proliferation of a breast cancer patient. In an extracting method of the cordyceps militaris link extract, water or an ethanol solution is adopted for extracting cordyceps militaris link. As proved by clinical test of a breast cancer chemotherapy patient, the extract has a good effect on prompting the leucocyte proliferation of the chemotherapy patient, and can be used for preparing a health-care food or a medicament for assisting in treating tumors. The invention discloses a novel clinical application of cordyceps militaris link after increase of leucocytes after chemotherapy on the breast cancer patient. The cordyceps militaris link extract plays a positive role in comprehensively utilizing and developing cordyceps militaris link.

Description

technical field [0001] The invention relates to a new application of the fruiting body extract of Cordyceps militaris. Background technique [0002] Tumors have gradually replaced cardiovascular and cerebrovascular diseases as the number one killer in the world, and the incidence and mortality of tumors have been increasing worldwide in the past two decades. Due to the tendency of malignant tumors to spread and spread, more and more people pay more and more attention to the chemotherapy of tumors. At the same time, the toxic and side effects of chemotherapy have attracted more and more attention from medical staff and patients. [0003] Breast cancer is the main malignant tumor that endangers women's health, accounting for 32% of female malignant tumors. The cause of the disease is that under the action of various internal and external tumorigenic factors, the cells lose their normal characteristics and appear abnormal proliferation, so that the malignant tumor occurs beyon...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61P35/00A61P37/04
Inventor 吴美兰吴更余李秋洋黄杏云钟美婵郑令文姚磊
Owner 珠海市先康生物科技有限公司
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