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Combined filter membrane for efficient filtration of leukocyte, manufacturing method thereof and leukocyte filter

A white blood cell and filter technology, applied in the field of white blood cell filter, can solve the problems of not reaching 3log removal of white blood cells, decrease of positive charge of the copolymer, and reduction of the adsorption force of the filter membrane to white blood cells, etc.

Active Publication Date: 2014-11-05
NANJING RED CROSS BLOOD CENT +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under high-temperature sterilization conditions, the externally coated copolymer will undergo vitrification changes, resulting in a decrease in the positive charge of the copolymer, reducing the adsorption of the filter membrane to leukocytes, and ultimately reducing the filtration rate of the leukocyte filter. Cannot meet the basic requirement of 3log depletion of leukocytes

Method used

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  • Combined filter membrane for efficient filtration of leukocyte, manufacturing method thereof and leukocyte filter
  • Combined filter membrane for efficient filtration of leukocyte, manufacturing method thereof and leukocyte filter
  • Combined filter membrane for efficient filtration of leukocyte, manufacturing method thereof and leukocyte filter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation of combined filter membrane

[0030] Spray the non-alkali ultra-fine glass fiber slurry with a diameter of 0.5-5 μm evenly on the flat polyester fiber non-woven fabric. The spraying amount per square meter of non-woven fabric is 25-30 grams per square meter. The excess glass fiber slurry is covered with a layer of polyester fiber non-woven fabric. The weight of the upper and lower layers of non-woven fabric is 25-30 grams per square meter, and it is rolled and dried with hot rollers to obtain a semi-finished product. The polyester fiber non-woven fabric can be pre-coated with polyethylene or polypropylene hot-melt adhesive before spraying the glass fiber to make the combined filter membrane stick tightly.

[0031] 2. Synthesis of Acrylic Copolymer

[0032] Ethanol is used as a solvent, and butyl acrylate, methyl methacrylate, hydroxyethyl methacrylate, acrylic acid, hydroxyethyl acrylate, and aminoethyl methacrylate are used as comonomers. The initiator...

Embodiment 2

[0040] This example is basically the same as Example 1, except that the concentration of the acrylic copolymer solution is 1 mg / ml.

Embodiment 3

[0042] This embodiment is basically the same as Embodiment 1, except that the concentration of the acrylic copolymer solution is 9 mg / ml.

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Abstract

The invention discloses a combined filter membrane for efficient filtration of leukocyte, a manufacturing method thereof and a leukocyte filter. The combined filter membrane is manufactured by clamping a fiberglass layer between two polyester fiber non-woven cloth layers, and is coated with acrylic acid type copolymer to make combination of two different types of fibers solider, the hydrophilic properties of the combined filter membrane can be maintained after high-temperature steam sterilization, uniform copolymer coated on the fiberglass surface can be molten and contracted to be distributed like a pearl during high-temperature sterilization, the glass body can be exposed, the surface of the glass body contains positive charges, leukocyte contains negative charges, and the capacity of the combined filter membrane to filter leukocyte can be significantly improved due to mutual attraction of the positive charges and the negative charges. The combined filter membrane is used as a fine filter membrane to replace part of polyester non-woven cloth and is taken as a filter medium and arranged in the leukocyte filter, the comprehensive online filtration can be realized, and the rate of leukocyte filtration exceeds 99.99 percent.

Description

technical field [0001] The invention relates to the application field of leukocyte filters, in particular to a combined filter membrane for highly efficient filtering of leukocytes and a preparation method thereof, and a leukocyte filter made of the combined filter membrane for on-line filtration of whole blood. Background technique [0002] There are many benefits to removing white blood cells during blood transfusion, and it has now become a consensus, and the most effective method is to use white blood cell filters. The first-generation white blood cell filter (1log filtration rate) can prevent non-hemolytic fever reactions; the second-generation white blood cell filter (2log filtration rate) can prevent virus infection with white blood cells as the host; the third-generation white blood cell filter (3log filtration rate), able to prevent HLA immune response. With the development of basic medicine, it has been found that the 4log filtration rate of white blood cells (tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/34A61M1/38
Inventor 戴宇东阎兵邹元国肖国锋谢伟娟
Owner NANJING RED CROSS BLOOD CENT
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