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Method for recovering N-acetyl-DL-methionine and by-products of sodium acetate trihydrate from N-acetyl-DL-methionine racemization waste liquid

A technology of methionine and sodium acetate, applied in chemical instruments and methods, preparation of carboxylate, preparation of organic compounds, etc., can solve problems such as low yield of N-acetyl-DL-methionine crystallization, energy waste, etc., and achieve environmental protection The effect of friendliness, high recovery rate and easy operation

Inactive Publication Date: 2012-08-01
天津博瑞威生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the difficult problem that N-acetyl-DL-methionine crystallization yield is not high, energy waste

Method used

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  • Method for recovering N-acetyl-DL-methionine and by-products of sodium acetate trihydrate from N-acetyl-DL-methionine racemization waste liquid

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Take 1200L of racemized waste liquid (containing 3500mol of chloride ions, 6000mol of acetate ions, and 176kg of N-acetyl-DL-methionine), adjust the pH to 3 with 30% NaOH, and concentrate under reduced pressure to 1 / 4 of the original volume. Control at 20-25°C, precipitate 180kg of sodium chloride, cool the remaining mother liquor to 0-2°C, obtain 350kg of by-product sodium acetate trihydrate, add 30% HCL to the remaining mother liquor to adjust the pH to 1, and cool down to 5-7°C, Crystals were precipitated to obtain 96 kg of N-acetyl-DL-methionine.

Embodiment 2

[0019] Take 1200L of racemized waste liquid (containing 3500mol of chloride ions, 6000mol of acetate ions, and 176kg of N-acetyl-DL-methionine), adjust the pH to 3 with 30% NaOH, and concentrate under reduced pressure to 1 / 4 of the original volume. Control at 30-35°C, precipitate 180kg of sodium chloride, cool the remaining mother liquor to 0-2°C, obtain 350kg of by-product sodium acetate trihydrate, add 30% HCL to the remaining mother liquor to adjust the pH to 1, and cool down to 5-7°C, Crystals were precipitated to obtain 90 kg of N-acetyl-DL-methionine.

Embodiment 3

[0021] 800L racemic waste liquid (its composition is 2660mol of chloride ion, 6590mol of acetate ion, 96kg of N-acetyl-DL-methionine), adjust pH to 6 with 30% NaOH, concentrate under reduced pressure to 2 / 5 of the original volume, temperature Controlled at 60-65°C, precipitated 135kg of sodium chloride, cooled the remaining mother liquor to 10-12°C, obtained 381kg of by-product sodium acetate trihydrate, added 30% HCL to the remaining mother liquor to adjust the pH to 2, and lowered the temperature to 5-7°C. Crystals were precipitated to obtain 64 kg of N-acetyl-DL-methionine.

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Abstract

The invention relates to a method for recovering N-acetyl-DL-methionine from N-acetyl-DL-methionine racemization waste liquid. The method comprises the steps as follows: (1) N-acetyl-D-methionine racemization mother liquor is adjusted through NaOH of 30 percent until the pH value ranges from 3 to 10; (2) N-acetyl-D-methionine racemization mother liquor the pH value of which is adjusted is decompressed and concentrated until the volume thereof is about a quarter to three-quarter of the original volume; (3) a lot of sodium chloride solids are separated out after decompressing concentration, andcan be removed through filtration when the temperature of mother liquor ranges from 20 to 80 DEG C; (4) filter liquor is pumped in a cooling kettle, the stirring is carried out, the temperature fallsto reach 0 to 30 DEG C, and sodium acetate trihydrate crystals are obtained through centrifugation; and (5) mother liquor without sodium acetate is adjusted through HCl of 30 percent until the pH value ranges from 1 to 3, the temperature falls to reach 5 to 7 DEG C, stirring is carried out, and N-acetyl-DL-methionine crystals are obtained through crystallization. The method has the advantages of high recovery rate and the like, is simple and convenient to operate, and is environmental-friendly. Through practical production calculation, the yield coefficient of active substances of N-acetyl-DL-methionine can reach more than 85 percent by adopting the method.

Description

technical field [0001] The invention relates to a method for recovering N-acetyl-DL-methionine from N-acetyl-DL-methionine racemization waste liquid and producing sodium acetate by-product, in particular to converting acetate ions in the waste liquid into acetic acid which can be used Sodium recovery of residual N-acetyl-DL-methionine in the effluent. Background technique [0002] L-methionine is one of the basic units of protein and the only sulfur-containing amino acid among essential amino acids. It has important physiological functions, not only participating in the transfer of methyl groups in animals, the metabolism of phosphorus, and the synthesis of adrenaline, choline, and muscle , but also the raw material for the synthesis of protein and cystine. Therefore, it is widely used in several major industries that are closely related to human life and health, such as clinical medicine, food, health products and feed. Methionine cannot be synthesized in animals and need...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C323/59C07C319/28C07C53/10C07C51/41
Inventor 闫博
Owner 天津博瑞威生物医药科技有限公司
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