Novel application of icariin to resisting of oxygen deficiency

An icariin and anti-hypoxia technology, which is applied in the directions of antitoxins, medical preparations containing active ingredients, organic active ingredients, etc. Problems such as high doses

Inactive Publication Date: 2012-09-19
周亚伟
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The dosage of total flavonoids of Epimedium is large, and the composition is complex, and the mechanism of action is not clear, so it is not suitable for patients to take for a long time

Method used

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  • Novel application of icariin to resisting of oxygen deficiency
  • Novel application of icariin to resisting of oxygen deficiency
  • Novel application of icariin to resisting of oxygen deficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Protective effect of icariin on hypoxia-induced vascular endothelial cell injury

[0029] 1. Experimental materials and methods

[0030] 1. Materials The human umbilical cord endothelial cell line ECV-304 was obtained from the American Tissue Culture Bank (ATCC CRI-1998). Icariin was provided by Peking University Shijia Research Center. DMEM medium, trypsin, and tetramethylazolazolium blue (MTT) were purchased from GIBCO, USA. Fetal bovine serum was a product of Tianjin Zhengjiang High-tech Co., Ltd. Dimethyl sulfoxide (DMSO) was purchased from Amresco. RNase and PI are products of Sigma Company. The cultured cell fluorescence staining apoptosis display kit is a product of Beijing Weiglass Co., Ltd. Hypoxic device system for French BioMé company's product. Microplate reader (Multiskan MK3) was purchased from Shanghai Leibo Analytical Instrument Co., Ltd. The UV-Vis spectrophotometer (UV-2501PC) is a product of Shimadzu Corporation, Japan. The flow c...

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PUM

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Abstract

The invention relates to a novel application of icariin to resisting of oxygen deficiency. Proved by the test in the invention, the icariin has remarkable protecting functions for resisting oxygen deficiency induction and oxygen deficiency damage. The invention also provides an application of the icariin to preparation of a medicinal preparation with an oxygen deficiency resisting function.

Description

technical field [0001] The invention relates to the application of the anti-hypoxia effect of icariin, in particular to the protective effect of icariin against hypoxia-induced vascular endothelial cell damage. Background technique [0002] Hypoxia is a pathophysiological phenomenon often involved in special environmental physiology, clinical and other fields. As a stress factor, hypoxia can cause functional damage to the respiratory system, cardiovascular system, nervous system and endocrine system. Among them, the nervous system is particularly sensitive to hypoxia, and its damage mechanism is more complicated. [0003] The commonly used western medicines for anti-ischemia and hypoxia mainly include calcium channel blockers, free radical scavengers and some central nervous system inhibitors. Although these drugs have obvious effects, they have relatively serious side effects. In recent years, the role of traditional Chinese medicine in anti-hypoxic injury has gradually a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P39/00
Inventor 周亚伟
Owner 周亚伟
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