Breast cancer molecular marker miR-30c-1-3p

Abstract

The invention provides a breast cancer molecular marker miR-30c-1-3p and application thereof in preparing a diagnostic reagent for diagnosis of a breast cancer. The content of the miR-30c-1-3p in serum of a breast cancer patient is larger than the content of the miR-30c-1-3p in serum of a normal human, and after the patient gets surgery, the content of the miR-30c-1-3p in the serum can be back toa normal level. The invention also provides a diagnostic kit for diagnosis of the breast cancer. The breast cancer molecular marker miR-30c-1-3p is used for diagnosis of the breast cancer, so that the characteristics of simplicity in operation, convenience in acquiring materials, safety, no injury, high specificity, high sensitivity and easiness in screening in quantity are realized.

Description

technical field [0001] The present invention relates to the field of tumor diagnosis, in particular to a breast cancer molecular marker miR-30c-1-3p, which can be applied to the screening of breast cancer high-risk groups, identification of breast cancer, monitoring of breast cancer treatment status and breast cancer Cancer prognosis monitoring and other fields. Background technique [0002] microRNA (miRNA) is a research hotspot in recent years. It is a single-stranded small molecule RNA widely present in eukaryotes. It has no coding function, but it can bind to the flanking region of the gene sequence to repress or inhibit the translation of target mRNA. , with a high degree of conservation, timing and tissue specificity. In 2008, Mitchell et al. first discovered that many miRNAs stably exist in plasma, and the level of miR-141 can be used as a diagnostic marker for prostate cancer. Subsequent studies also discovered miR-92a, a diagnostic marker for colon cancer, and miR...

AI Technical Summary

Problems solved by technology

Mammography is simple, convenient, non-invasive, and low-cost. It is one of the preferred methods for breast cancer screening. It displays the size, number, location, density, edge, shape, presence of calcification, and calcification of the tumor. The shape, size, number, steps, and surrounding halos and skin changes provide localization and qualitative signs and determine the nature of the lesion; its limitations are: (1) When the patient's breast glands are abundant, they overlap with the lesion and cannot Show the whole picture of the lesion, even false negative, (2) It is easy to miss the diagnosis of small tumors close to the chest wall and dense breast, (3) Sometimes it cannot provide a clear qualitative diagnosis

Although some studies have been carried out in this field, the accuracy and sensitivity of the existing miRNA markers are insufficient, and there is still a need to find more accurate and sensitive breast cancer miRNA markers in clinical and research

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