Chinese medicinal composition for gastroenteropathy and preparation method thereof
A composition and technology for gastroenterology, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of little technical inspiration, no research, unstable drug efficacy, etc., and achieve less adverse reactions, The effect of saving time and promoting the recovery of gastrointestinal function
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Embodiment 1
[0033] Example 1: Preparation of Huangbai Tunqi Granules
[0034] 1. Prescription:
[0035]
[0036] 2, the preparation of Chinese medicine composition:
[0037] 1) Grind the commercially available rhubarb, Magnolia officinalis, Citrus aurantium and Atractylodes macrocephala into the coarsest powder according to the above prescription amount (that is, the powder that can pass through the No. 1 sieve, but mixed with no more than 20% of the powder that can pass through the No. 3 sieve), spare;
[0038] 2) Mix the crushed medicinal material powder, use 8 times the weight of 80% (V / V) ethanol to heat and reflux at 65~80°C for 1.5 hours, filter, and use 6 times the weight of 80% (V / V) for the filter residue Heat and reflux extraction with ethanol at 65-80°C for 1 hour, filter, combine the filtrates from the two extractions to obtain the alcohol extract;
[0039] 3) Concentrate the alcohol extract under reduced pressure to a thick paste with a relative density of 1.30~1.35 (me...
Embodiment 2
[0044] Embodiment two: the pharmacodynamic experiment of Chinese medicine composition
[0045] 1. Functional recovery test of small intestine in rabbits after abdominal surgery
[0046] Get the Chinese medicine composition that the mode that embodiment one records obtains to the rabbit after abdominal operation by the dosage of 6, 3, 1g / kg (dosage is all based on the total weight of these four kinds of raw materials of rhubarb, magnolia officinalis, citrus aurantii and Atractylodes macrocephala, The same below) was given by intragastric administration, and a pre-test was carried out. After 6 days of administration, it was found that both the doses of 6 and 3g / kg could accelerate the recovery of gastrointestinal motility after abdominal surgery. Therefore, according to the results of the pre-test, three dosages of high, medium and low were proposed. Intragastric administration (see Table 1 for the specific dosage regimen), by observing the effect of the traditional Chinese medi...
Embodiment 3
[0095] Embodiment three: animal acute toxicity experiment of Chinese medicine composition
[0096] Rat gavage administration acute toxicity test: get the Chinese medicine composition that the mode of embodiment one records obtains by the speed of 114g / kg / 24h (wherein dosage is all based on the total of these four kinds of raw materials of rhubarb, magnolia officinalis, citrus aurantii and Atractylodes macrocephala). Weight, the same below) was administered to rats (equivalent to 109 times the clinical dose), and the symptoms of toxic reactions were diarrhea, loose stools and decreased food intake, but they basically returned to normal after 72 hours, and no other obvious toxic reactions were found.
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