Suppository for treating prostatitis and preparation method thereof

A technology for prostatitis and suppositories, which is applied in suppository delivery, medical preparations containing non-active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of strong toxic and side effects of oral preparations, increased pharmaceutical costs, and large gastric irritation

Inactive Publication Date: 2012-09-26
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tamsulosin hydrochloride is one of the specific drugs for the treatment of prostatitis, but its oral preparations have strong toxic and side effects. While producing therapeutic effects, it is highly irritating to the stomach - it can cause gastric ulcers
Nowadays, enteric-coated tablets or sustained-release capsules are mostly used to reduce the irritation to the stomach, but this also increases the cost of pharmaceuticals virtually.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Get Phellodendron Phellodendron 500g, get Andrographis paniculata 500g in addition, pulverize after mixing, add 5-10 liters of 95% (v / v) ethanol and soak for 24 hours, add water heating reflux to extract the bulk drug soaked 2 times, each 1- 2 hours; add ethanol (60%-90% ethanol of 5-8 times the weight of medicinal residues) to the medicinal residues extracted by the above water and extract them under reflux for 2 times, each time for 1-2 hours (timing after boiling); two parts of the solution Recover the solvent separately, and then mix the extract; take 40g of dried blood, grind it into powder, and pass through an 80-mesh sieve; take another 30g of tamsulosin hydrochloride, mix and grind it with a suitable amount of molten suppository base as usual, and make a suppository.

Embodiment 2

[0023] Embodiment 2: get Phellodendron Phellodendri 1000g, get Andrographis paniculata 1000g in addition, pulverize after mixing, add 10-15 liters of 95% (v / v) ethanol and soak for 24 hours, the raw material drug that soaks is added water heating reflux to extract 2 times, each 1- 2 hours; add ethanol to the dregs of the above-mentioned water extraction and heat and reflux extraction twice, each time for 1-2 hours (timing after boiling); the two parts of the solution recover the solvent respectively, and then mix the extract; take 70g of dried blood and make powder, Sieve through an 80-mesh sieve; take another 40 g of tamsulosin hydrochloride, mix and grind the extract, dried blood and an appropriate amount of suppository base to make a suppository.

Embodiment 3

[0024] Embodiment 3: Get Phellodendron Phellodendri 1500g, get Andrographis paniculata 1500g in addition, pulverize after mixing, add 15-20 liters of 95% (v / v) ethanol and soak for 24 hours, the raw material drug that soaks is added water heating reflux to extract 2 times, each 1- 2 hours; add ethanol to the dregs of the above-mentioned water extraction and heat reflux to extract twice, each time for 1-2 hours (timing after boiling); the two parts of the solution recover the solvent respectively, and then mix the extract; Pass through an 80-mesh sieve; take another 50 g of tamsulosin hydrochloride, mix and grind the extract, dried blood and an appropriate amount of suppository base to make a suppository.

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PUM

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Abstract

The invention discloses a suppository for treating prostatitis and a preparation method thereof. The suppository is prepared from the following raw material drugs in parts by weight: 0.3 to 0.5 part of tamsulosin Hydrochloride, 5 to 15 parts of golden cypress, 5 to 15 parts of common andrographis herb, 0.4 to 1 part of dragon blood, and 100 parts of 36 type mixed fatty acid glyceride. The suppository is administrated from the anus, and is pushed into rectum for half finger; the dosage of the suppository for an adult is 5 to 8g per time and the suppository is taken 1 to 2 times everyday, 30 continuously administrated days are taken as a course of treatment, and the total effective rate in 30 cases with chronic prostatitis treated with the suppository for one course of treatment is 94.8 percent.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a fat-soluble suppository administered through the anus and a preparation method thereof, which is used for treating prostatitis, especially has good curative effect on urinary disorders caused by prostatitis. Background technique [0002] Prostatitis is a common and frequently occurring disease of the male urinary system. Long-term prostatitis may lead to the occurrence of uremia. Now, prostatitis has a high incidence rate among middle-aged and elderly men in my country, and the incidence rate of elderly men over 60 years old is more than 40%, which has caused a great impact on the life and health of patients. Tamsulosin hydrochloride is one of the specific drugs for treating prostatitis, but its oral preparation has strong toxic and side effects, and it is highly irritating to the stomach while producing a therapeutic effect—it can cause gastric ulcers. Nowadays, enteric-coat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K9/02A61K47/14A61P13/08A61K31/18
Inventor 张起辉杨亚楠闫政清王瑾蒋壁蔚
Owner CHONGQING UNIV
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