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Method for performing hydrophilic modification on polyacrylate or copolymer thereof, and product and application of polyacrylate or copolymer thereof

A polyacrylate, hydrophilic modification technology, applied in chemical instruments and methods, other chemical processes, chemical/physical processes, etc., can solve the problem that the separation medium cannot be further derivatized

Active Publication Date: 2012-09-26
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the surface hydrophilic modification of PGMA-DVB microspheres reported in the literature is to hydrolyze the epoxy groups on the surface into dihydroxyl groups under acidic or alkaline conditions, so as to enhance the polarity of the surface of the material in order to obtain better hydrophilicity (JunfaYin , Gengliang Yan, Hailin Wang, Yi Chen, Macroporous polymer monolithsfabricated by using a metal-organic coordination gel template, Chem Commun, 2007, 44:4614-4616); The surface of glycidyl methacrylate (PGMA) material is coupled with hydrophilic macromolecule polyethylene glycol (PEG), and the modified PGMA microspheres can be applied to the separation and purification of biological macromolecules under the mode of hydrophobic interaction chromatography, but Cannot be further derived into other series of separation media

Method used

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  • Method for performing hydrophilic modification on polyacrylate or copolymer thereof, and product and application of polyacrylate or copolymer thereof
  • Method for performing hydrophilic modification on polyacrylate or copolymer thereof, and product and application of polyacrylate or copolymer thereof
  • Method for performing hydrophilic modification on polyacrylate or copolymer thereof, and product and application of polyacrylate or copolymer thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1) Super-large pore PGMA-DVB microspheres pretreated in DMSO

[0066] Accurately weigh 1.0 g of PGMA-DVB microspheres into a 50 mL Erlenmeyer flask, then add 10 mL of DMSO, shake in a 120 rpm shaker for 2 hours at room temperature, then perform suction filtration and wash with the same volume of DMSO. After washing, remove the solvent Suction filtration until there is no obvious solvent on the surface of the microspheres.

[0067] 2) PEI bonded to the surface of PGMA-DVB microspheres (Mw=1800)

[0068] Weigh 1.0g PEI and put it into a 100mL three-neck bottle, then add 50mL DMSO to it, under mechanical stirring at 120rpm, add the microspheres after swelling treatment in step 1) in Example 1, raise the temperature to 80°C, and keep the reaction at this temperature After 24 hours, after the reaction, use a G4 sand core funnel to filter under reduced pressure, and at the same time wash with 500mL of 80°C hot water until the washing liquid is neutral.

[0069] 3) Reinforceme...

Embodiment 2

[0074] 1) Super-large pore PGMA-DVB microspheres pretreated in DMSO

[0075] Accurately weigh 1.0 g of PGMA-DVB microspheres into a 50 mL Erlenmeyer flask, then add 20 mL of DMSO, shake at room temperature on a 120 rpm shaking shaker for 2 hours, perform suction filtration, and wash with the same volume of DMSO. After washing, the solvent Suction filtration until there is no obvious solvent on the surface of the microspheres.

[0076] 2) ethylenediamine bound to the surface of PGMA-DVB microspheres

[0077] Weigh 2.0g of ethylenediamine into a 100mL three-neck flask, then add 50mL of DMSO to it, under mechanical stirring at 120rpm, add the microspheres after swelling treatment in step 1) in Example 2, heat up to 60°C, at this temperature Keep the reaction for 24 hours. After the reaction, use a G4 sand core funnel to filter under reduced pressure, and at the same time wash with 500mL deionized water until the washing liquid is neutral.

[0078] 3) Reinforcement of PGMA-DVB m...

Embodiment 3

[0083] 1) Pretreatment of ultra-large pore PGMA-DVB microspheres in DMF

[0084] Accurately weigh 1.0 g of PGMA-DVB microspheres into a 50 mL Erlenmeyer flask, then add 15 mL of DMF, shake at room temperature on a 120 rpm shaking shaker for 2 hours, perform suction filtration, and wash with the same volume of DMF. After washing, the solvent Suction filtration until there is no obvious solvent on the surface of the microspheres.

[0085] 2) Diethylenetriamine bonded to the surface of PGMA-DVB microspheres

[0086] Weigh 1.0g of diethylenetriamine and put it into a 100mL three-necked flask, then add 50mL of DMSO to it, under mechanical stirring at 120rpm, add the microspheres after the swelling treatment in step 1) in Example 3, and heat up to 70°C. Keep the reaction for 24 hours. After the reaction is over, filter under reduced pressure with a G4 sand core funnel while it is hot, and wash with 500mL deionized water until the washing liquid is neutral.

[0087] 3) Reinforcemen...

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Abstract

The invention discloses a method for performing hydrophilic modification on the surface of polyacrylate or a copolymer material thereof. The method comprises the following steps of: 1) performing swelling on polyacrylate or the copolymer material thereof by using an organic solvent; 2) chemically bonding hydrophilic polyamine substance onto the surface of the material treated in the step 1) in the presence of the solvent by covalent bonds; 3) crosslinking and reinforcing the hydrophilic polyamine substance on the surface of the material, which is obtained in the step 2); and 4) performing quaterisation on the hydrophilic substance on the surface of the material, which is obtained in the step 3), in the presence of the solvent by using quaternary ammonium salt biochemical reagent. The method can be applied to the surface modification of most polymer materials, particularly superporous polymer microspheres, and the polymer microspheres which are subjected to hydrophilic modification can be applied to the field of biotechnologies and chromatographic separation.

Description

technical field [0001] The present invention relates to the field of modification of polymer materials, in particular, the present invention relates to a method for making the surface of polymer materials hydrophilic and its products, as well as its application in the field of biotechnology and chromatographic separation, especially in biochemical chromatographic separation. Specifically, the present invention relates to a method for hydrophilic modification of polyacrylates or their copolymers and its products and applications in the fields of biotechnology and chromatographic separation, especially for the surface of ultra-macroporous polyacrylate microsphere materials Hydrophilicization and its products and applications. Background technique [0002] As a biochemical separation medium, polymer microspheres have the advantages of high mechanical strength, stable chemical properties, good acid and alkali resistance, and can be operated under high pressure, so they have a go...

Claims

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Application Information

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IPC IPC(8): C08F20/32C08F220/32C08F212/36C08F265/04C08F8/44C08F8/32C08J3/24C08J9/36C08J7/12C08J7/02C08L33/14C08L51/00B01J20/285B01J20/30B01D15/08
Inventor 马光辉张荣月苏志国周炜清李娟
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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