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Method for adjusting buffering nerve stimulation parameters

A technology for buffering nerves and stimulating frequency, which is applied in the field of medical experiments, and can solve problems such as long time for adjusting stimulation parameters, complicated operation, and affecting experimental results.

Inactive Publication Date: 2012-10-03
新乡医学院第二附属医院
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AI Technical Summary

Problems solved by technology

However, due to its complicated operation, it is often difficult to obtain ideal experimental results. Too small stimulation intensity and frequency will not cause blood pressure to drop, while too high stimulation intensity and frequency will cause blood pressure to drop, but it will cause nerve damage.
At present, there is no report on the appropriate stimulation parameters for stimulating the central end of the buffer nerve at home and abroad.
In addition, in actual operation, because the appropriate range of stimulation parameters is not known, it often takes a long time to adjust the stimulation parameters, which affects the experimental results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] 1. Grab, weigh, anesthetize, fix

[0016] Grab the rabbit, weigh it, and slowly inject 20% ethyl carbamate at a dose of 1 gram per kilogram of body weight through the ear vein. The sign of animal anesthesia is the disappearance of the toe pinch reflex. After anesthesia, the animal was fixed in the dorsal position on the operating table with a rope for operation.

[0017] 2. Neck surgery

[0018] Use rough scissors to cut off the rabbit hair in the surgical field, incise the skin 6-7 cm along the midline of the neck, separate the subcutaneous tissue and muscle along the midline with a hemostat, expose the trachea and free the trachea for 2-3 cm, and thread it under the trachea for later use . Clamp the skin and muscle edges on both sides of the trachea with two hemostats, and pull them to both sides, and you can see the left and right common carotid arteries parallel to the trachea on both sides of the trachea and a bundle of them Nerves, which include the vagus nerve...

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PUM

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Abstract

The invention discloses a method for adjusting and buffer nerve stimulation parameters in leporid arterial blood pressure adjusting experiments. The method is characterized in that buffer nerve is ligated doubly and sheared from the middle, and the proximal end and the peripheral end of the buffer nerve are stimulated with the stimulus intensity of 0.81 plus or minus 0.21v and with the stimulus frequency of 25.39 plus or minus 6.81Hz.

Description

technical field [0001] The invention relates to the field of medical experiment methods, in particular to a method for adjusting buffer nerve stimulation parameters. Background technique [0002] Arterial blood pressure is an important indicator of the circulatory system, which is mainly affected by factors such as stroke volume, heart rate, peripheral resistance, the ratio of circulating blood volume to vascular volume, and the elasticity of the aortic wall. In medical teaching, arterial blood pressure regulation experiments can be used to screen drugs, compounds, and monomers that have blood pressure regulation effects. Through arterial blood pressure regulation experiments, you can learn the direct measurement method of arterial blood pressure, and observe the regulation of arterial blood pressure by nerve and humoral factors and their influencing factors. The buffer nerve, also known as the decompressor nerve, is formed by a single bundle in the neck of the afferent ner...

Claims

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Application Information

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IPC IPC(8): A61N1/36
Inventor 张瑞岭杜爱林孟莉姜洪波李新娟王莉盛海燕刘晓丽杨俊路承彪李东亮连阳阳余意沈慧安娜徐磊宦楠楠洪渊赵东海
Owner 新乡医学院第二附属医院
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