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A kind of microemulsion that forms nanoemulsion in situ and preparation method thereof

A nano-emulsion and micro-emulsion technology, applied in mixing methods, chemical instruments and methods, dissolution and other directions, can solve the problems of high cost, easy to contaminate preparations, and high energy consumption, and achieve easy transportation, good stability, and narrow particle size distribution. Effect

Active Publication Date: 2014-10-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The traditional preparation methods of nanoemulsions are mainly high-pressure homogenization and ultrasonic methods. Although they can be mass-produced, they consume high energy and cost, and are easy to contaminate the preparations, and the stability of the prepared nanoemulsions is poor.

Method used

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  • A kind of microemulsion that forms nanoemulsion in situ and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Based on 100 parts by weight, 76 parts of white oil, 8.36 parts of Span80, 10.64 parts of Tween80, and 5 parts of water are taken, of which 19 parts of Span80 and Tween80 are taken, and the weight ratio of the two is 11:14. Then put them in the reactor and mix them uniformly, and stir at 500 rpm for 5 minutes at room temperature to form a microemulsion that forms a nanoemulsion in situ.

[0019] The high-temperature stability, long-term stability, and low-temperature stability of the prepared in-situ synthesized nanoemulsion were investigated according to the following methods, and the particle size distribution of the in-situ formed nanoemulsion after dilution:

[0020] 1. Stability measurement:

[0021] Long-term stability: The product is placed statically for a long time, observe the appearance, and pay attention to whether there is clear delamination.

[0022] High temperature stability: Place the sample in a 70°C incubator for 5 hours and observe the appearance to see if ...

Embodiment 2

[0031] Based on 100 parts by weight, take 45 parts of liquid paraffin, 19.8 parts of Span80, 25.2 parts of Tween80, 3.5 parts of NaCl, and 6.5 parts of water, of which Span80 and Tween80 are 45 parts, and the weight ratio between the two is 11:14 (0.7857). Dissolve 3.5 parts of NaCl in 6.5 parts of water to obtain the water phase; then mix 45 parts of liquid paraffin, 19.8 parts of Span80 and 25.2 parts of Tween80 with the prepared water phase in the reactor, and stir at 400 rpm at room temperature for 10 It can be made into a microemulsion that forms a nanoemulsion in situ within minutes.

[0032] The detection was carried out according to the method described in Example 1, and the results are as follows:

[0033] Appearance

Embodiment 3

[0035] Based on 100 parts by weight, take 72 parts of liquid paraffin, 7.92 parts of Span80, 10.08 parts of Tween80, 1 part of D230, 1 part of NaCl and 8 parts of water. Among them, there are 18 parts of Span80 and Tween80. The weight ratio of the two is 11:14 ( 0.7857). Dissolve 1 part of D230 and 1 part of NaCl in 8 parts of water to obtain the water phase; then mix 72 parts of liquid paraffin, 7.92 parts of Span80 and 10.08 parts of Tween80 with the prepared water phase in the reactor and mix it evenly at room temperature at 200 rpm Stirring at a rotation speed of 10 minutes per minute can be made into a microemulsion that forms a nanoemulsion in situ.

[0036] The detection was carried out according to the method described in Example 1, and the results are as follows:

[0037] Appearance

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Abstract

The invention provides a micro-emulsion for forming a nano-emulsion in situ and a preparation method of micro-emulsion. Every 100 parts by weight of the micro-emulsions comprise the following components in parts by weight: 45-76 parts of an oil phase, 19-50 parts of a nonionic surfactant, 0-3.5 parts of an inorganic salt, 0-3.5 parts of a surfactant aid and the balance of water. The preparation method comprises the following steps of: proportionally weighing each component respectively; dissolving the weighed oil phase and inorganic salt into water; and stirring at the rotating speed of 50-500 revolutions per minute at the normal temperature for 5-20 minutes, and standing. The micro-emulsion for forming the nano-emulsion in situ, prepared with the method, is a transparent or semitransparent liquid, is narrow in particle diameter distribution, has very high long-term stability, high-temperature stability and low-temperature stability, is consistent with the requirement of environmental protection and various industrial requirements, and is easy to transport. A nano-emulsion which has high stability and can be stored for a long time can be formed in situ by using the micro-emulsion.

Description

Technical field [0001] The invention relates to a microemulsion capable of synthesizing a nanoemulsion in situ and a preparation method of the microemulsion, belonging to the technical field of nanoemulsion preparation. Background technique [0002] Compared with ordinary emulsions, nanoemulsions have small droplets in particle size, uniform dispersion, and certain dynamic stability. They can avoid obvious flocculation and coalescence for several months or even years. They are used in oil exploration, medicine, food, and construction energy conservation. , Concrete water-saving curing, agriculture, papermaking, wood-based panels, special ceramics, light industry and other fields can be better widely used. [0003] The traditional preparation methods of nanoemulsions are mainly high-pressure homogenization and ultrasonic methods. Although they can be mass-produced, they have high energy consumption, high cost, and easily pollute the preparation, and the prepared nanoemulsions have p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F3/08
Inventor 孙德军童坤郝京诚崔迎春梅贞
Owner SHANDONG UNIV
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