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Experiment method for eluent regeneration in chromatographic column preparation and organic matter separation experiment

A technology for separation experiment and organic matter, applied in the field of chromatographic separation, it can solve the problems of environmental hazards, serious corrosion effect, and not completely solved, and achieve the effect of saving costs, strengthening environmental protection awareness, and simple and economical solutions.

Inactive Publication Date: 2012-10-03
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Methanol and chloroform are toxic and volatile compounds that can pollute air, soil, rivers, and groundwater. Improper disposal will bring great harm to the surrounding environment
Chloroform is an organic solvent, which has a serious corrosion effect on ordinary plastic drainage pipes, and will cause serious deformation and cracking of weld seams in pipes
[0007] These two articles have not completely solved the problem
In addition, there is no other effective and thorough method for treating the waste liquid so far

Method used

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  • Experiment method for eluent regeneration in chromatographic column preparation and organic matter separation experiment
  • Experiment method for eluent regeneration in chromatographic column preparation and organic matter separation experiment
  • Experiment method for eluent regeneration in chromatographic column preparation and organic matter separation experiment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] a. Take the first elution waste liquid and place it in a single-necked flask, install a three-way distillation head, insert a thermometer above the three-way distillation head and seal it with a rubber plug, and connect the side port to a condenser;

[0048] b. The condensation pipe is connected to the single-port recovery bottle through the liquid connection pipe to recover the distillate;

[0049] c. Heat the single-necked flask in an oil bath or water bath. The temperature of the oil bath or water bath is controlled at 80±1°C, and heated to vaporization;

[0050] d. Keep the temperature of the oil bath at 80±1°C until the end of distillation, and cut off all fractions at 53°C to 65°C.

[0051] E, take the cut that reclaims, calculate the rate of recovery of the first elution waste liquid;

[0052] f, respectively get analytically pure methanol and chloroform to measure with a gas chromatograph, and record the retention time respectively;

[0053] G, the recovery test...

Embodiment 2

[0057] Repeat steps a and b in Example 1;

[0058] c. Place the single-necked flask in an oil bath or water bath to heat it. The temperature of the oil bath or water bath is controlled at 83±1°C, and heated to vaporization;

[0059] d. Keep the temperature of the oil bath at 83±1°C until the end of distillation, and cut off all fractions at 53°C to 65°C;

[0060] Repeat e~i step among the embodiment 1.

Embodiment 3

[0062] Repeat steps a and b in Example 1;

[0063] c. Place the single-necked flask in an oil bath or water bath to heat it. The temperature of the oil bath or water bath is controlled at 85±1°C, and heated to vaporization;

[0064] d. Keep the temperature of the oil bath at 85±1°C until the end of distillation, and intercept all fractions at 53~65°C;

[0065] Repeat e~i step among the embodiment 1.

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Abstract

The invention discloses chromatographic column preparation and an experiment method for elution waste solution regeneration in an organic separation experiment, and relates to the technical field of chromatography. The elution waste solution produced during chromatographic column preparation and organic matter separation experiment is mixed solution which contains methanol, trichloromethane and trace organic matters. Since the methanol and the trichloromethane are toxic compounds, if the methanol and the trichloromethane are not properly treated, a very great harm is caused to surrounding environments. The chromatographic column preparation and the experiment method for elution waste liquid regeneration in the organic separation experiment are characterized in that a first elution waste solution and a second elution waste solution generated in the in the chromatographic column preparation and the organic separation experiment are regenerated by a constant pressure oil bath distillation method. The chromatographic column preparation and the experiment method for elution waste solution regeneration in the organic separation experiment have the beneficial effects that the waste solution recovery rate is more than 99.3 percent and the social benefits are remarkable; a drainage system in a laboratory is prevented from being corroded by the trichloromethane which is an organic solvent; the expenses in chemical waste treatment are saved; the method is simple and economic and the used instruments and equipment are existing conventional instruments which are available in the laboratory.

Description

technical field [0001] The invention relates to the technical field of chromatographic separation, in particular to the technical field of preparation of chromatographic columns, separation of organic matter and regeneration of elution waste liquid. Background technique [0002] Chromatographic column preparation and organic separation experiment is one of the experimental courses for students majoring in pharmaceutical engineering, chemical technology, biotechnology, pharmaceutical preparations, etc. in colleges and universities. [0003] In the chromatographic column preparation and organic matter separation experiments, two eluents need to be prepared. The first eluent is "methanol: trichloromethane solution with a weight ratio of 1:9", and the second eluent is "methanol: trichloromethane". The mixed sample of "methyl red and bromocresol green solution" was eluted separately by the solution with the weight ratio of 1:1 of methyl chloride. Correspondingly produce two wast...

Claims

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Application Information

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IPC IPC(8): C02F1/04
Inventor 马晶许崇娟戚玉华张燕霞
Owner UNIV OF JINAN
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