Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel polytetrafluoroethene (PTEF) nanocrystallization artificial blood vessel and preparation method thereof

A polytetrafluoroethylene, artificial blood vessel technology, applied in the fields of medical science, prosthesis, coating, etc., can solve the problems of unreported preparation methods, and achieve the purpose of reducing the degree of vascular intimal hyperplasia, improving the patency rate, and improving the curative effect. Effect

Inactive Publication Date: 2012-10-03
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about a new type of polytetrafluoroethylene nano-artificial blood vessel and its preparation method.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel polytetrafluoroethene (PTEF) nanocrystallization artificial blood vessel and preparation method thereof
  • Novel polytetrafluoroethene (PTEF) nanocrystallization artificial blood vessel and preparation method thereof
  • Novel polytetrafluoroethene (PTEF) nanocrystallization artificial blood vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 PTFE-MWNT

[0039] 1 experiment

[0040] 1.1 Raw materials and reagents

[0041] MWNTs (Shenzhen Nanometer Port Co., Ltd.) with a purity greater than 90% were used directly. PDDA solution (molecular weight: 200,000-350,000, Sigma-Aldrich, USA) was prepared into a 15 mg / ml ion solution. PTFE is taken from PTFE artificial blood vessel material imported from the United States, rubbed with sandpaper and treated with acetone and cut into 1cm 2 Use directly after size. Other chemicals and reagents were of analytical grade. The water used in the experiment was deionized water.

[0042] 1.2 Functionalization of MWCNTs

[0043] First, the MWNTs were dispersed in concentrated H 2 SO 4 / concentrated HNO 3 (3 / 1, v / v) in the mixed solution and stirred at 70°C for 4h. Then the obtained MWNT-COOH was repeatedly washed with water until neutral, and dried under vacuum at 70 °C for 12 h. Next, dry MWNT-COOH was added to SOCl at 70 °C 2 Stirr...

Embodiment 2

[0063] The animal experiment of embodiment 2 PTFE-MWNT

[0064] 1. Materials and methods

[0065] 1. Production of PTFE-MWNT

[0066] 1.1 Functionalization of multi-walled carbon nanotubes

[0067] MWNTs (Shenzhen Nanoport Co., Ltd.) dispersed in concentrated H 2 SO 4 / concentrated HNO 3 (3 / 1, v / v) in the mixed solution and stirred at 70°C for 4h. Then the obtained MWNT-COOH was repeatedly washed with water until neutral, and dried under vacuum at 70 °C for 12 h. Next, dry MWNT-COOH was added to SOCl at 70 °C 2 Stirred and refluxed for 24 hours, evaporated the remaining SOCl after the reaction was complete 2 , immediately adding the acyl chlorided MWNTs to NH 2 (CH 2 ) 2 NH 2 , stirred and refluxed at 70°C for 48h. Then the obtained MWNT-NH 2 Filter and wash several times, and vacuum-dry at 70°C for 24 hours for later use.

[0068] 1.2 Self-assembled MWNT films layer by layer on PTFE substrates

[0069] Combine dry MWNT-COOH with MWNT-NH 2 The powder was dis...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Surface potentialaaaaaaaaaa
Login to View More

Abstract

The invention relates to a novel polytetrafluoroethene (PTEF) nanocrystallization material and a preparation method thereof. According to the preparation method for the novel material, functional multiwalled carbon nanotube (MENT) thin films are self-assembled on PTEF substrates layer by layer. The invention also provides a novel PTEF nanocrystallization artificial blood vessel and a preparation method thereof. The preparation method has the advantages that the MENT thin films are self-assembled on the PTEF substrates which are pre-treated by phthalic diglycol diacrylate (PDDA), so that the performance of the substrate materials can be improved well by the simple and convenient preparation method, and the MENT thin films which are self-assembled layer by layer by taking PTEF as the substrates can be widely applied; and the MENTs can be combined with PTEF blood vessel materials which are clinically used on large scale at present, the degree of intimal hyperplasia of the blood vessels, which is caused after implantation of artificial blood vessels can be reduced, the patency rate of the blood vessels is improved, and a feasible method is provided for improving the curative effect of the implantation operation of the artificial blood vessels clinically.

Description

technical field [0001] The invention relates to an artificial blood vessel and a preparation method thereof, in particular to a novel polytetrafluoroethylene nanoartificial blood vessel and a preparation method thereof. Background technique [0002] Since their discovery in 1991, carbon nanotubes (CNTs) have attracted extensive attention due to their excellent mechanical, thermal, chemical and electrical properties. As a novel one-dimensional nanomaterial, CNTs have broad application prospects in many fields such as field emission, nanoelectronic devices, nanomachines, composite reinforcement materials, hydrogen storage materials, and biomedicine. [0003] CNTs are one of the most ideal materials for preparing functional thin films. In recent years, polymer nanocomposites based on CNTs have been developed to a certain extent, but due to the strong van der Waals force between CNTs, CNTs are prone to agglomeration and precipitation in solution, which largely limits the use of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J7/06C08L27/18A61L27/40
Inventor 梅举鲍春荣
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com