Synthetic polyisoprene rubber plug for injection and preparation method thereof

A technology of polyisoprene rubber stopper and polyisoprene, which is applied in the direction of hypodermic injection devices, etc., can solve problems such as poor resilience, leakage of liquid when pulling out needles, waste of labor and energy consumption, etc., and achieve good elasticity, Stable performance and good sealing effect

Inactive Publication Date: 2012-10-03
QINGDAO HUAREN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above two rubber plug materials have certain deficiencies and cannot fully meet the needs of use, specifically:
[0004] First: The butyl rubber stopper has good chemical stability, but it is easy to produce debris when punctured, has poor resilience, and is prone to needle withdrawal and leakage, which leads to complaints from hospital medical staff and patients;
[0005] Second, the isoprene rubber gasket has good resilience, sealing and puncture and chip resistance, but the chemical properties of the isoprene rubber in the current product cannot meet the quality standards for rubber plugs used in d

Method used

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  • Synthetic polyisoprene rubber plug for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0040] Specifically, the preparation method of the above-mentioned synthetic polyisoprene rubber stopper for injection comprises the following steps:

[0041] a. Weighing and Banburying: Weigh the raw materials, put the weighed isoprene rubber in the Banbury mixer, first perform semi-compression plasticizing, then full-pressure plasticizing, and then add stearic acid, titanium dioxide and carbon Black is used for rubber mixing, then clay and white carbon black are added for rubber mixing and material sweeping. Specifically, it includes: open the mixer to heat up, and when the temperature of the mixing chamber rises to 38°C±1°C, put in isoprene rubber, first half-press and plasticate for 30 seconds±5 seconds, and then fully press and plasticate for 60 seconds±1°C. 5 seconds; add stearic acid, titanium dioxide and carbon black, mix for 90 seconds ± 5 seconds; add clay, white carbon black, mix for 60 seconds ± 5 seconds, and then sweep the material, after the sweep is completed, ...

Example Embodiment

[0051] Example 1

[0052] Weigh 61.24% isoprene rubber, 24.49% clay, 0.55% stearic acid, 7.35% silica, 5.42% titanium dioxide, 0.24% carbon black and 0.61% peroxide curative, Preparation of synthetic polyisoprene rubber stopper products.

[0053] The specific process flow is as follows:

[0054] a1. Weighing and Banburying: Weigh the raw materials, turn on the Banbury mixer to heat up, and when the temperature of the Banbury chamber rises to 38°C, put in isoprene rubber, first half-press and plasticize for 30 seconds, and then fully press and plasticize. 60 seconds; add stearic acid, titanium dioxide and carbon black, and mix for 90 seconds; add clay and white carbon black, and sweep the material after 60 seconds of mixing. After sweeping, continue mixing for 60 seconds; open the mixer room The mixed rubber is discharged, and the discharge temperature is about 40 °C;

[0055] b1. Kneading and extrusion: Turn on the mill to heat up, and when the temperature rises to 52°C, pu...

Example Embodiment

[0062] Example 2

[0063] Weigh 70% isoprene rubber, 20% clay, 0.4% stearic acid, 7% silica, 1.9% titanium dioxide, 0.2% carbon black and 0.5% peroxide curative, Preparation of synthetic polyisoprene rubber stopper products.

[0064] The specific process flow is as follows:

[0065] a1. Weighing and Banburying: Weigh the raw materials, turn on the Banbury mixer to heat up, and when the temperature of the Banbury chamber rises to 39°C, put in isoprene rubber, first half-press and plasticate for 35 seconds, and then fully press and plasticate. 65 seconds; add stearic acid, titanium dioxide and carbon black, and mix for 95 seconds; add clay and white carbon black, and sweep the material after 65 seconds of mixing. After sweeping, continue mixing for 65 seconds; open the mixer room The mixed rubber is discharged, and the discharge temperature is about 43 °C;

[0066] b1. Kneading and extrusion: Turn on the mill to heat up, and when the temperature rises to 55°C, put the mixed r...

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Abstract

The invention relates to a synthetic polyisoprene rubber plug for an injection and a preparation method thereof. The synthetic polyisoprene rubber plug for the injection comprises the flowing components in percentage by weight: 61.24-76.22 percent of isoprene rubber, 15.24-24.49 percent of pottery clay, 0.30-0.55 percent of stearic acid, 6.1-7.35 percent of white carbon black, 1.52-5.42 percent of titanium dioxide, 0.15-0.24 percent of carbon black and 0.46-0.61 percent of peroxide vulcanizing agent. According to the synthetic polyisoprene rubber plug disclosed by the invention, due to the adoption of a peroxide vulcanizing system, an isoprene rubber product is prepared from a raw material without sulfur; the final rubber plug product cannot generate a sulfur-containing substance; and the produced isoprene rubber product can be directly contacted with medicines for use and has the advantages of stable performance, puncture resistance, no falling scraps, favorable elasticity, no needle extracting leaked liquid, favorable sealing property and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical packaging materials, in particular to a synthetic polyisoprene rubber stopper for injection and a preparation method thereof. Background technique [0002] At present, in the field of rubber stoppers in pharmaceutical packaging materials, one of the rubber stoppers that need to directly contact drugs uses butyl rubber stoppers, that is, the main material in the rubber stopper formula --- rubber, which is halogenated butyl rubber; Another kind of rubber stopper that does not directly contact the drug uses a pharmaceutical synthetic polyisoprene gasket, that is, the main material in the formula-rubber, is isoprene rubber, specifically, the rubber gasket is combined with polypropylene It is used as a seal in the combination cap, and the polypropylene inner cap of the combination cap is in direct contact with the drug. [0003] The above two rubber plug materials have certain deficiencies and ...

Claims

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Application Information

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IPC IPC(8): C08L9/00C08K13/02C08K3/34C08K3/36C08K3/22C08K5/09C08K3/04C08K5/01B29C43/24B29C35/00B29B7/00A61M5/315
Inventor 肖维文闫宝英
Owner QINGDAO HUAREN MEDICAL PROD
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