Application of fresh euphorbia helioscopia juice in preparation of medicine for treating herpes simplex virus

The technology of herpes simplex virus and varnish is applied in the application field of preparing medicine for treating herpes simplex virus disease, and achieves the effects of low adverse reaction, small effective dose and strong anti-herpes simplex virus activity

Inactive Publication Date: 2012-10-10
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Purpose of the invention: the technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and through a large number of experimental screenings, research and development of fresh lacquer juice is used in the preparation of herpes simplex Application of drugs for viral diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of fresh euphorbia helioscopia juice in preparation of medicine for treating herpes simplex virus
  • Application of fresh euphorbia helioscopia juice in preparation of medicine for treating herpes simplex virus
  • Application of fresh euphorbia helioscopia juice in preparation of medicine for treating herpes simplex virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Xianze lacquer juice: take fresh lacquer, remove the roots, wash, mash the fresh stems, leaves and flowers, filter and squeeze the juice through gauze to obtain fresh juice containing fresh crude drug 18g / ml, filter and sterilize at -20°C Save it for later use.

Embodiment 2

[0023] Embodiment 2 Pharmacological experiment

[0024] 1 material

[0025] 1.1 Cell line Vero cells (African green monkey kidney cells) were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences, passaged and preserved in our laboratory.

[0026] 1.2 Drugs. Fresh lacquer juice prepared in Example 1 of the present invention, lacquer water decoction (the preparation method is: take the dried lacquer, add 10 times the amount of distilled water and decoct it to half the volume at 100°C, filter to obtain the filtrate, and concentrate to Extract, so that the crude drug content is 20mg / ml, stored at 4°C); the positive control drug is acyclovir (ACV), Hubei Qianjiang Pharmaceutical Co., Ltd., batch number 20040802.

[0027] 1.3 The main reagents are penicillin (Shandong Lukang), streptomycin sulfate (Amresco), MTT (thiazole salt, Genebase), trypsin (Nanjing Shengxing), EDTA (Sigma), RPMI-1640 medium (GIBCO), iodide Propidium (PI, Sigma, USA), RPMI-1640 (GIBCO), ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of fresh euphorbia helioscopia juice in the preparation of a medicine for resisting herpes simplex virus. A large number of experimental screening and experimental results prove that the fresh euphorbia helioscopia juice has a significant effect of inhibiting the cytopathic effect caused by the herpes simplex virus in vitro. The fresh euphorbia helioscopia juice has low toxicity and can lead to slight adverse reactions. The euphorbia helioscopia resources are wide and easy to obtain, have low cost and wide application prospect, can be developed sustainably and are expected to be developed into the medicine for resisting the herpes simplex virus.

Description

technical field [0001] The invention relates to a new application of fresh lacquer juice, in particular to the application of fresh lacquer juice for preparing medicine for treating herpes simplex virus disease. Background technique [0002] In recent years, with the aging of the social population, organ transplantation, the application of immunosuppressants and the increase of human immunodeficiency virus (HIV) infection, the immune function of patients has declined. Among them, the low immune function caused by HIV infection is the main cause of herpes simplex virus infection and recurrence, and herpes simplex virus acts as a cofactor to increase the possibility of HIV transmission, promote the onset of AIDS and affect the prognosis. Clinical investigations show that the recurrence of herpes virus Infection is the leading cause of death in immunocompromised persons. HSV-1 infection can cause cold sores, herpetic paronychia and other rashes such as traumatic herpes, herp...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P31/22
Inventor 张军峰董伟孟玉芬詹瑧何立巍马宏跃马肖兵
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap