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Vitamin B12 complex fermenting addition agent and application method thereof to fermenting vitamin B12

A technology of compound fermentation and application method, applied in the direction of microorganism-based method, biochemical equipment and method, fermentation, etc., to achieve the effect of ensuring supply, ensuring fermentation effect, and improving fermentation output

Active Publication Date: 2012-10-10
山东祥维斯生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The first technical problem to be solved by the present invention is: aiming at the deficiencies of the prior art, provide a strain respiration regulator used in fermentation, which can ensure the constant supply of various trace elements and reduce the Fermentation problems caused by unstable trace elements in the source, vitamin B that can effectively increase fermentation yield 12 Compound Fermentation Auxiliary
[0005] The second technical problem to be solved by the present invention is to provide a method that can ensure the constant supply of various trace elements and reduce the fermentation problems caused by the instability of trace elements in organic carbon and nitrogen sources, and can Vitamin B that effectively increases fermentation yield 12 Compound fermentation aids in vitamin B 12 Application methods in fermentation

Method used

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  • Vitamin B12 complex fermenting addition agent and application method thereof to fermenting vitamin B12
  • Vitamin B12 complex fermenting addition agent and application method thereof to fermenting vitamin B12

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Embodiment 1

[0022] Vitamin B 12 The compound fermentation aid is prepared by mixing the following raw materials by mass percentage: 95% anhydrous betaine, 0.55% compound vitamin and 4.45% compound amino acid; wherein the compound vitamin contains 45% by mass of thiamine, 10% pyridoxine hydrochloride and 45% folic acid; the compound amino acid contains 5% lysine, 15% serine, 15% glutamic acid, 35% asparagine and 30% aspartic acid acid. The content of residual amine in the betaine is 0.01wt%.

Embodiment 2

[0024] Vitamin B 12 The compound fermentation aid is prepared by mixing the following raw materials in mass percentage: 93% betaine hydrochloride, 0.5% compound vitamin and 6.5% compound amino acid; the compound vitamin contains 35% thiamine by mass , 15% pyridoxine hydrochloride and 50% folic acid; wherein the compound amino acid contains 10% lysine, 10% serine, 15% glutamic acid, 30% asparagine and 35% asparagine acid. The content of residual amine in the betaine is 0.001wt%.

Embodiment 3

[0026] Vitamin B 12 The compound fermentation aid is prepared by mixing the following raw materials by mass percentage: 96% phosphate betaine, 0.15% compound vitamin and 3.85% compound amino acid; wherein the compound vitamin contains 50% by mass of thiamine, 10% pyridoxine hydrochloride and 40% folic acid; the compound amino acid contains 5% lysine, 15% serine, 10% glutamic acid, 32% asparagine and 38% aspartic acid acid. The content of residual amines in the betaine is 0.05wt%.

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Abstract

The invention discloses a vitamin B12 complex fermenting addition agent and an application method thereof to fermenting vitamin B12. The vitamin B12 complex fermenting addition agent comprises the following components in percentage by mass of: 90-98% of betaine, 0.15-0.55% of vitamin B complex and 1.45-9.85% of complex amino acid, wherein the vitamin B complex comprises the following components in mass percentage: 30-55% of thiamine, 10-25% of pyridoxine hydrochloride and 40-55% of folic acid; and the complex amino acid comprises the following components in percentage by mass of: 5-10% of lysine, 10-15% of serine, 10-15% of glutamic acid, 30-35% of asparagine and 30-40% of aspartic acid. The complex fermenting addition agent disclosed by the invention is added into the fermented vitamin B12 so that the supply of various nutrient components in a fermentation process is ensured and the fermentation output of the vitamin B12 is effectively improved.

Description

technical field [0001] The present invention relates to vitamin B 12 The preparation of, specifically relates to a kind of for vitamin B 12 Composite fermentation aid in fermentation preparation and application method thereof. Background technique [0002] Vitamin B 12 It is a cobalamin compound, which is mainly used clinically to treat pernicious anemia, and is also used to treat various nervous system diseases and certain liver diseases. [0003] Vitamin B present 12 Mainly rely on Pseudomonas denitrification made by aerobic fermentation. The main components of the fermentation medium include organic carbon sources, organic nitrogen sources, betaine, a small amount of inorganic salts, and the like. Among them, the trace element nutritional factors attached to organic matter are indispensable factors for normal function and metabolic activities. As cofactors, they participate in the regulation of many microbial metabolisms and are a key link in the regulation of microb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/42C12R1/38
Inventor 马兴群吕丽娟吴宝强宋琦
Owner 山东祥维斯生物科技股份有限公司
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