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Loxoprofen-containing pharmaceutical composition

The technology of a pharmaceutical composition, loxoprofen sodium, is applied in the field of pharmaceutical compositions containing loxoprofen or its salts, which can solve the problems of preservation stability and other problems, and achieve inhibition of digestive tract damage, excellent preservation stability, The effect of excellent storage stability

Inactive Publication Date: 2012-10-17
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, it is still unknown whether there is an interaction between loxoprofen or its salt in the preparation and codeines that affects the storage stability of these compounds, etc.

Method used

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  • Loxoprofen-containing pharmaceutical composition
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  • Loxoprofen-containing pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] On the other hand, 68.1 g of loxoprofen sodium hydrate (manufactured by Daiwa Pharmaceutical Industry: trade name Japanese Pharmacopoeia loxoprofen sodium hydrate), 29.2 g of polyethylene glycol 6000 (manufactured by NOF, trade name polyethylene glycol 6000) were mixed. Alcohol 6000P), 24.3g of cornstarch (manufactured by Nichiden Chemical: trade name Cornstarch ST-C), and 8g of dihydrocodeine phosphate (manufactured by Shionogi Pharmaceutical: trade name of dihydrocodeine phosphate "SHIONOGI") , into a glass bottle (13K bottle), and stored at 50°C for 1 week (comparative example 1)

[0164] [Table 2]

[0165]

just after saving

1 day later

3 days later

1 week later

Comparative example 1

solidified white powder

solidified white powder

solidified white powder

solidified white powder

Example 1

white granular

white granular

white granular

white granular

[0166] As can be seen from Table 2, only ...

Embodiment 2

[0168] [Example 2] Preparation (2) in which loxoprofen sodium hydrate and dihydrocodeine phosphate do not substantially contact

[0169] In a glass beaker on a water bath at 65°C, 68.1 g of loxoprofen sodium hydrate (manufactured by Daiwa Pharmaceutical Industry: trade name Japanese Pharmacopoeia loxoprofen sodium hydrate), 29.2 g of polyethylene glycol 6000 (manufactured by NOF, Trade name polyethylene glycol 6000P) and 24.3 g of corn starch (manufactured by Nichiden Chemical Co., Ltd.: trade name Corn Starch ST-C), and then, after cooling, sieve through a No. 18 sieve to obtain a granulated product. 8 g of dihydrocodeine phosphate (manufactured by Shionogi Pharmaceutical Co., Ltd.: trade name dihydrocodeine phosphate "SHIONOGI"), 81 g of carboxymethylcellulose calcium (manufactured by Gotoku Pharmaceutical Co., Ltd., Product name ECG505), 591.3g of lactose (manufactured by DMV, product name lactose 200M) and 8.1g magnesium stearate (produced by Taiping Chemical Industry, pro...

Embodiment 3

[0170] [Example 3] Preparation (3) in which loxoprofen sodium and dihydrocodeine phosphate do not substantially contact

[0171] Tablets were obtained in the same manner except that polyethylene glycol 6000 was replaced with hardened oil (manufactured by Kawaken Fine Chemical: trade name K-3WAX-200).

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Abstract

Disclosed is a pharmaceutical composition containing loxoprofen or a salt thereof and codeine or the like, which has excellent storage stability. Specifically disclosed is a pharmaceutical composition which contains at least one component selected from the group consisting of codeine, carbinoxamine or a salt thereof, clemastine or a salt thereof, chlorpheniramine or a salt thereof, diphenylpyrraline or a salt thereof, bromhexine or a salt thereof, ambroxol or a salt thereof, lysozyme or a salt thereof and dextromethorphan or a salt thereof and loxoprofen or a salt thereof in such a manner that the at least one component and loxoprofen or a salt thereof are substantially not in contact with each other.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing loxoprofen or a salt thereof. Background technique [0002] Loxoprofen is a non-steroidal anti-inflammatory analgesic (NSAID), which is known to treat rheumatoid arthritis, osteoarthritis, low back pain, periarthritis of the shoulder, neck, shoulder and wrist syndrome, toothache, acute upper It is effective in anti-inflammatory, analgesic and antipyretic after respiratory tract inflammation, post-operation, trauma and tooth extraction (Non-Patent Document 1). [0003] Starting from its excellent pharmacological effects, the combination of loxoprofen and various drugs is being studied. As the action produced by the combination, for example, the enhancement action of the anti-inflammatory, analgesic, and antipyretic effects produced by the combination with caffeine, ethyl salicylamine, and acetaminophen (Patent Document 1); Improvement of nasal congestion symptoms by combination o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K9/14A61K9/16A61K9/20A61K9/48A61K31/137A61K31/192A61K31/4402A61K38/46A61P11/00A61P29/00
CPCA61K9/1617A61K31/4402A61K31/137A61K31/192A61K31/485A61K9/1652A61K9/1641A61K38/47A61K9/2077A61P1/02A61P11/00A61P11/02A61P11/04A61P11/10A61P11/16A61P19/02A61P21/00A61P25/04A61P29/00A61P43/00A61K2300/00A61K2121/00
Inventor 薄井俊树春原政明高宫雅哉
Owner KOWA CO LTD
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