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Use of perila seed extract with functions of protecting liver and lowering transaminase

A liver-protecting and enzyme-reducing technology, perilla seed technology, applied to medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve problems such as research is still in its infancy

Active Publication Date: 2012-10-24
哈尔滨美苏生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, due to its unique active substances and nutritional components, perilla has increasingly become a multi-purpose plant that has attracted much attention in the fields of medical care, food, and chemical industry at home and abroad. There are many studies on similar substances, but the research on perilla polysaccharides is still in its infancy. At present, there is no relevant research report that the extract of perilla seeds has the corresponding liver-protecting and enzyme-lowering effects.

Method used

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  • Use of perila seed extract with functions of protecting liver and lowering transaminase
  • Use of perila seed extract with functions of protecting liver and lowering transaminase
  • Use of perila seed extract with functions of protecting liver and lowering transaminase

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Effect test

specific Embodiment approach 1

[0012] Specific embodiment 1: The use of a perilla seed extract with liver-protecting and enzyme-lowering effects in the preparation of a drug for liver-protecting and enzyme-lowering according to this embodiment.

[0013] The perilla seed extract obtained in this embodiment has the effect of significantly reducing alanine aminotransferase (GPT / ALT) and aspartate aminotransferase (GOT / AST) in serum, and has hepatoprotective effect. In terms of reducing enzymes, the positive control group reduced the two enzyme activities of GPT and GOT by 65.67% and 48.46%, respectively. Compared with the positive control group of the same quality, the experimental group reduced the two enzyme activities of GPT and GOT by 73.22% and 48.17%, also has the enzyme-reducing ability of the silymarin suspension of the positive control group. In terms of liver protection, with the increase of the dose of the experimental group, the changes of the liver coefficient and spleen coefficient gradually decr...

specific Embodiment approach 2

[0014] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the preparation method of the perilla seed extract with the function of protecting the liver and reducing enzymes is carried out according to the following steps: 1. Take perilla seeds and crush them , after passing through a 20-mesh sieve, the Soxhlet extraction method is used to degrease the crushed perilla seed powder to obtain the degreased perilla seed powder; 2. to reflux the degreased perilla seed powder obtained in step 1, and extract the Centrifuge for 10 minutes at a speed of 4000r / min; 3. Add absolute ethanol to the supernatant obtained after centrifuging in step 2 until the final volume percentage of ethanol is 70%, and after standing for 24 hours, centrifuge at a speed of 4000r / min Centrifuge for 10min under the conditions of the above conditions, and collect the precipitate; add 20 times of ethanol solution with a volume percentage of 70% to the precipitate, let ...

specific Embodiment approach 3

[0015] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that: the Soxhlet extraction method described in step one refers to: using petroleum ether with a boiling range of 30°C to 60°C, at a temperature of 40°C Under certain conditions, Soxhlet extraction was performed for 4 hours, and the upper layer powder was collected to obtain perilla seed powder; wherein, the mass volume ratio of perilla seed powder to petroleum ether was 1 g: 4 mL. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a use of a perila seed extract with functions of protecting liver and lowering transaminase, relating to a use of the perila seed extract. The invention provides use of the perila seed extract with the functions of protecting liver and lowering transaminase. The method comprises the following steps of: crushing perila seeds, extracting and degreasing the perila seeds in a Soxhelt type, extracting the perial seeds by water and precipitating the perila seeds by alcohol, centrifuging, water bathing and evaporating water, freezing and drying the perila seeds to obtain the perila seed extract. A pharmacodynamics experiment on the perila seed extract shows that the perila seed extract has strong functions of protecting liver and lowering transaminase. Therefore, the perila seed extract disclosed by the invention is applied to the field of liver protection and prevention and treatment of liver diseases.

Description

technical field [0001] The present invention relates to the application of perilla seed extract. Background technique [0002] Perilla, also known as Eba, Chisu, Baisu, Fragrant Su, etc., scientific name Perillafrutescens L., is an annual herb of Lamiaceae. With a specific aroma, it is native to China, and now it is mainly distributed in India, Myanmar, China, Japan, North Korea, South Korea, Indonesia and Russia. According to medical clinical research, its stems, leaves and seeds can be used as medicine; stems and leaves have analgesic, sedative, and antipyretic effects, which can treat colds, relieve fish and crab poisoning, vomiting and abdominal pain, etc.: seeds (fruits) have antitussive, expectorant, calm Breathing and diverging mental dull effect. Perilla has health care functions such as anti-oxidation, anti-aging, lowering blood fat, lowering blood sugar, anti-allergic, anti-microbial, improving memory and improving visual function. It is a kind of medicinal and e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/535A61P1/16A61K131/00
Inventor 李冲伟宋福强李宏涛孟利程丽
Owner 哈尔滨美苏生物科技开发有限公司
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