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Glucose electrolyte effervescent tablets and preparation method thereof

A technology for electrolytes and effervescent tablets, which is applied to pharmaceutical formulations, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of low production cost, shortened production process, short production cycle, etc., and achieves low production cost and shortened production time. The effect of short production process and production cycle

Inactive Publication Date: 2012-10-31
SICHUAN BAILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method is easy to operate, shortens the production process, short production cycle, safe and easy to control, and low production cost. The tablet prepared by this method not only overcomes the deficiency of high osmotic pressure of oral rehydration salts in China, but also improves the taste, which can effectively prevent It is more suitable for children who refuse oral rehydration salts due to bad taste

Method used

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  • Glucose electrolyte effervescent tablets and preparation method thereof
  • Glucose electrolyte effervescent tablets and preparation method thereof
  • Glucose electrolyte effervescent tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: a kind of glucose electrolyte effervescent tablet, its prescription is as follows:

[0061] Anhydrous glucose 1620g

[0062] Sodium chloride 117g

[0063] Potassium chloride 186g

[0064] Anhydrous citrate 384g

[0065] Sodium bicarbonate 336g

[0066] Macrogol 6000 120g

[0067] Neohesperidin Dihydrochalcone 2g

[0068] Orange essence 10g

[0069] Poloxamer 30g

[0070]

[0071] Made into 1000 pieces

[0072] The preparation method is as follows:

[0073] (1) Take the above-mentioned anhydrous glucose, sodium chloride, potassium chloride, anhydrous citrate, and sodium bicarbonate and pulverize them through a 100-mesh sieve for subsequent use;

[0074] (2) Neohesperidin dihydrochalcone, orange essence, and poloxamer passed through a 100-mesh sieve for later use;

[0075] (3) Heat polyethylene glycol 6000 to 60-70°C to melt completely, add sodium bicarbonate and stir evenly, let cool to room temperature, crush through a 100-mesh sieve for later...

Embodiment 2

[0078] Embodiment 2: a kind of glucose electrolyte effervescent tablet, its prescription is as follows:

[0079] Anhydrous glucose 1620g

[0080] Sodium chloride 117g

[0081] Potassium chloride 186g

[0082] Anhydrous citrate 384g

[0083] Sodium bicarbonate 336g

[0084] Macrogol 6000 120g

[0085] Neohesperidin Dihydrochalcone 2g

[0086] Orange essence 10g

[0087] Poloxamer 30g

[0088]

[0089] Made into 1000 pieces

[0090] The preparation method is as follows:

[0091] (1) Take the above-mentioned anhydrous glucose, sodium chloride, potassium chloride, anhydrous citrate, and sodium bicarbonate and pulverize them through a 100-mesh sieve for subsequent use;

[0092] (2) Neohesperidin dihydrochalcone, orange essence, and poloxamer passed through a 100-mesh sieve for later use;

[0093] (3) Heat polyethylene glycol 6000 to 60-70°C to melt completely, add sodium bicarbonate and stir evenly, let cool to room temperature, crush through a 100-mesh sieve for later...

Embodiment 3

[0096] Embodiment 3: a kind of glucose electrolyte effervescent tablet, its prescription is as follows:

[0097] Anhydrous glucose 1620g

[0098] Sodium chloride 117g

[0099] Potassium chloride 186g

[0100] Anhydrous citrate 384g

[0101] Sodium bicarbonate 336g

[0102] Macrogol 6000 120g

[0103] Neohesperidin Dihydrochalcone 2g

[0104] Orange essence 10g

[0105] Poloxamer 30g

[0106]

[0107] Made into 1000 pieces

[0108] Preparation:

[0109] (1) Take the above-mentioned anhydrous glucose, sodium chloride, potassium chloride, anhydrous citrate, and sodium bicarbonate and pulverize them through a 100-mesh sieve for subsequent use;

[0110] (2) Neohesperidin dihydrochalcone, orange essence, and poloxamer passed through a 100-mesh sieve for later use;

[0111] (3) Heat polyethylene glycol 6000 to 60-70°C to melt completely, add sodium bicarbonate and stir evenly, let cool to room temperature, crush through a 100-mesh sieve for later use;

[0112] (4) Take ...

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PUM

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Abstract

The invention discloses glucose electrolyte effervescent tablets and a preparation method for the glucose electrolyte effervescent tablets. By adopting a polyethylene glycol coating technology, the method is easy and convenient to operate, shortens the production procedure, and is short in production period, safe, easy to control and low in production cost; and the prepared tablets overcome the defect of high osmotic pressure of the conventional oral rehydration salts, improve the taste, can effectively prevent a condition that the oral rehydration salts are rejected due to poor mouthfeel, and are suitable for children.

Description

technical field [0001] The invention belongs to the technical field of chemical pharmacy, and relates to a glucose electrolyte effervescent tablet and a preparation method thereof. Background technique [0002] Diarrhea is a common intestinal disease, usually caused by improper diet or weather changes. Once diarrhea occurs, the body loses the most fluids and electrolytes in the body. Due to insufficient absorption or excessive loss of water, the body can be dehydrated, accompanied by the loss of sodium, potassium and other electrolytes, resulting in listlessness or irritability, pale, dry, poor elasticity of the skin, and even cold limbs and blooming skin , Shock symptoms such as decreased urine output. Clinically, the treatment methods for diarrhea mainly include: (1) antibiotics plus intravenous drip, but the disadvantages of antibiotics for disease treatment are obvious; (2) intravenous rehydration, which brings treatment risks and also makes patients suffer from inject...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/46A61K47/34A61P3/12A61K31/194A61K31/7004A61K33/00
Inventor 王一茜杜书良廖彬
Owner SICHUAN BAILI PHARM CO LTD
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