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Method for extracting and separating vitamin E polyethylene glycol succinic acid monoester and diester

A technology for polyethylene glycol succinic acid and vitamins, which is applied in the field of separation of monoesters and diesters, can solve complex and unseen problems such as separation of vitamin E polyethylene glycol succinic acid mono- and di-esters, and achieve less consumption and convenience Recycling and reuse, the effect of broad application prospects

Active Publication Date: 2012-11-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity and particularity of the components of the TPGS system, there have been no reports on the separation of vitamin E polyethylene glycol succinic acid mono- or di-ethylene glycol succinate by extraction

Method used

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  • Method for extracting and separating vitamin E polyethylene glycol succinic acid monoester and diester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] TPGS1000 mixture (wherein the mass percent composition of monoester and diester is 68.3%, 31.4% respectively) and ethyl acetate is made into 20 g / liter raw material liquid, with ethylimidazole tetrafluoroborate ([EMIm] [BF 4 ])-water mixed solvent ([EMIm]BF 4 The mass percentage is 50%) as the extractant, with ethyl acetate as the detergent, the volume flow ratio of the extractant, detergent, and raw material liquid is 3: 2.7: 1, and fractionation extraction is carried out in a fractionation extraction device at 40°C . The fractional distillation extraction is divided into an extraction section and a washing section, the extraction section has two stages, and the washing section has three stages. The extractant enters the fractionation extraction system from the first stage of the extraction section, the raw material liquid enters the fractionation extraction system from the last stage of the extraction section, the detergent enters the fractionation extraction system...

Embodiment 2

[0038] TPGS400 mixture (wherein the mass percent composition of monoester and diester is respectively 70.4%, 29.4%) and butyl acetate is made into the stock solution of 0.5 g / liter, with N-hexylpyridinium bromide ionic liquid ([HPy] Br) is the extractant, butyl acetate is used as the detergent, the volume flow ratio of the extractant, detergent, and raw material liquid is 2:4.2:1, and the fractionation extraction is carried out in a fractionation extraction device at 20°C. The fractional distillation extraction is divided into an extraction section and a washing section, the extraction section has three stages, and the washing section has three stages. The extract rich in TPGS monoester flows out from the first stage of the washing section, and the raffinate rich in TPGS diester flows out from the first stage of the extraction section, and the extract and raffinate are collected; the extract and raffinate are The butyl acetate was removed by vacuum concentration, the ionic liq...

Embodiment 3

[0040] TPGS 2000 mixture (wherein the mass percentage composition of monoester and diester is respectively 55.1%, 44.6%) and n-butanol is made into 100 g / liter raw material liquid, with tributylammonium chloride ([HNBu 3 ]C1)-water mixed solvent ([HNBu 3 ]Cl mass percentage is 99%) as extractant, with n-butanol as detergent, the volume flow ratio of extractant, detergent, raw material liquid three is 13: 1.7: 1, carries out under 70 ℃ in fractional distillation extraction device Fractional distillation extraction. Fractional distillation extraction is divided into an extraction section and a washing section, the extraction section has two stages, and the washing section has two stages. The extract rich in TPGS monoester flows out from the first stage of the washing section, and the raffinate rich in TPGS diester flows out from the first stage of the extraction section, and the extract and raffinate are collected; the extract and raffinate are The n-butanol was removed by vac...

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PUM

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Abstract

The invention discloses a method for extracting and separating monoester and diester from a vitamin E polyethylene glycol succinic acid monoester and diester mixture. According to the method, water, hydrophilic ionic liquid, a binary mixed solvent consisting of the hydrophilic ionic liquid and the water, or a binary mixed solvent consisting of a completely water-soluble polar organic solvent and the water is taken as an extracting agent, an ester or alcohol hydrophobic organic solvent with the water solubility of more than or equal to 15g / 100g is taken as a washing agent, and the monoester and the diester are efficiently separated from the mixture containing the monoester and the diester by a fractional extraction method. The method has the advantages of high separation efficiency, low solvent consumption and the like, is safe and environment-friendly and is suitable for industrial production.

Description

technical field [0001] The invention relates to a chemical separation process, in particular to a method for separating monoesters and diesters from vitamin E polyethylene glycol succinic acid mono- and di-ester mixtures. Background technique [0002] Vitamin E polyethylene glycol succinate (d-alpha-tocopherol polyethylene glycol succinate, TPGS) is a water-soluble derivative of vitamin E, which is composed of vitamin E succinate and polyethylene glycol (PEG400~ PEG2000) esterification reaction. Since polyethylene glycol has two active hydroxyl groups, the esterification reaction will generate vitamin E polyethylene glycol succinic acid monoester and diester. The commonly mentioned TPGS refers to vitamin E polyethylene glycol succinate monoester. From the perspective of molecular structure, vitamin E polyethylene glycol succinate contains both the lipophilic tail of vitamin E and the hydrophilic head of polyethylene glycol, so it is an excellent non-ionic surfactant. Acco...

Claims

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Application Information

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IPC IPC(8): C08J3/00C08G65/48C07D311/72
CPCY02P20/54
Inventor 杨亦文孔利云邢华斌杨启炜苏宝根张治国任其龙
Owner ZHEJIANG UNIV
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