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Callicarpa nudiflora dispersible tablet and preparation method thereof

A technology of nude flower purple beads and dispersible tablets, which is applied in the field of traditional Chinese medicine tablets, can solve the problems of low bioavailability, low content of active ingredients, and complicated extraction steps, and achieve better extraction effects, high drug efficacy, and beneficial Dissolution effect

Inactive Publication Date: 2012-11-28
HUNAN WARRANT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a nude flower purple bead dispersible tablet and a preparation method thereof, so as to solve the problems in the prior art that the extraction steps are complicated, the active ingredient content is low, and the bioavailability is not high.

Method used

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  • Callicarpa nudiflora dispersible tablet and preparation method thereof
  • Callicarpa nudiflora dispersible tablet and preparation method thereof

Examples

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preparation example Construction

[0019] The invention provides a kind of preparation method of nude flower purple pearl dispersible tablet, comprises the following steps:

[0020] 1) Take the naked flower purple pearl and carry out the extraction step. The extraction step is to crush the naked flower purple pearl into a coarse powder and add an ethanol solution with a volume ratio of 1:3~7 to soak for 3 to 5 hours to obtain the initial extract. The primary extract is extracted by ultrasonic wave at room temperature for 10-15 minutes at a power of 300-500w to obtain the extract;

[0021] 2) Concentrate the extract, dry it, and obtain dry cream powder;

[0022] 3) Take 60~70wt% of the dry paste powder, add 20~30wt% filler, 2~5wt% disintegrant, 3~10wt% binder, mix well and grind into fine powder;

[0023] 4) performing a granulation step on the fine powder to obtain a soft material;

[0024] 5) The soft material is subjected to a tablet compression step to obtain nudehuazizhu dispersible tablets.

[0025] In ...

Embodiment 1~9

[0037] Grind the prescription amount of Auranthus nudiflora into coarse powder, weigh them, add ethanol solution with a volume ratio of 1:5, and extract according to the experimental conditions of Examples 1 to 9 shown in Table 1 to obtain the extract , Determination of the amount of total flavonoids, terpenoids, tannins contained in the extract in Examples 1 to 9. Wherein the terpenoids only need to be oleanolic acid and ursolic acid.

Embodiment 10

[0052] 1) Crush the purple pearl of nudibranchs into coarse powder and add ethanol solution with a volume ratio of 1:5 to soak for 4 hours to obtain the initial extract, and extract the initial extract by ultrasonic wave at room temperature with a power of 400w for 10 minutes to obtain the extract.

[0053] 2) Concentrate the extract, dry it, and obtain dry cream powder;

[0054] 3) Take 60wt% dry paste powder, add 28wt% filler, 2wt% disintegrant, 10wt% binder, mix well and grind into fine powder;

[0055] 4) Spray fine powder into diluent to make soft material; diluent is prepared by dissolving 0.005wt% surfactant in 60wt% ethanol solution.

[0056] 5) After adding 1wt% tableting auxiliary material and 4wt% disintegrant to the soft material, the nude flower purple pearl dispersible tablet is compressed.

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Abstract

The invention provides a callicarpa nudiflora dispersible tablet and a preparation method thereof. The preparation method comprises the following steps of: grinding callicarpa nudiflora into coarse powder, adding the coarse powder in an ethanol solution for soaking for 3-5 hours to obtain a primary extraction liquid, ultrasonically extracting the primary extraction liquid for 10-15 minutes under the power of 300-500w to obtain an extraction liquid, wherein the volume ratio of the coarse powder to the ethanol solution is 1:(3-7); concentrating and drying the extraction liquid to obtain dry paste powder; adding 20-30wt% of filling agent, 2-5wt% of disintegrating agent and 3-10wt% of adhesive to 60-70% of the dry paste powder, uniformly mixing and grinding into fine powder; pelletizing the fine powder to obtain a soft material; and tabletting the soft material to obtain the callicarpa nudiflora dispersible tablet. The callicarpa nudiflora dispersible tablet provided by the invention can be used for solving the problems of low content of active ingredients and poor bioavailability of the existing callicarpa nudiflora dispersible tablet.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine tablets, in particular to a nude flower dispersible tablet. In addition, the present invention also relates to a preparation method comprising the dispersible tablet of Auranthus nudiflora. Background technique [0002] Nadihuazizhu has the functions of detoxification, convergence and hemostasis, and is used to treat inflammation caused by bacterial infection, acute infectious hepatitis, gastrointestinal bleeding and other diseases. The dosage forms of nudihuazizhu include ordinary tablets and capsules, and have been included in the standards issued by the Ministry of Pharmaceuticals. The commercially available Nudehuazizhu Tablets have problems such as slow disintegration, slow dissolution, low solubility, which is not conducive to the rapid action of the drug, and low bioavailability; while the Nudehuazizhu Capsules are too large, making it difficult for children and the elderly to s...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/20A61P7/04A61P31/04A61P1/16A61P31/14A61P31/20
Inventor 周志刚肖利辉庞永清于跃丰
Owner HUNAN WARRANT PHARMA
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