A kind of preparation method of cefcapene hydrochloride

A technology for cefcapine hydrochloride and cefcapine axetil, which is applied in the field of preparing monohydrate hydrochloride, can solve problems such as industrial scale-up production, difficult handling, unstable materials, etc., and achieves reduction of long-term storage and high conversion rate , the effect of rapid response
CN102796117BActive Publication Date: 2016-08-10SHENZHEN SALUBRIS PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN SALUBRIS PHARMA CO LTD
Publication Date
2016-08-10

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Abstract

The invention relates to a method for preparing cefcapene pivoxil hydrochloride shown as a formula (I). By the method, the reaction time is shortened, the yield is improved, and the safety is high, so that the method is suitable for industrial production.
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Description

technical field

[0001] The invention relates to a preparation method for removing a Boc protecting group in the production process of cefcapene hydrochloride and a method for preparing monohydrate hydrochloride. Background technique

[0002] The chemical name of cefcapene pivoxil hydrochloride is 2,2-dimethylpropionyloxymethyl(6R,7R)-7-[(2Z)-2-(2-aminooxythiazol-4-yl)pentyl-2 -enoyloxy]-3-carbamoyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.4.0]oct-2-ene-2-carboxylate hydrochloride Monohydrate, its chemical structure is as shown in formula (I),

[0003]

[0004] Cefcapene pivoxil hydrochloride (Cefcapene pivoxil hydrochloride) is a third-generation cephalosporin antibiotic, which belongs to a broad-spectrum antibiotic. Pharmacological studies have shown that the MIC80 of MSSA against aerobic G+ bacteria is 3.13 μg / ml, and it is comparable to cefotiam and cefaclor Similarly, the MIC80 for Streptococcus pneumoniae is less than or equal to 0.1 μg / ml, which is better than cefaclo...

Claims

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