Method for preparing hydrogel microparticles based on paper chip technology
A technology of paper chips and microparticles, applied in chemical instruments and methods, colloid chemistry, colloid chemistry, etc.
Inactive Publication Date: 2012-12-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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[0005] The purpose of the present invention is to provide a method for preparing hydrogel microparticles based on paper chip technology to solve the problems of long preparation period and complicated operation in the prior art And other issues
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The invention provides a method for preparing hydrogel microparticles based on a paper chip technology. A paper chip consists of patterns which are sprayed and printed on paper by a wax spray printer, and is immersed in a solution containing calcium ions and alginate to form hemispheric alginate hydrogel microparticles with codes; and the formed hemispheric microparticles can be combined under a microscope to form asymmetrical spherical hydrogel microparticles. The asymmetrical microparticles can be applied to mutual effects among cells, the irritation influence of medicines on the cells and the like, and have an excellent application prospect on the study of the cells, the screening of the medicines and the like. The method is simple, easy to operate and low in cost, and the prepared microparticles have the advantages of uniform sizes, controllable sizes and the like.
Description
technical field [0001] The invention relates to a method for preparing hydrogel microparticles, and in particular provides a method for preparing hydrogel microparticles based on paper chip technology. Background technique [0002] Hydrogel is a water-soluble polymer with a cross-linked network structure. The network structure is soft in nature, can maintain a certain shape, and can absorb a certain amount of solvent. [0003] At present, the technologies used to synthesize hydrogel microparticles mainly include selective microemulsion polymerization, radiation precipitation polymerization, and irradiation of dilute polymer solutions. These technical methods can synthesize spherical or nearly spherical hydrogel microparticles, but the operation is complex and cumbersome, the particle size of the formed microspheres is not uniform, and the size of the prepared microparticles is also difficult to achieve precise control. [0004] At present, there have been research reports ...
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IPC IPC(8): B01J13/00
Inventor 黄术强秦建华林炳承姜雷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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