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Chitosan nanoparticles and their preparation method and use

A technology of chitosan nano and nano particles, which is applied in the field of medicine, can solve the problems of long period of nanoparticles, poor sustained release effect of nanoparticles, and need to react overnight, etc., and achieves short preparation cycle, mild conditions and biocompatibility good effect

Active Publication Date: 2015-01-21
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the slow-release effect of the nanoparticles is not good. At pH 6.8, about 60% of the drug is released within 24 hours; at the same time, the preparation period of the nanoparticles is relatively long, and it needs to be reacted overnight.

Method used

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  • Chitosan nanoparticles and their preparation method and use
  • Chitosan nanoparticles and their preparation method and use
  • Chitosan nanoparticles and their preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Take 0.2376 g of methacryloyl polyethylene glycol 400 butyric acid and 0.0888 g of chitosan with a viscosity average molecular weight of 50,000 and a degree of deacetylation of 90% in a four-necked bottle, and add 50 ml of deionized water. Heated to 70°C and stirred for 4h. Add 0.005 g of initiator potassium persulfate under the protection of nitrogen, and continue stirring at 70°C for 1.5h, the system appears opalescent, cool down to 60°C, and continue stirring for 2h. After the reaction is finished, remove the insolubles by filtering with filter paper, then put the nanoparticle solution into a dialysis bag with a molecular weight cut-off of 3500, and dialyze for 48 hours. The solution contained in the dialysis bag is the chitosan nanoparticle. The average particle size is about 193nm.

[0052] In the present embodiment, the infrared figure of the chitosan that the number average molecular weight is 50000 is as follows figure 1 As shown, the infrared image of the obt...

Embodiment 2

[0054] Take 0.2376 g of methacryloyl polyethylene glycol 400 butyric acid and 0.1 g of chitosan with a number average molecular weight of 5000 and a deacetylation degree of 90% in a four-necked bottle, and add 50 ml of deionized water. Heated to 70°C and stirred for 4h. Add 0.005 g of initiator potassium persulfate under the protection of nitrogen, continue stirring at 70°C for 1.5h, the system appears opalescent, cool down to 60°C, add 0.001g of glutaraldehyde, and continue stirring for 2h. After the reaction is finished, remove the insolubles by filtering with filter paper, then put the nanoparticle solution into a dialysis bag with a molecular weight cut-off of 3500, and dialyze for 48 hours. The solution contained in the dialysis bag is the chitosan nanoparticle. The average particle size is about 100nm.

[0055] In the present embodiment, the transmission electron microscope figure of the chitosan nanoparticle of gained is as follows Figure 5 shown.

Embodiment 3

[0057] Take 0.2376 g of acryloyl polyethylene glycol 400 butyric acid and 0.09 g of chitosan with a number average molecular weight of 300,000 and a degree of deacetylation of 85% in a four-necked bottle, and add 50 ml of deionized water. Heated to 70°C and stirred for 4h. Add 0.004 g of initiator ammonium persulfate under the protection of nitrogen, and continue to stir at 70°C for 1 hour, the system appears opalescent, cool down to 60°C, add 0.001g of ethylene glycol dimethacrylate, and continue to stir for 2 hours. After the reaction, remove larger polymers by filtration, put the nanoparticle solution into a dialysis bag with a molecular weight cut-off of 3500, and dialyze for 48 hours. The solution contained in the dialysis bag is the chitosan nanoparticle. The average particle size is about 181nm.

[0058] In the present embodiment, the particle size distribution figure of the chitosan nanoparticles of gained is as follows Figure 6 shown.

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Abstract

The invention discloses chitosan nanoparticles and their preparation method and use. The chitosan nanoparticles comprise 5 to 50wt% of chitosan and 95 to 50wt% of polymethacryloylpolyoxalic acid or polyacryloylpolyoxalic acid and have an average particle size of 100 to 300nm. The preparation method allows mild conditions and has simple processes. The chitosan nanoparticles obtained by the preparation method have good biocompatibility, can be used as drug carriers, and have performances of slow release of drugs and pH value-responsive release of drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a chitosan nano particle and a preparation method thereof, and is used as a drug carrier. Background technique [0002] In recent years, nanoparticle drug-loaded systems have been widely used in the field of biomedicine. There are various forms of nanoparticle drug-loading systems: such as nanoemulsions, nanomicelles, nanogels, nanocrystals, lipid nanoparticles, etc. The nanoparticle drug delivery system has the following advantages: (1) increase the water solubility of poorly soluble drugs and improve the dispersion; (2) slow and controlled release of drugs can be achieved after in vivo administration; (3) enhance drug targeting, Improve drug stability and reduce side effects. [0003] The key to the development of nanoparticle drug-loading system is the selection of materials for preparing nanoparticles. Among many materials for preparing nanoparticles, chitosan, as a natural pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/513A61K47/36A61K47/34A61P35/00
Inventor 邱飞张丹魏林刁勇
Owner HUAQIAO UNIVERSITY
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