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Traditional Chinese medicine preparation for preventing and treating aluminum-induced Alzheimer's disease and its production method

A technology for Alzheimer's disease and traditional Chinese medicine preparations, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as the lack of a very effective method for Alzheimer's disease.

Active Publication Date: 2015-10-07
广西百色清醒科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no very effective method for the treatment of Alzheimer's disease (AD). Some scholars have proposed a new strategy for the treatment of aluminum chelators. Therefore, finding new aluminum-expelling drugs has become an important topic of current research.

Method used

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  • Traditional Chinese medicine preparation for preventing and treating aluminum-induced Alzheimer's disease and its production method
  • Traditional Chinese medicine preparation for preventing and treating aluminum-induced Alzheimer's disease and its production method
  • Traditional Chinese medicine preparation for preventing and treating aluminum-induced Alzheimer's disease and its production method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Haier Fu oral liquid:

[0063] (1) Take 6g of poria cocos, 3g of licorice root, 3g of smilax cocos, 6g of coix seed, 2g of mung bean coat, and 5g of white fungus, add 5-8 times the amount of water to decoct twice, each time for 2-3 hours, and combine into liquid A;

[0064] (2) Concentrate the above medicinal liquid A by heating to obtain concentrated liquid B;

[0065] (3) After B is cooled, add 85-95% ethanol aqueous solution of 3 times the volume concentration, mix well, put it in a refrigerator or ice bank at 4°C to 8°C, let it stand for 16-24 hours, filter, and remove the precipitate;

[0066] (4) Ethanol is recovered from the filtrate, the above-mentioned filtrate is placed in an ethanol recovery device, the ethanol is recovered by heating, the medicinal solution after recovering the ethanol is heated and concentrated, and a small amount of residual ethanol is volatilized to obtain the medicinal solution C;

[0067] (5) Take liquid C, add an appropriate amount of...

Embodiment 2

[0069] Haierfu Granules:

[0070] (1) Take 7g of Poria cocos, 3g of Smilax cocos, 7g of coix seed, 3g of licorice, 3g of mung bean coat, and 6g of white fungus, add 5-8 times the amount of water, heat and boil for 2-3 hours, 2-3 hours each time, and combine into liquid A ;

[0071] (2) Concentrate the above medicinal liquid A by heating to obtain concentrated liquid B;

[0072] (3) After B is cooled, add 85-95% ethanol aqueous solution of 3 times the volume concentration, mix well, put it in a refrigerator or ice bank at 4°C to 8°C, let it stand for 16-24 hours, filter, and remove the precipitate;

[0073] (4) Ethanol is recovered from the filtrate, the above-mentioned filtrate is placed in an ethanol recovery device, the ethanol is recovered by heating, the medicinal solution after recovering the ethanol is heated and concentrated, and a small amount of residual ethanol is volatilized to obtain the medicinal solution C;

[0074] (5) Concentrate liquid C to obtain dry cream ...

Embodiment 3

[0077] Haierfu Capsules:

[0078] (1) Take 7g of Poria cocos, 3g of Smilax cocos, 7g of coix seed, 3g of licorice, 3g of mung bean coat, 6g of tremella, add 5-8 times the amount of water, heat and boil for 2-3 hours, and combine into liquid A;

[0079] (2) Concentrate the above medicinal liquid A by heating to obtain concentrated liquid B;

[0080] (3) After B is cooled, add 85-95% ethanol aqueous solution of 3 times the volume concentration, mix well, put it in a refrigerator or ice bank at 4°C to 8°C, let it stand for 16-24 hours, filter, and remove the precipitate;

[0081](4) Ethanol is recovered from the filtrate, the above-mentioned filtrate is placed in an ethanol recovery device, the ethanol is recovered by heating, the medicinal solution after recovering the ethanol is heated and concentrated, and a small amount of residual ethanol is volatilized to obtain the medicinal solution C;

[0082] (5) Concentrate liquid C and spray dry to obtain dry cream powder F;

[0083...

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Abstract

The invention discloses a traditional Chinese medicine preparation used for preventing and treating aluminum-induced senile dementia (AD). The medicine preparation is characterized in that the traditional Chinese medicine preparation is prepared from the raw materials of, by weight: 5-15 parts of tuckahoe, 3-6 parts of licorice root, 1-3 parts of glabrous greenbrier rhizome, 5-15 parts of ma-yuen jobstears seed, 5-10 parts of white tremella, and 1-3 parts of mung bean seed-coat. The medicine preparation has the functions of heat clearing, detoxifying, spleen strengthening, dampness eliminating, liver protecting, kidney protecting, blood circulation activating, stasis removing, and the like. With the medicine preparation, excretion of excessively accumulated aluminum in AD patient brains can be promoted; excessive harmful superoxide anion radicals such as O2 can be removed; brain cholinergic nerve system choline acetyltransferase (ChAT) activity, acetylcholinesterase (AchE) activity, and acetylcholine neurotransmitter content can be regulated; and patient memory and cognitive ability can be recovered and enhanced. The traditional Chinese medicine preparation is suitable to be used by AD patients in preventing and treating.

Description

technical field [0001] The invention relates to a medicine for preventing and treating aluminum-induced Alzheimer's disease (AD) and a production method thereof, in particular to a traditional Chinese medicine preparation for preventing and treating aluminum-induced Alzheimer's disease (AD) using traditional Chinese medicine as a raw material and a production method thereof , belonging to the field of traditional Chinese medicine. Background technique [0002] With the development of material civilization, people's living standards are getting higher and higher, and their life expectancy is getting longer and longer. Aging has become a living reality. The accompanying senile diseases, especially senile dementia, not only become a personal misfortune for the elderly, but also become a burden on the family and a burden on society. In developed countries, senile dementia has become the fourth cause of death. In my country, due to the accelerated aging process, the prevalence r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61P25/28
Inventor 张树球莫明鑫来光业
Owner 广西百色清醒科技有限公司
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