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Enrofloxacin effervescent granule for livestock and preparation method thereof

An effervescent granule, livestock and poultry technology, applied in the fields of pharmaceutical formula, drug delivery, antibacterial drugs, etc., can solve the problems of poor water solubility of enrofloxacin, unfavorable group drug administration, individual animal stress stimulation, etc., and achieve the goal of overcoming Slower release rate, improved bioavailability, increased effect of immediate release efficacy

Inactive Publication Date: 2013-01-09
GREAT BIOLOGY PHARMA TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, the dosage forms of enrofloxacin commonly used are mainly powder, injection and suspension. However, due to the poor water solubility and bitter taste of enrofloxacin itself, there are great restrictions on the way of administration to animals, and it is not conducive to the animal body. absorb
The powder is not convenient for animals to take orally; the injection has a short action time in the body, and it needs repeated injections and administration to the animals for many times, which causes strong stress stimulation to the individual animals, which is time-consuming and troublesome, and is not conducive to group administration; the above defects also exist in the suspension. Facilitate group drug administration and increase feeding costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An effervescent enrofloxacin granule for livestock and poultry, the raw materials, auxiliary materials and parts by weight are respectively:

[0024] Enrofloxacin: 100 parts; citric acid: 120 parts; sodium bicarbonate: 160 parts; polyethylene glycol 6000: 30 parts; dextrin: 230 parts; sucrose: 360 parts.

[0025] The preparation method of the above-mentioned enrofloxacin effervescent granules for livestock and poultry is:

[0026] (1) All the raw materials and auxiliary materials are pulverized to a particle size of 100 mesh and set aside;

[0027] (2) Take crushed enrofloxacin, citric acid, and polyethylene glycol 6000, dextrin, and sucrose that account for half of the total amount in parts by weight, and put the above-mentioned raw materials and auxiliary materials into a tank for mixing Machine mixing evenly, add purified water to make soft material, granulate, dry, and granulate;

[0028] (3) Weigh the crushed sodium bicarbonate, and the remaining polyethylene gly...

Embodiment 2

[0032] An effervescent enrofloxacin granule for livestock and poultry, the raw materials, auxiliary materials and parts by weight are respectively:

[0033] Enrofloxacin: 80 parts; citric acid: 120 parts; sodium bicarbonate: 160 parts; polyethylene glycol 6000: 40 parts; dextrin: 230 parts; sucrose: 370 parts.

[0034] The preparation method of the above-mentioned enrofloxacin effervescent granules for livestock and poultry is:

[0035] (1) All the raw materials and auxiliary materials are pulverized to a particle size of 100 mesh and set aside;

[0036] (2) Take crushed enrofloxacin, citric acid, and polyethylene glycol 6000, dextrin, and sucrose that account for half of the total amount in parts by weight, and put the above-mentioned raw materials and auxiliary materials into a tank for mixing Machine mixing evenly, add purified water to make soft material, granulate, dry, and granulate;

[0037] (3) Weigh the crushed sodium bicarbonate, and the remaining polyethylene glyc...

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PUM

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Abstract

The invention relates to an enrofloxacin effervescent granule for livestock and a preparation method of the enrofloxacin effervescent granule. The enrofloxacin effervescent granule comprises the following raw materials and auxiliary materials in parts by weight: 80-120 parts of enrofloxacin, 100-140 parts of citric acid, 150-170 parts of sodium bicarbonate, 20-40 parts of polyethylene glycol 6000, 190-260 parts of dextrin and 310-390 parts of cane sugar. The preparation method comprises the steps of respectively crushing the raw materials and the auxiliary materials, mixing, pelletizing, drying, granulating, and finally subpackaging. The enrofloxacin effervescent granule is developed according to veterinary drug GMP (Good Manufacturing Practice) standards by using modern detection means and pharmaceutical equipment, and is good in curative effect and is safe and reliable; the auxiliary materials and an effervescent disintegrating agent are added to the raw materials to prepare the effervescent granule; and the sick livestock administrates orally, the enrofloxacin effervescent granule is good in mouth feel and stable in quality, and the bioavailability of medicine is improved.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to an effervescent enrofloxacin granule for livestock and poultry and a preparation method thereof. Background technique [0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. The existing veterinary drug forms include tablets, oral liquids, injections, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are our future efforts in research and development of dosage forms. [0003] Enrofloxacin, also known as ethyl ciprofloxacin, is a third-generation fl...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/496A61K47/36A61P31/04
Inventor 王洪杰刘志辉苏永鹏黄健
Owner GREAT BIOLOGY PHARMA TIANJIN