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Neotame preparation method

A technology of neotame and aspartame, which is applied in the field of preparation of high-intensity sweetener neotame, which can solve the problems of unfavorable industrial production, expensive reducing agent, and high cost, and achieve the effects of quick response, low cost, and convenient operation

Inactive Publication Date: 2013-01-09
杭州浩博技术贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reducing agent used in it is expensive, high in cost, easy to absorb moisture, and difficult to operate, which is not conducive to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Add 300ml of methanol to a 500ml three-necked flask equipped with an electric stirrer and a condensing reflux device placed in a constant temperature water bath, start stirring, add 21.2g of aspartame, stir evenly, add 3,3- Dimethylbutyraldehyde 8.3g, 40°C, reacted for 15min; slowly added 2g of potassium borohydride, kept the temperature at 40°C, reacted for 50min; concentrated under reduced pressure to a thick slurry, added 120ml deionized water, 40°C, hydrolyzed for 1h. Use glacial acetic acid to adjust the pH to 5.5, let it stand to cool to room temperature, put it in the refrigerator (6-8°C) for 12 hours, crystallize, filter with suction, recrystallize the filter cake with methanol aqueous solution with a mass percentage concentration of 20%, and filter with suction , vacuum-dried at 40°C for 12 hours to obtain 19.57g of neotame, with a yield of 71.82%, and a purity of 98.88% by high performance liquid chromatography.

Embodiment 2

[0023] Example 2: The reaction device and operation method were the same as in Example 1, the difference being that the pH of the crystallization was adjusted to 6.5 to obtain 15.30 g of neotame with a yield of 56.15% and a purity of 99.25% by high performance liquid chromatography.

Embodiment 3

[0024] Example 3: The reaction device and operation method are the same as those in Example 1, the difference being that: ① first add 80ml of deionized water to the three-necked flask, preheat to 40°C, start stirring, add 21.2g of aspartame, and stir evenly; ② Add 8.5 g of 3,3-dimethylbutyraldehyde; ③ Add 3 g of potassium borohydride; the result is 20.46 g of neotame, with a yield of 75.08%, and a purity of 99.44% by HPLC.

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Abstract

The invention provides a neotame preparation method. The method includes: potassium borohydride is used as reducing agent for reducing reactant of aspartame and 3,3-dimethyl butyraldehyde to prepare neotame; condensing, hydrolyzing and crystallizing after reduction reaction; and using methanol or ethanol water for recrystallization to obtain neotame. The neotame preparation method is simplified in process, simple in equipment, convenient to operate, low in cost, quick in reaction, mild in condition, safe, environment-friendly and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of food additive preparation, in particular to a preparation method of neotame, a high-intensity sweetener. Background technique [0002] The chemical name of Neotame (Neutame, NTM) is N-[N-(3,3-dimethylbutyl)-L-α-asparagine]-L-phenylalanine 1-methyl ester, which is a dipeptide A derivative of the sweetener aspartame (Aspartame, APM, translated as aspartame); its performance is significantly better than that of aspartame, and it is a new type of dipeptide high-power sweetener. The structural formula is as follows: [0003] [0004] Neotame is a synthetic sweetener with the best safety, the highest sweetness, pure sweet taste, excellent stability and compound coordination, the lowest cost of use and the widest application range in the world so far. Neotame has particularly excellent performance, and its research and development and application are favored. According to a large number of animal experim...

Claims

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Application Information

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IPC IPC(8): C07K5/075C07K1/107
Inventor 陈锡连陈浩康恺
Owner 杭州浩博技术贸易有限公司
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