Antidotal capsule of Tibetan medicine compound and quality detection method of preparation of antidotal capsule

A quality inspection method and the technology of Jiedu capsules are applied in the direction of material analysis, measuring devices, instruments, etc. by observing the impact on chemical indicators, which can solve problems such as harm to human health, safety of preparations, acute iron poisoning, etc.

Active Publication Date: 2013-01-16
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive iron intake may cause acute iron poisoning and endanger human health.
[0004] The original quality standard of Jiedu Capsules only had bile acid thin-layer identification and gallic acid content determination items, and did not carry out quality control on the content of alkaloids and iron powder, the toxic components of Nuxebra chinensis, which made the preparation a potential safety hazard

Method used

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  • Antidotal capsule of Tibetan medicine compound and quality detection method of preparation of antidotal capsule
  • Antidotal capsule of Tibetan medicine compound and quality detection method of preparation of antidotal capsule
  • Antidotal capsule of Tibetan medicine compound and quality detection method of preparation of antidotal capsule

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0278] Embodiment 1: Jiedu capsule quality detection method

[0279] Jiedu Capsule includes bile acid TLC identification, gallic acid content measurement items (or not including these measurement items), and also includes the following measurement items:

[0280] A. Determination of Nuxychon content:

[0281] Determine according to high performance liquid chromatography (Appendix VID of "Chinese Pharmacopoeia" 2010 edition);

[0282] Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as filler; use acetonitrile-0.01mol / l sodium heptanesulfonate and 0.02mol / l potassium dihydrogen phosphate at a ratio of 20:80 by volume Equal volume mixed solution (adjust the pH value to 2.8 with 10% phosphoric acid by volume ratio) as the mobile phase; the detection wavelength is 260nm; the number of theoretical plates should not be less than 5000 based on the strychnine peak;

[0283] Preparation of reference substance solution: Take 6 mg of strychn...

Embodiment 2

[0304] Embodiment 2: Method for detecting the quality of detoxifying granules

[0305] Detoxification granules include bile acid thin-layer identification, gallic acid content measurement items (or not including these measurement items), and also include the following measurement items:

[0306] A. Determination of Nuxychon content:

[0307] Determine according to high performance liquid chromatography (Appendix VID of "Chinese Pharmacopoeia" 2010 edition);

[0308] Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as filler; use acetonitrile-0.01mol / l sodium heptanesulfonate and 0.02mol / l potassium dihydrogen phosphate at a ratio of 20:80 by volume Equal volume mixed solution (adjust the pH value to 2.8 with 10% phosphoric acid by volume ratio) as the mobile phase; the detection wavelength is 260nm; the number of theoretical plates should not be less than 5000 based on the strychnine peak;

[0309] Preparation of reference substan...

Embodiment 3

[0331] Embodiment 3: Jiedu pill quality detection method

[0332] Jiedu pills include bile acid thin-layer identification, gallic acid content measurement items (or may not include these measurement items), and also include the following measurement items:

[0333] A. Determination of Nuxychon content:

[0334] Determine according to high performance liquid chromatography (Appendix VID of "Chinese Pharmacopoeia" 2010 edition);

[0335] Chromatographic conditions and system suitability test: use octadecylsilane bonded silica gel as filler; use acetonitrile-0.01mol / l sodium heptanesulfonate and 0.02mol / l potassium dihydrogen phosphate at a ratio of 20:80 by volume Equal volume mixed solution (adjust the pH value to 2.8 with 10% phosphoric acid by volume ratio) as the mobile phase; the detection wavelength is 260nm; the number of theoretical plates should not be less than 5000 based on the strychnine peak;

[0336] Preparation of reference substance solution: Take 6 mg of stryc...

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Abstract

The invention discloses an antidotal capsule of a Tibetan medicine compound and a quality detection method of a preparation of the antidotal capsule. Content of strychnine of semen strychni is controlled by a high performance liquid chromatography (HPLC) process; iron content in iron powder is controlled by means of titration; cholic acid in calculus bovis artifactus and hydroxy saffionin A in safflower are detected quantitatively by the high performance liquid liquid-phase chromatography; so that efficacy is guaranteed while hidden dangers to health of patients when the patients take excessive antidotal capsules are avoided, and product quality is improved, product safety, stability and quality controllability are guaranteed.

Description

technical field [0001] The invention relates to a quality detection method of a Tibetan medicine composition preparation, in particular to a quality detection method of a Tibetan medicine composition Jiedu capsule and a preparation thereof. Background technique [0002] Jiedu Capsules originated from the Tibetan medical classics "Nanluku", which is a good prescription for Tibetan medicine to treat various poisoning diseases. It is recorded in the national standard part of the local standard of Chinese patent medicine, standard number: WS-10537 (ZD-0537)-2002. Jiedu Capsules are composed of 35 herbs such as nuxychonna (manufactured), safflower, iron powder (manufactured), artificial bezoar, pokeweed, dried pine, grass fruit, and pterygium. effect. For various toxic diseases, old fever, some contact dermatitis, etc. [0003] Jiedu Capsules contain toxic medicinal materials like nuxychia, and its toxic ingredients are mainly alkaloids, which have the effects of dredging coll...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N21/78
Inventor 马振元陈芹利任松鹏王海苹董玉波
Owner JINHE TIBETAN MEDICINE
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