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Application of felbinac tromethamine salt to preparation of medicine for treating eye inflammatory reactions

A felbinac tromethamine, inflammatory reaction technology, applied in the directions of drug combination, drug delivery, antipyretics, etc., can solve the problems of inability to prepare eye drops, strong eye irritation, strong irritation, etc.

Inactive Publication Date: 2013-01-23
GUANGDONG ZHONGKE DRUG R&D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most non-steroidal anti-inflammatory drugs cannot be prepared into eye drops for the treatment of eye inflammation due to their water solubility and irritation. Sometimes even if their water solubility is solved, they still have strong irritation. During the experiment, we found that although ibuprofen and arginine can be formulated into injections, they are still highly irritating to the eyes and cannot be prepared into eye drops

Method used

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  • Application of felbinac tromethamine salt to preparation of medicine for treating eye inflammatory reactions
  • Application of felbinac tromethamine salt to preparation of medicine for treating eye inflammatory reactions
  • Application of felbinac tromethamine salt to preparation of medicine for treating eye inflammatory reactions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1: the preparation of felbinac trometamol eye drops of different concentrations

[0009] Weigh 0.4g, 0.8g, 1.6g, 3.2g, 4.8g, 9.6g of felbinac tromethamine salt, add them to 1000ml of water for injection, stir for 5-10 minutes, adjust the pH value with sodium carbonate Between 7 and 8, filter and sterilize, fill into a 5ml plastic bottle for eye drops after washing and drying, seal and pack.

Embodiment 2

[0010] Example 2: Experimental study on the influence of felbinac tromethamine series eye drops of different concentrations on conjunctivitis in guinea pigs

[0011] experiment method:

[0012] There were 120 guinea pigs. Except for the vehicle control group (10 rats), the other groups prepared animal models of allergic conjunctivitis according to the method reported in the literature. ①Sensitization: Each guinea pig was given intraperitoneal injection of OVA (ovalbumin) suspension (OVA 0.1mg and AL(OH) 3 5 mg, dissolved in 1 mL of normal saline), and at the same time inject 1 ml of normal saline into the vehicle control group, and inject again after 14 days. ②Model evaluation and grouping: On the 7th day after the intraperitoneal injection, a passive skin immune response (PCA) test was performed, and it was determined that the OVA-IgE antibody titer increased to establish a successful model. Randomly select 80 successfully modeled animals and divide them into model groups, ...

Embodiment 3

[0030] Embodiment 3: Felbinac tromethamine eye drops New Zealand rabbit eye irritation test research method:

[0031] (1) Test method:

[0032] a) 6 animals that passed the quarantine inspection and passed the binocular examination with 0.5% fluorescein sodium and a slit lamp microscope (no eye irritation symptoms, corneal defects and conjunctival damage) were selected for the special research of this experiment. The test was carried out 1 hour after sodium fluorescein staining. Using the self-contrast method of the left and right eyes of the same body, give 2 drops of 0.5% felbinac tromethamine eye drops (each drop volume is about 50uL, and the volume of each administration is 100uL) on the left side, so that the rabbit's eyelids are passively closed. About 10 seconds; give an equal volume of 0.9% sodium chloride injection on the right side. The order of administration is the left side first and then the right side.

[0033] b) Fluorescein sodium examination method: pull d...

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Abstract

The invention discloses a medicine for treating conjunctivitis. The medicine consists of main ingredients of felbinac tromethamine salt, water, and sodium carbonate or sodium hydroxide for adjusting a PH value. Pharmacology experiments prove that eye drops prepared from the medicine can treat conjunctivitis, is good in tolerance and can be used for clinically treating eye inflammatory reactions such as conjunctivitis.

Description

Technical field: [0001] The invention relates to an eye drop for treating eye inflammation, which is composed of felbinac tromethamine, water, a pH regulator or felbinac, tromethamine, water, pH value modifier composition. Background technique: [0002] Allergic conjunctivitis is one of the most common immune eye diseases. According to statistics, more than 5% of people in the world seek medical treatment due to allergic eye diseases, and the proportion of allergic conjunctivitis exceeds 50%. In recent years, due to the use of eye cosmetics and the aggravation of air pollution in some areas, its incidence has further increased, so it is of great significance to study the treatment of allergic conjunctivitis. [0003] Antipyretic and analgesic drugs have been used by humans for more than 150 years. Now, antipyretic and analgesic drugs have become an indispensable and important drug in people's daily life. They are one of the most widely used and most widely used medicines in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K31/133A61P27/02A61P29/00
CPCA61K31/192A61K9/08A61K9/0048A61P27/02A61P29/00
Inventor 王伟王茜莎刘亚楠
Owner GUANGDONG ZHONGKE DRUG R&D