Method for extracting valerenic acid from valeriana fauriei

Abstract

The invention relates to a method for extracting valerenic acid from valeriana fauriei. The method comprises the following steps of: selecting valeriana fauriei and crushing the valeriana fauriei, passing the crushed valeriana fauriei through a 10-mesh sieve to obtain at least 70% of valeriana fauriei particles passing through the 10-mesh sieve; adding methanol solution, weight of which is 8-10 times that of the valeriana fauriei particles, to the valeriana fauriei particles, and reflowing and extracting the mixture to obtain valeriana fauriei extracting liquid; decompressing and concentrating the valeriana fauriei extracting liquid under a vacuum environment of 50-60 DEG C until no alcohol smell exists to obtain valeriana fauriei extract; adding hot water of 70 DEG C to 100 DEG C to the valeriana fauriei extract until the valeriana fauriei extract is dissolved to a valeriana fauriei mixed solution with mass fraction of 20%-24%; adding impurity-removing agent to the valeriana fauriei mixed solution, and filtering the mixture to obtain the valeriana fauriei filtrate; carrying out chromatography refining to the valeriana fauriei filtrate to obtain eluent containing valerenic acid; and concentrating and drying the eluent containing valerenic acid to obtain valerenic acid powder of the finished product. The embodiment of the invention not only increases effective output for obtaining valerenic acid from the valeriana fauriei and improves the purity of the valerenic acid, but also saves the production cost. The method is environment-friendly and pollution free, high in economic benefit, and very suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of biochemistry, in particular to a method for extracting valerenic acid from Valeriana broadleaf. Background technique [0002] Valerian is a traditional Chinese medicinal material in my country, and its active ingredients mainly include volatile oils, iridoids, flavonoids, alkaloids, etc. Valerenic acid is a sesquiterpene component isolated from the volatile oil of Valeriana genus; clinical trials have shown that valerenic acid has sedative and anti-anxiety effects, and is less drug-dependent and less addictive, so valerenic Oxalenoic acid has great potential in the development of safe, low toxicity and effective sedative-hypnotics and anxiolytics. [0003] At present, there are two methods for extracting valerenic acid from valerian in the prior art: [0004] The first method: use a certain concentration of ethanol to extract, but because ethanol has good solubility to many substances, many unnecessary ...

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Problems solved by technology

[0004] The first method: use a certain concentration of ethanol to extract, but because ethanol has good solubility to many substances, many unnecessary impurities will be brought in during the process of extracting valerenic acid; these impurities not only reduce It reduces the purity of valerenic acid, and brings a great burden to the subsequent separation and purification process, which increases the cost of the whole valerenic acid extraction process

[0005] The second method: adopt supercritical carbon dioxide device, and obtain valerian extract by high-speed countercurrent method, but this kind of equipment is very expensive and greatly increases the production cost, so it is rarely used in actual production

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