Method for extracting valerenic acid from valeriana fauriei

A technology of valerenic acid and valerian, applied in the field of biochemistry, can solve the problems of expensive equipment, rarely used, increased production costs, etc., to achieve the effects of improving production safety, increasing effective output, and saving production costs

Inactive Publication Date: 2014-12-10
贵州苗药生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The first method: use a certain concentration of ethanol to extract, but because ethanol has good solubility to many substances, many unnecessary impurities will be brought in during the process of extracting valerenic acid; these impurities not only reduce It reduces the purity of valerenic acid, and brings a great burden to the subsequent separation and purification process, which increases the cost of the whole valerenic acid extraction process
[0005] The second method: adopt supercritical carbon dioxide device, and obtain valerian extract by high-speed countercurrent method, but this kind of equipment is very expensive and greatly increases the production cost, so it is rarely used in actual production

Method used

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  • Method for extracting valerenic acid from valeriana fauriei
  • Method for extracting valerenic acid from valeriana fauriei
  • Method for extracting valerenic acid from valeriana fauriei

Examples

Experimental program
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Effect test

Embodiment 1

[0064] In this embodiment, weight is in kilograms (kg), and concentration is percentage by weight (%); figure 1 Shown, a kind of method extracting valerenic acid from Valerian officinale, its specific steps can comprise:

[0065] A, raw material crushing: choose 250kg of Valerian officinalis broadleaves to pulverize, and cross 10 mesh sieves, obtain at least 70% of Valerian officinale granules crossing 10 mesh sieves.

[0066] B, reflux extraction: add 2500kg of methanol solution to valerian granules, and reflux extraction at a heating temperature of 80 to 85°C for 2 hours, filter to obtain the first extracted filter residue and filtrate; add 2000kg of valerian to the first extracted filter residue Methanol solution, and reflux extraction at a heating temperature of 80-85°C for 1.5 hours, and filtered to obtain the filter residue and filtrate extracted again; the filtrates extracted twice were mixed together to obtain the valerian ethanol extract.

[0067] C. Concentration un...

Embodiment 2

[0074] In this embodiment, the weight is in kilograms (kg), and the concentration is weight percent (%); the difference between this embodiment and embodiment one is that the component content of the macroporous resin has been adjusted; the macroporous resin in this embodiment The porous resin is prepared by mixing the following raw materials in parts by weight: 20 parts of activated carbon, 30 parts of aluminum oxide and 50 parts of polyamide.

[0075] Under the situation that other processes are all the same as in Example 1, finally obtain the valerenic acid powder of 0.9075kg finished product.

[0076] After testing, the content of valerenic acid in the finally obtained valerenic acid powder was more than 8%, and the yield was 0.363%. It can be seen that the method for extracting valerenic acid from Valerian officinalis provided by the embodiments of the present invention improves the effective yield of valerenic acid from Valerian officinalis and improves the purity of val...

Embodiment 3

[0078] In this embodiment, the weight is in kilograms (kg), and the concentration is weight percent (%); the difference between this embodiment and embodiment one is that the component content of the macroporous resin has been adjusted; the macroporous resin in this embodiment The porous resin is prepared by mixing the following raw materials in parts by weight: 10 parts of activated carbon, 20 parts of aluminum oxide and 70 parts of polyamide.

[0079] Under the situation that other processes are all the same as in Example 1, finally obtain the valerenic acid powder of 0.9301kg finished product.

[0080] After testing, the content of valerenic acid in the finally obtained valerenic acid powder was more than 8%, and the yield was 0.372%. It can be seen that the method for extracting valerenic acid from Valerian officinalis provided by the embodiments of the present invention improves the effective yield of valerenic acid from Valerian officinalis and improves the purity of val...

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Abstract

The invention relates to a method for extracting valerenic acid from valeriana fauriei. The method comprises the following steps of: selecting valeriana fauriei and crushing the valeriana fauriei, passing the crushed valeriana fauriei through a 10-mesh sieve to obtain at least 70% of valeriana fauriei particles passing through the 10-mesh sieve; adding methanol solution, weight of which is 8-10 times that of the valeriana fauriei particles, to the valeriana fauriei particles, and reflowing and extracting the mixture to obtain valeriana fauriei extracting liquid; decompressing and concentrating the valeriana fauriei extracting liquid under a vacuum environment of 50-60 DEG C until no alcohol smell exists to obtain valeriana fauriei extract; adding hot water of 70 DEG C to 100 DEG C to the valeriana fauriei extract until the valeriana fauriei extract is dissolved to a valeriana fauriei mixed solution with mass fraction of 20%-24%; adding impurity-removing agent to the valeriana fauriei mixed solution, and filtering the mixture to obtain the valeriana fauriei filtrate; carrying out chromatography refining to the valeriana fauriei filtrate to obtain eluent containing valerenic acid; and concentrating and drying the eluent containing valerenic acid to obtain valerenic acid powder of the finished product. The embodiment of the invention not only increases effective output for obtaining valerenic acid from the valeriana fauriei and improves the purity of the valerenic acid, but also saves the production cost. The method is environment-friendly and pollution free, high in economic benefit, and very suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of biochemistry, in particular to a method for extracting valerenic acid from Valeriana broadleaf. Background technique [0002] Valerian is a traditional Chinese medicinal material in my country, and its active ingredients mainly include volatile oils, iridoids, flavonoids, alkaloids, etc. Valerenic acid is a sesquiterpene component isolated from the volatile oil of Valeriana genus; clinical trials have shown that valerenic acid has sedative and anti-anxiety effects, and is less drug-dependent and less addictive, so valerenic Oxalenoic acid has great potential in the development of safe, low toxicity and effective sedative-hypnotics and anxiolytics. [0003] At present, there are two methods for extracting valerenic acid from valerian in the prior art: [0004] The first method: use a certain concentration of ethanol to extract, but because ethanol has good solubility to many substances, many unnecessary ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P25/20A61P25/22
Inventor 何莉路贵霖吴琼明田浩
Owner 贵州苗药生物技术有限公司
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