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Carbomer gel and preparation method thereof

A carbomer gel and formulation technology, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, drug delivery, etc., can solve the problem of short residence time at the administration site, unhygienic and inconvenient medication, and poor drug absorption effect, etc. problem, achieve the effect of avoiding secondary cross-infection, rapid action, and fast drug release

Inactive Publication Date: 2013-03-27
娄飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional treatment of hemorrhoids has a short retention time at the administration site, resulting in poor absorption of the drug, affecting the efficacy of the drug, and the medication is unhygienic and inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Weigh 40g of carbomer, add 500g of water for injection to soak and swell, and let stand for 12h. While stirring, 50 g of triethanolamine solution was added to adjust the pH to 7.5 to form a transparent hydrogel.

[0019] 2. Weigh 300 g of glycerin, 0.1 g of disodium edetate, and 5 g of benzyl alcohol into the transparent hydrogel for emulsification and stirring for 1 hour.

[0020] 3. Add 104.9g of water for injection and continue stirring for 20 minutes to make the solution uniform.

[0021] 4. Sampling is carried out for intermediate inspection, and filling is carried out in a 10,000-level environment after passing the test.

[0022] 5. Packing and sealing after filling.

[0023] 6. Carry out microwave sterilization and packaging after bagging.

Embodiment 2

[0025] 1. Weigh 45g of carbomer, add 500g of water for injection to soak and swell, and let stand for 12 hours. While stirring, 45 g of ethylenediamine solution was added to adjust the pH to 7.0 to form a transparent hydrogel.

[0026] 2. Weigh 300 g of glycerol, 0.1 g of disodium edetate, and 5 g of benzoic acid into the transparent hydrogel for emulsification and stirring for 1 hour.

[0027] 3. Add 104.9g of water for injection and continue stirring for 20 minutes to make the solution uniform.

[0028] 4. Sampling is carried out for intermediate inspection, and filling is carried out in a 10,000-level environment after passing the test.

[0029] 5. Packing and sealing after filling.

[0030] 6. Carry out microwave sterilization and packaging after bagging.

Embodiment 3

[0032] 1. Weigh 50g of carbomer, add 500g of water for injection to soak and swell, and let stand for 12h. While stirring, 40 g of sodium hydroxide solution was added to adjust the pH to 6.5 to form a transparent hydrogel.

[0033] 2. Weigh 300g of glycerin, 0.1g of sodium sulfite, and 8g of sodium benzoate into the transparent hydrogel for emulsification and stirring for 1 hour.

[0034] 3. Add 101.9g of water for injection and continue to stir for 20 minutes to make the solution uniform.

[0035] 4. Sampling is carried out for intermediate inspection, and filling is carried out in a 10,000-level environment after passing the test.

[0036] 5. Packing and sealing after filling.

[0037] 6. Carry out microwave sterilization and packaging after bagging.

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PUM

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Abstract

The invention discloses carbomer gel and a preparation method thereof, relates to a medicament for treating hemorrhoids and the preparation method thereof and specifically relates to the carbomer gel and the preparation method thereof. The invention provides the carbomer gel with good efficacy and convenience in use and the preparation method thereof. The carbomer gel comprises the following components in percentage by weight (accounted by 100%): 3%-5% of carbomer, 3%-5% of triethanolamine, ethylenediamine or sodium hydroxide, 25%-35% of glycerol or propylene glycol, 0.5%-1% of benzyl alcohol, benzoic acid or sodium benzoate, 0.01-0.02% of ethylenediaminetetraacetic acid disodium or sodium sulfite and the balance of water.

Description

Technical field: [0001] The invention relates to a hemorrhoid drug and a preparation method thereof, more specifically, relates to a carbomer gel and a preparation method thereof. Background technique: [0002] The soft vein group formed by the expansion and flexion of the venous plexus under the mucous membrane of the end of the human rectum and the skin of the anal canal is called hemorrhoids, also known as hemorrhoids, hemorrhoids, hemorrhoids, hemorrhoids, etc. Hemorrhoids referred to in medicine include internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids. It is a chronic disease of one or more soft veins formed by varicose veins at the bottom of the anus and rectum and the anal mucosa. [0003] According to relevant census data, the incidence rate of anorectal diseases is 59.1%, and hemorrhoids account for 87.25% of all anorectal diseases, and among them, internal hemorrhoids are the most common, accounting for 52.19% of all anorectal diseases. Both men a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61P9/14
Inventor 娄飞
Owner 娄飞
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