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Preparation and application of carbon nano tube-containing thermo-sensitive type gel entrapping for indissolvable drug

A technology of insoluble drugs and carbon nanotubes, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, which can solve the problem of low encapsulation efficiency and drug loading, and critical micelle concentration. High, low stability and other issues, to achieve the effect of improving bioavailability, improving bioavailability, and improving stability

Inactive Publication Date: 2013-04-03
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, poloxamers have low encapsulation efficiency and drug loading capacity, high critical micelle concentration, and low stability, which limit their applications.

Method used

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  • Preparation and application of carbon nano tube-containing thermo-sensitive type gel entrapping for indissolvable drug
  • Preparation and application of carbon nano tube-containing thermo-sensitive type gel entrapping for indissolvable drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] Preparation and anti-tumor activity of carbon nanotube thermosensitive gel containing paclitaxel.

[0028] 1. Preparation:

[0029] (1) Prepare 100 mL of a poloxamer solution with a volume ratio of 18% and 100 mL of a chitosan solution with a volume ratio of 0.8%, mix the two solutions, and continue to magnetically stir for 30 minutes to obtain poloxamer / chitosan Temperature sensitive gel;

[0030] (2) After mixing 0.01 g of carbon nanotubes with 20 mL of the poloxamer / chitosan temperature-sensitive gel obtained in step (1), high-speed shearing at 4000 r / min for 20 minutes, to obtain a pore containing carbon nanotubes Loxamer / chitosan temperature-sensitive gel;

[0031] (3) Dissolve 10 mg of paclitaxel in absolute ethanol, mix with the gel obtained in step (2), subject it to 3000r / min high-speed shearing for 20 minutes, freeze-dry to obtain a particle size of 400-600nm containing paclitaxel Temperature-sensitive gel nanoparticles containing carbon nanotubes.

[0032] 2. Anti-...

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Abstract

The invention discloses preparation and application of carbon nano tube-containing thermo-sensitive type gel entrapping for an indissolvable drug. The preparation method comprises the steps of: 1, preparing a poloxamer solution with a volume ratio of 10-40 percent and a chitosan solution with a volume ratio of 0.1-1 percent, mixing the two solutions in a volume ratio of 1:1 to obtain poloxamer / chitosan thermo-sensitive type gel; 2, mixing 0.01-0.1g of carbon nano tube with 20mL of poloxamer / chitosan thermo-sensitive type gel obtained in the step 1, carrying out high-speed shearing to obtain carbon nano tube-containing poloxamer / chitosan thermo-sensitive type gel; and 3, after dissolving the indissolvable drug in a treatment effective dose in a solvent and mixing with the carbon nano tube-containing poloxamer / chitosan thermo-sensitive type gel obtained in the step 1, shearing at a 2000-5000r / min, freeze-drying to obtain nano particles with particle sizes of 400-600nm. The preparation method has the advantages of simpleness in operation, developed process and high yield; and the prepared thermo-sensitive gel is low in critical micelle concentration, is strong in adhering force with focus tissues, high in drug loading capacity, long in drug sustained release time and high in drug effective utilization rate, and is applied to oral administration and injection administration.

Description

Technical field [0001] The invention relates to a method for preparing a novel temperature-sensitive carbon nanotube-containing gel for poorly soluble drugs and its application in oral and injection administration, belonging to the field of pharmaceutical preparations. Background technique [0002] At present, many of the anti-cancer active compounds are polycyclic compounds, such as camptothecin, paclitaxel, tamoxifen, methotrexate, 5-fluorouracil, etc., and they all have a common characteristic, that is, they are difficult to dissolve in water. Or slightly soluble in water. In order to effectively use these drugs while reducing their toxicity to normal tissue cells, researchers in the field of pharmaceutical preparations implanted them into polymers, which made use of the stable properties, good biocompatibility, and strong solubilization ability of the polymers. Etc. Among the many types of polymers, polysaccharides with excellent biocompatibility and biodegradability have a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/34A61K47/02A61K45/00
Inventor 欧俊王芳江玉民
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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