PH-responded micro-fluid self-driven micro-fluidic chip and preparation method thereof

A microfluidic chip and microfluidic technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve problems such as no substantial breakthroughs, achieve good application prospects, reduce costs, Simple operation effect

Inactive Publication Date: 2013-04-17
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it is difficult for conventional technologies to intelligently drive microfluids in microchannels. Therefore, it is necessary to develop a convenient, fast, and High-efficiency and low-cost microfluidic drive technology should be one of the research directions on how to control microfluidics on microfluidic chips, and there has been no substantial breakthrough yet

Method used

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  • PH-responded micro-fluid self-driven micro-fluidic chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to form a smart micropump based on a microfluidic chip. The sample solution is added to the injection hole of the microfluidic chip, and the solution enters the microchannel driven by an external peristaltic pump. In the micropump area of ​​the microchannel,...

Embodiment 2

[0024] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to form a smart micropump based on a microfluidic chip. The sample solution is added to the injection hole of the microfluidic chip, and the solution enters the microchannel driven by an external peristaltic pump. In the micropump area of ​​the microchannel, the surface responds ...

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Abstract

The invention relates to a pH-responded micro-fluid self-driven micro-fluidic chip and a preparation method thereof. A micro-structure and a micro-channel are formed in the surface of the micro-fluidic chip; the surface of the micro-channel is modified through pH-responded molecules; under different pH stimulation, the change of the surface wettability of the surface is caused by the surface appearance of the micro-channel and the reversible change of the chemical configuration; the micro-fluid is controlled to move from bottom to top on the surface of the micro-channel so as to realize self-flowing of the micro-fluid; and the micro-fluidic chip is mainly applied to relevant fields of electrophoretic separation, chromatographic separation, immunoassay, reaction and the like. The micro-fluidic chip is simple to operate, realizes self-driving of the micro-fluid from bottom to top, greatly reduces the cost in driving the micro-fluid, has the characteristics of being portable, economic, rapid and efficient, and provides a completely new micro-fluid flowing control technique for driving-less flowing of the micro-fluid.

Description

technical field [0001] The invention relates to a pH-responsive microfluidic self-driven microfluidic chip and a preparation method thereof. The surface of the microfluidic chip has microstructures and microchannels, and the surface of the microchannels is modified by pH-responsive molecules. Under stimulation, the reversible changes in the surface morphology and chemical configuration of the microchannel lead to changes in surface wettability, controlling the movement of microfluids from bottom to top on the surface of microchannels, thereby realizing the spontaneous flow of microfluids, mainly used in electrophoresis Separation, chromatographic separation, immunoassay, reaction and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, convenience and speed, and has been widely used in many fields, such as cell biology, analytical chemistry, environme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 沙俊
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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