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Polydimethylsiloxane micro-fluidic chip and preparation method thereof

A technology of polydimethylsiloxane and polydimethylsiloxane materials, which is applied in the field of preparation of polydimethylsiloxane microfluidic chips, can solve the problem of poor bonding strength, easy leakage, Expensive and other issues, to achieve the effect of fast sealing and reversible bonding

Inactive Publication Date: 2013-04-24
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the reversible bonding mainly uses the certain adhesion and high flatness of the PDMS surface to directly bond two PDMS substrates, but its bonding strength is poor and it is easy to leak; the irreversible bonding mainly uses surface activation bonds. The bonding method is that the surfaces of the two PDMS substrates are treated with plasma activation or ultraviolet irradiation for a certain period of time and then bonded to achieve permanent sealing. Although the bonding strength of the chip obtained by this method is high, it requires expensive plasma. Generator or specialized ultraviolet irradiation equipment, and the processing process often takes about tens of minutes, which often becomes the main step that restricts the entire chip preparation process

Method used

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  • Polydimethylsiloxane micro-fluidic chip and preparation method thereof
  • Polydimethylsiloxane micro-fluidic chip and preparation method thereof
  • Polydimethylsiloxane micro-fluidic chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] figure 1 It is a schematic cross-sectional structure diagram of a polydimethylsiloxane microfluidic chip in Example 1 of the present invention.

[0025] exist figure 1 In the middle, the upper layer is a polydimethylsiloxane cover sheet layer, the middle layer is a double-sided adhesive layer, and the lower layer is a polydimethylsiloxane base layer. The microchannel of the microfluidic chip is directly processed on the double-sided adhesive material of the middle layer. The specific method is: using laser etching method on the commercialized A transparent microchannel pattern is processed on the Tape type double-sided adhesive tape. The cover sheet layer and the base sheet layer are mixed and degassed by polydimethylsiloxane prepolymer and initiator in a ratio of 10:1. Obtained by pouring on a sheet of flat glass. After punching out the inlet and outlet of the solution on the cover sheet layer, the upper and lower layers of polydimethylsiloxane substrates are align...

Embodiment 2

[0027] figure 2 It is a schematic cross-sectional structure diagram of a polydimethylsiloxane microfluidic chip according to Example 2 of the present invention.

[0028] exist figure 2 In the middle, the upper layer is a polydimethylsiloxane cover sheet layer, the middle layer is a double-sided adhesive layer, and the lower layer is a polydimethylsiloxane base layer. The microchannel of the microfluidic chip is directly processed on the upper layer of polydimethylsiloxane siloxane material. The specific method is: a silicon template with micro-protrusion patterns on the silicon substrate is prepared by traditional micro-processing methods, and the The polydimethylsiloxane prepolymer and the initiator are mixed at a ratio of 10:1, degassed, and cast on a silicon template to obtain a microchannel substrate with a microgroove structure. The polydimethylsiloxane-based sheet of the lower layer is directly obtained by mixing the polydimethylsiloxane prepolymer and the initiator ...

Embodiment 3

[0030] image 3 It is a schematic cross-sectional structure diagram of a polydimethylsiloxane microfluidic chip according to Example 2 of the present invention.

[0031] exist image 3 In the middle, the upper layer is a polydimethylsiloxane cover sheet layer, the middle layer is a double-sided adhesive layer, and the lower layer is a polydimethylsiloxane base layer. The microchannel of the microfluidic chip is directly processed on the underlying polydimethylsiloxane siloxane material. The specific method is: a silicon template with micro-protrusion patterns on the silicon substrate is prepared by traditional micro-processing methods, and the The polydimethylsiloxane prepolymer and the initiator are mixed at a ratio of 10:1, degassed, and cast on a silicon template to obtain a microchannel substrate with a microgroove structure. The polydimethylsiloxane-based sheet on the upper layer is directly obtained by mixing the polydimethylsiloxane prepolymer and the initiator in a r...

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Abstract

The invention relates to a polydimethylsiloxane micro-fluidic chip and a preparation method thereof. The polydimethylsiloxane micro-fluidic chip is characterized in that the polydimethylsiloxane micro-fluidic chip consists of three layers of base materials, wherein the upper layer is a polydimethylsiloxane cover layer, the middle layer is a double-sided rubber layer, and the lower layer is a polydimethylsiloxane basal layer; and the micro-fluidic chip is prepared by adhering the upper and lower layers of base materials and the middle layer. The preparation method is characterized by comprising the following steps in sequence: (1) designing and drawing micro-channels of the micro-fluidic chip by using computer-aided design software; (2) processing the micro-channels as well as sample inlets on the base materials of the chip through a micro-processing technology; and (3) aligning, pressing and sealing the three layers of base materials to prepare the micro-fluidic chip. The polydimethylsiloxane micro-fluidic chip and the preparation method thereof have the advantages that no generator or ultraviolet irradiation equipment needs to be used in the preparation of the polydimethylsiloxane micro-fluidic chip provided by the invention, and rapid sealing of the polydimethylsiloxane can be realized.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to a method for preparing a polydimethylsiloxane microfluidic chip. Background technique [0002] Microfluidic chips, also known as micro-total analysis systems, are a type of micro-reaction or analysis systems characterized by micro-channel networks. Due to the advantages of fast analysis speed, low reagent consumption, low cost of use, easy integration and automation, microfluidic chips have become a very active scientific frontier and have been widely used in research in chemistry, biology, medicine and other fields. . [0003] Chip fabrication technology is a major research focus of microfluidic systems. At present, the materials used to make microfluidic chips mainly include silicon, glass, and high molecular polymers, among which polydimethylsiloxane (polydimethylsiloxane, PDMS) belongs to an elastic high molecular polymer material. It has become one of the most commonly used material...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 叶嘉明
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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