Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for converting danshinolic acid B into tanshinol in shenxiong glucose injection preparation process

A technology for the preparation of injections and Shenxiong glucose, which is applied in the preparation of carboxylic acid esters/lactones, organic chemistry, etc., to achieve the effects of reducing the purification process, increasing the content, and reducing equipment investment

Active Publication Date: 2013-04-24
GUIZHOU JINGFENG INJECTION
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The technical problem to be solved by the present invention is to provide a method for the preparation of Shenxiong Injection in view of the problem that salvianolic acid B cannot be converted into Danshenin in the maximum amount in the process of extracting, purifying and refining Danshensu in the preparation process of Shenxiong Injection. An extraction method for converting salvianolic acid B into danshensu, which can convert salvianolic acid B into danshensu in the extraction process, the content of salvianolic acid B in the extract is very low, and the content of the target danshensu has been greatly increased improve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for converting danshinolic acid B into tanshinol in shenxiong glucose injection preparation process
  • Method for converting danshinolic acid B into tanshinol in shenxiong glucose injection preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take Danshen medicinal materials, after selection-removal of impurities-cutting, weigh 350Kg of net medicinal materials, put them into the extraction tank, add purified water 6 times the amount of medicinal materials, soak at a temperature of 40-50°C for 30 minutes After boiling, keep it warm for 60 minutes at a temperature of 97°C under normal pressure, filter, and pass through a 100-mesh sieve to obtain the first filtrate. Under pressure conditions, keep warm for 60 minutes, filter, and pass through a 100-mesh sieve to obtain the second filtrate; combine the two filtrates, concentrate under reduced pressure until the volume is less than 1 times the weight of the medicinal material. After 2 alcohol precipitations (the first alcohol content reaches 60%-75%, the second alcohol content reaches 80%-85%), 1 water precipitation, and concentration to a relative density of 1.28 to obtain the salvia miltiorrhiza extract.

[0024] This embodiment salvianolic acid B content and D...

Embodiment 2

[0028] Take Danshen medicinal materials, after selection-removal of impurities-cutting, weigh 350Kg of net medicinal materials, put them into the extraction tank, add purified water 6 times the amount of medicinal materials, soak at a temperature of 40-50°C for 30 minutes After boiling, keep it warm for 60 minutes at a temperature of 98°C under normal pressure, filter, and pass through a 100-mesh sieve to obtain the first filtrate. Under pressure conditions, keep warm for 60 minutes, filter, and pass through a 100-mesh sieve to obtain the second filtrate; combine the two filtrates, concentrate under reduced pressure until the volume is less than 1 times the weight of the medicinal material. After 2 alcohol precipitations (the first alcohol content reaches 60%-75%, the second alcohol content reaches 80%-85%), 1 water precipitation, and concentration to a relative density of 1.29 to obtain the salvia miltiorrhiza extract.

[0029] This embodiment salvianolic acid B content and D...

Embodiment 3

[0046] Take Danshen medicinal materials, after selection-removal of impurities-cutting, weigh 3Kg of net medicinal materials, put them into the extraction tank, add purified water 6 times the amount of medicinal materials, soak at a temperature of 40-50°C for 30 minutes , after boiling, keep the temperature at 114°C and the pressure at 0.075Mpa, keep the heat for 60 minutes, filter, and pass through a 100-mesh sieve to get the first filtrate. Keep warm at 111°C and pressure 0.08Mpa, keep the pressure for 60 minutes, filter, and pass through a 100-mesh sieve to obtain the second filtrate; combine the two filtrates, concentrate under reduced pressure until the volume is less than 1 times the weight of the medicinal material. After 2 alcohol precipitations (the first alcohol content reaches 60%-75%, the second alcohol content reaches 80%-85%), and 1 water precipitation, it is concentrated to a relative density of 1.29 to obtain the salvia miltiorrhiza extract.

[0047] This embod...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for converting danshinolic acid B into tanshinol in a shenxiong glucose injection preparation process. The method is characterized in that water is added to salviae miltiorrhizae medical materials to be boiled, after boiling, after heat preservation and pressure maintaining for 30-60 minutes under the condition that the temperature is 90 DEG C-150 DEG C and the pressure is 0.05 MPa-0.2 MPa, decoction is obtained after filtering, the decoction is concentrated to obtain salviae miltiorrhizae extract after alcohol precipitation and water precipitation through decompression concentration, and the content of the danshinolic acid B in the salviae miltiorrhizae extract is not detected. According to the method, the danshinolic acid B can be converted into the tanshinol to the maximun degree, the content of the danshinolic acid B in extractives is low, and the content of the target tanshinol is greatly improved. The method can convert the danshinolic acid B into the tanshinol in the extraction process, the content of the danshinolic acid B in the extractives is low, and the content of the target tanshinol is greatly improved. The target composition prepared by the method is the extract of the tanshinol, the purification treatment process in the purification process is reduced, and the content of the target tanshinol is greatly improved. Equipment investment is small, and the method is suitable for industrial mass production.

Description

Technical field: [0001] The invention relates to a preparation method of danshensu, in particular to a method for maximally converting salvianolic acid B in salvia miltiorrhiza into danshensu in the extraction process during the preparation of Shenxiong injection. Background technique: [0002] Chinese name: Danshensu (phenolic aromatic acid compound, brown or yellow), English name: Danshensu, alias: B-(3,4-dihydroxyphenyl) lactic acid, D(+)B-(3,4 -Dihydroxyphenyl) lactic acid Salvia A, chemical name: Propanoic acid, 3-(3,4-dihydroxyphenyl)-2-hydroxy-, molecular formula C9H10O5, molecular weight: 198.17. [0003] The structural formula is shown in formula (1): [0004] [0005] Chinese name: salvianolic acid B, English name: Lithospermic acid B, alias: salvianolic acid B, salvianolic acid B, salvianolic acid B, formed by condensation of 3 molecules of danshensu and 1 molecule of caffeic acid, with two Carboxyl group, molecular formula is C36H30O16, molecular weight: 718...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C59/52C07C51/09
Inventor 叶湘武余渊冯世明
Owner GUIZHOU JINGFENG INJECTION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com