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N-(2)-L-alanyl-L-glutamine compound

A technology of glutamine and alanyl, which is applied in the field of N(2)-L-alanyl-L-glutamine compounds, can solve problems such as glutamine deficiency, and achieve good performance, solubility and Excellent stability, simple and controllable preparation method

Active Publication Date: 2013-05-01
西安万隆制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, if sufficient glutamine is not supplemented, a relative deficiency of glutamine will occur

Method used

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  • N-(2)-L-alanyl-L-glutamine compound
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  • N-(2)-L-alanyl-L-glutamine compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] At 35°C, slowly add 4.0g of N(2)-L-alanyl-L-glutamine powder into 50ml of dioxane, stir to dissolve it, then stir the solution at this temperature for 14 hours, then cool down Crystals began to precipitate, and when the temperature was lowered to 5°C, a large amount of crystals precipitated, filtered, washed with propanol, dried, and 3.2 g of type III crystals were collected.

[0021] The powder X-ray diffraction pattern of the solid is shown in figure 1 shown. Powder X-ray diffraction was performed using the Scintag X2 Advanced Diffraction System (operated by ScintagDMS / NT 1.30a and Microsoft Windows NT 4.0 software). The system uses a Cu X-ray source (45kV and 40mA) to provide 1.5406 Cu Kα 1 ray, and a solid state Peltier cooled detector. The beam aperture was controlled using tube divergence and anti-scatter slits of 2 and 4 mm and detector anti-scatter and acceptance slits of 0.5 and 0.2 mm wide. Data were collected from 2 to 50° (2Θ) using a step scan with a ...

Embodiment 2

[0024] At 40°C, slowly add 5.0g of N(2)-L-alanyl-L-glutamine powder into 50ml of dimethylformamide, stir to dissolve it, and then stir the solution at this temperature for 12 After 1 hour, crystals began to precipitate when the temperature dropped to 8°C, a large amount of crystals precipitated, filtered, washed with propanol, dried, and 4.2 g of type III crystals were collected.

[0025] The powder X-ray diffraction pattern of the crystal is figure 1 resemblance.

Embodiment 3

[0027] At 50°C, slowly add 10.0g of N(2)-L-alanyl-L-glutamine powder into 100ml of dimethylformamide, stir to dissolve it, and then stir the solution at this temperature for 15 After 1 hour, crystals began to precipitate when the temperature dropped to 5° C., a large amount of crystals precipitated, filtered, washed with propanol, dried, and 8.3 g of type III crystals were collected.

[0028] The powder X-ray diffraction pattern of the crystal is figure 1 resemblance.

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Abstract

The invention provides an N-(2)-L-alanyl-L-glutamine (molecular formula: C8H15N3O4) III-type crystalline compound which has better solubleness and stability. Meanwhile, the invention also provides a preparation method for a new crystal including medicine composition and preparation agent thereof, particularly an injection.

Description

field of invention [0001] The present invention relates to N (2)-L-alanyl-L-glutamine (molecular formula is: C 8 h 15 N 3 o 4 )compound of. Background technique [0002] N(2)-L-alanyl-L-glutamine (molecular formula: C 8 h 15 N 3 o 4 ) is an ideal substance for intravenous glutamine supplementation, which can be quickly converted into glutamine and utilized in the body. N(2)-L-alanyl-L-glutamine can be decomposed into glutamine and alanine in the body, which makes it possible to supplement glutamine through parenteral nutrition infusion. The amino acids released by the decomposition of the dipeptide are stored in the corresponding parts of the body as nutrients and metabolized according to the needs of the body. [0003] In a severe stress state, the body's tissue cells increase their utilization and exceed the production capacity. Therefore, if sufficient glutamine is not supplemented, a relative deficiency of glutamine will occur. Parenteral nutrition enhanced wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/062A61K38/05A61P3/02
Inventor 王震杨朝福郑方晔李成利邓洪丽
Owner 西安万隆制药股份有限公司
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