Amino acid oligomer preparation method

Abstract

The invention relates to the organic polymer field, and concretely relates to an amino acid oligomer preparation method. The method comprises the following steps: dispersing amino acid in a solvent to prepare a solution having a concentration of 1-10M, cooling the solution to -10-5DEG C, slowly adding thionyl chloride having a mole 1-3 times higher than the mole of the amino acid in a dropwise manner, reacting for 0.5-6h, carrying out heating reflux of the solution for 2-6h, and removing the solvent to obtain an esterified amino acid salt; and dissolving the esterified amino acid salt in alcohol, adding a molecular weight adjustment agent having a mass being 0.1-20% of the mass of the amino acid salt, adding an alkali to adjust the pH value to 8-10, and reacting at a maintained reaction temperature of 25-50DEG C for 0.5-4h to obtain the acetic acid terminated amino acid oligomer having an average polymerization degree of 2-100. The method which omits the routine protection and deprotection process of the amino groups of the amino acid has the advantages of simple steps, simple synthetic conditions, and low cost, and can be used for the industrial production of the amino acid oligomer to obtain amino acid oligomers having different polymerization degrees.

Description

technical field [0001] The invention relates to the field of organic polymer materials, in particular to a method for preparing oligomeric amino acids. Background technique [0002] As we all know, oligomeric amino acids, or polypeptides, are low-molecular-weight polymers between amino acids and proteins, and are polymerized from amino acids. Oligoamino acids play an important role in many fields such as biology and medicine. Due to the presence of a large number of amide groups in the molecular chain, strong hydrogen bonds can be formed between the molecular chains, and oligomeric amino acids can be used to graft molecular chains or copolymerize the polymer to improve the performance of the polymer. The synthesis of oligomeric amino acids generally adopts two methods: liquid phase and solid phase. The liquid phase method mainly adopts two protecting groups of BOC and Z to protect the amino and carboxyl groups and gradually remove the protecting groups to synthesize oligo...

AI Technical Summary

Problems solved by technology

However, biotechnology processes are complex and require complex purification equipment

Images